Osteoarthritis (OA) is the most common form of arthritis, affecting over 525 million people around the world. Characterized by pain, swelling, and stiffness resulting from the degradation of cartilage that provides cushion and protection between our bones, OA is an inflammatory condition without a clear and effective treatment. OA most commonly affects the hands, knees,…
Human Mesenchymal Stem Cells (hMSCs) are the non-hematopoietic, multipotent stem cells with the capacity to differentiate into mesodermal lineages such as osteocytes, adipocytes, and chondrocytes as well ectodermal (neurocytes) and endodermal lineages (hepatocytes). Until recently, when the immunomodulation properties of MSCs were proven to be clinically relevant, the use of these stem cells was met…
Mesenchymal stem cells (MSCs) have been widely studied and increasingly recognized as a potential therapeutic with the ability to initiate and support tissue regeneration and remodeling. While over 1100 clinical trials have been conducted to assess the therapeutic benefits of MSCs, there continues to be widespread variation surrounding the potential treatment outcomes associated with these…
Patients suffering from uncommon conditions, such as transverse myelitis, often have limited treatment options, since these conditions lack the funding and the research needed to understand the disease and its causes. Here we will discuss stem cells for Transverse Myelitis. Regenerative medicine, also known as stem cell therapy, unlocks a new understanding of conditions and…
Research has shown neuroinflammation to have a significant role in the pathogenesis of Parkinson’s disease (PD). Much of this same research has also demonstrated mesenchymal stem cells (MSCs), and specifically, allogeneic bone marrow-derived MSCs, can be effectively used as an immunomodulatory therapy for the potential treatment of PD. The goal of Schiess et al.’s study…
Multiple system atrophy (MSA) is a rare, degenerative adult-onset neurological disorder that affects your body's involuntary functions, including blood pressure, breathing, bladder function, and motor control. MSA also demonstrates several symptoms similar to those accompanying Parkinson’s disease, including slow movement, stiff muscles, and loss of balance[1]. Considering the rapid and fatal progression of MSA, there…
Multiple sclerosis (MS) is a chronic inflammatory disease that attacks myelin, the protective sheath that covers nerves and causes progressive and serious communication issues between the brain, central nervous system, and the rest of the body[1]. Currently, it's estimated that over 2.3 million people worldwide, and over one million people in the US have a…
When you live with chronic pain, almost any treatment option that offers relief can be tempting. Undergoing surgery for joint pain is a serious decision. Surgery comes with many risks, including potentially long and painful recovery times, and there is no guarantee that surgical treatments will resolve your pain. Before deciding whether surgery is the…
Neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) occur when neuron populations begin to diminish. There is currently no cure for these types of diseases, though clinical trials to explore various treatment options are ongoing. In particular, regenerative medicine, also known as stem cell therapy, is being heavily…
According to the CDC, stroke continues to be a major cause of serious disability for adults. It is also estimated that nearly 800,000 people in the United States have a stroke each year[1]. While 80% of those experiencing a stroke survive for at least one year following the event, more than 70% will continue to…
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