Studies

Doctor discussing a brain scan with an adult patient

Literature Review: Mesenchymal Stem Cell Paracrine Signaling in Neuroinflammation

Reviewed Evidence Reviewed Study 1: Exosomes Derived From Bone Marrow Mesenchymal Stromal Cells Promote Remyelination and Reduce Neuroinflammation in the Demyelinating Central Nervous System Authors: Zhang J, Buller BA, Zhang ZG, et al. Publication & Date: Experimental Neurology. 2022;347:113895. DOI / Link: https://doi.org/10.1016/j.expneurol.2021.113895 | PubMed Reviewed Study 2: Intranasal Delivery of Mesenchymal Stem Cell-Derived Exosomes…

Umbilical Cord-Derived MSCs and Immune Thrombocytopenia: Exploring a New Approach to Immune Balance

Umbilical Cord-Derived MSCs and Immune Thrombocytopenia: Exploring a New Approach to Immune Balance

When the Immune System Targets Platelets Platelets may be tiny, but they play an essential role in helping the blood clot and preventing excessive bleeding. In people with immune thrombocytopenia, or ITP, the immune system mistakenly attacks and destroys platelets faster than the body can replace them. When platelet levels become very low, patients may…

Can Combining Umbilical Cord MSCs Make Regenerative Therapies More Consistent?

Can Combining Umbilical Cord MSCs Make Regenerative Therapies More Consistent?

Not All Stem Cells Behave Exactly the Same When we talk about umbilical cord-derived mesenchymal stromal cells, or UC-MSCs, it can be easy to think of them as one uniform type of cell. In reality, cells collected from different umbilical cords can behave differently in the laboratory. Some may grow faster, while others may be…

iPSC-Derived Corneal Cells: A New Way to Help Restore the Eye’s Surface

iPSC-Derived Corneal Cells: A New Way to Help Restore the Eye’s Surface

When the Eye Loses Its Ability to Repair Itself The cornea is the clear outer surface at the front of the eye, and it plays a major role in vision. To stay healthy, it relies on a steady supply of cells that help repair and renew its surface. When those regenerative cells are badly damaged,…

Biomedical illustration of neurological research involving mesenchymal stem cells

Mesenchymal Stem Cells and Neurological Disorders: Understanding Their Potential for Brain and Nerve Repair

Scientific Study Review Featured Article: Mesenchymal Stem Cells for Neurological Disorders Original article: Read the original study review on PubMed Central Neurological disorders such as stroke, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, and spinal cord injury can damage cells and connections within the brain and spinal cord. Because the central nervous system…

Umbilical Cord MSC Extracellular Vesicles: Exploring New Possibilities for Skin Regeneration

Umbilical Cord MSC Extracellular Vesicles: Exploring New Possibilities for Skin Regeneration

Tiny Messengers With Big Potential Healthy skin is constantly repairing, renewing, and adapting. Behind the scenes, skin cells communicate through biological signals that help coordinate many of these processes. One area gaining attention in regenerative medicine involves small extracellular vesicles, or sEVs. These tiny particles are released by cells and carry proteins and other biological…

Using a Patient’s Own Cells to Help Repair the Cornea

Using a Patient’s Own Cells to Help Repair the Cornea

Helping the Eye Repair Itself The clear surface at the front of the eye, called the cornea, plays a major role in healthy vision. To stay clear and smooth, it depends on special regenerative cells found around the outer edge of the cornea. When these cells become badly damaged, the eye can have trouble repairing…

iPSC-Derived Cells and Parkinson’s Disease: Exploring a New Path for Neural Regeneration

iPSC-Derived Cells and Parkinson’s Disease: Exploring a New Path for Neural Regeneration

Replacing What Parkinson’s Disease Takes Away Parkinson’s disease develops as dopamine-producing neurons in the brain are progressively lost. Because dopamine plays an important role in controlling movement, this loss can contribute to symptoms such as tremors, stiffness, and slowed movement. Medications can help replace or mimic dopamine activity, but researchers are also exploring an entirely…

Umbilical Cord-Derived MSCs and Immune Recovery: Exploring a New Supportive Approach

Umbilical Cord-Derived MSCs and Immune Recovery: Exploring a New Supportive Approach

Supporting the Immune System After Transplantation Graft-versus-host disease (GVHD) is a complication that can occur after a donor stem cell transplant. It develops when donated immune cells begin attacking the recipient’s tissues, creating inflammation that may affect areas such as the skin, liver, and digestive system. When the condition does not respond adequately to corticosteroids,…

Umbilical Cord-Derived MSCs and Cardiac Function: Exploring the Potential of Repeat Infusions

Umbilical Cord-Derived MSCs and Cardiac Function: Exploring the Potential of Repeat Infusions

Exploring a Multi-Dose Regenerative Approach Mesenchymal stem cells (MSCs) continue to be studied for their ability to release biological signals that may help support tissue repair, blood vessel health, and a balanced inflammatory response. While many clinical studies have investigated a single MSC treatment, researchers are also interested in whether multiple doses could provide more…

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