Intrathecal cell delivery has emerged as a promising approach for improving the quality of life for patients with neurological conditions, thanks to previous studies showing its safety and potential benefits.
As part of this review, Mesa Bedoya et al. summarize the findings of a systematic review and meta-analysis aimed at evaluating the safety of intrathecally delivered mesenchymal stem cells (MSCs).
Neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, significantly impact patients’ quality of life and contribute to a substantial global disease burden. With limited treatment options available, MSC therapy has gained attention due to its ability to differentiate into various cell types, secrete growth factors, and provide neuroprotection. MSCs can be delivered through several routes, including intrathecal administration, which allows for direct delivery to the central nervous system (CNS) and has been shown to enhance cell bioavailability near damaged areas.
The authors’ primary goal was to assess the safety of intrathecal MSC administration by analyzing randomized controlled trials (RCTs) comparing this method to control treatments in adult patients with neurological conditions.
As part of this review, Mesa Bedoya et al. conducted a thorough search of several databases up through April 2023, including RCTs that compared intrathecal MSC delivery with control treatments. They focused on adverse events (AEs) and performed a meta-analysis using statistical models to evaluate the overall safety. The authors also examined potential factors influencing the occurrence of AEs and assessed publication bias.
A total of 303 records were reviewed, with nine RCTs involving 540 patients meeting the inclusion criteria. The analysis revealed that intrathecal MSCs were associated with an increased probability of AEs related to musculoskeletal and connective tissue disorders. Specifically, fresh MSCs had a higher probability of causing AEs compared to cryopreserved MSCs. Additionally, multiple doses of MSCs were associated with a 36% reduction in the probability of AEs compared to single doses.
Despite these findings, the data did not show significant associations between AEs and various study covariates. The review highlighted that, while there was a higher incidence of musculoskeletal and connective tissue disorders, no serious adverse events (SAEs) were reported. The most common AEs, which included back pain, pain in extremities, and muscle aches, were generally transient and minimal in risk if patients were monitored appropriately.
Mesa Bedoya et al’s study supports the notion that intrathecal MSC delivery is a generally safe procedure, with an increased risk of specific, minor AEs. It also confirms previous findings that suggest this method is a viable option for delivering MSC therapy to patients with neurological conditions.
However, the authors also acknowledge limitations, including potential small-study effects and issues related to the crossover design of some included trials. These limitations suggest that the results should be interpreted with caution, and the findings highlight the need for larger, well-designed RCTs with longer follow-up periods to validate the safety and efficacy of intrathecal MSC delivery.
The authors conclude that this review indicates that intrathecal delivery of MSCs results in a minor increase in AEs related to musculoskeletal and connective tissue disorders but no serious adverse events. This supports the safety of intrathecal MSC therapy for neurological conditions, though further research with larger sample sizes and more rigorous study designs is needed to confirm these findings and address the limitations identified.
Source: Mesa Bedoya, L.E., Camacho Barbosa, J.C., López Quiceno, L. et al. The safety profile of mesenchymal stem cell therapy administered through intrathecal injections for treating neurological disorders: a systematic review and meta-analysis of randomised controlled trials. Stem Cell Res Ther 15, 146 (2024). https://doi.org/10.1186/s13287-024-03748-7
Multiple sclerosis (MS) is a long-term inflammatory disease that affects the central nervous system (CNS) of an estimated 3 million people worldwide. Characterized by the loss of the protective covering (myelin) of nerve fibers and degeneration of the nerve fibers themselves, MS damage disrupts communication between the brain and the rest of the body. Most MS patients start with a form known as relapsing-remitting MS (RRMS), where symptoms flare up at intervals and then partially or fully improve. Typical symptoms during these flare-ups include lack of muscle control, fatigue, and sensory impairments.
As the disease progresses, many individuals transition from RRMS to a progressive form of MS. Progressive MS is marked by a steady decline in function and an accumulation of disabilities, rather than periodic attacks. Unfortunately, the treatment options for progressive MS (PMS) are limited and often ineffective. The few available medications can help with active forms of PMS but are generally poor at slowing down the disease’s progression or promoting repair of damaged tissues.
The Promise of Stem Cell Therapy
Stem cell therapy has emerged as a promising approach to addressing the needs of patients with PMS. Stem cells have the unique ability to develop into various types of cells and offer several potential benefits, including providing support to nerve cells, modulating the immune system, and even replacing damaged cells. These characteristics make stem cells an attractive option for treating the complex pathology of PMS.
Current State of Stem Cell Therapy Research
In this review, Smith et al. explore the current state of preclinical and clinical evidence supporting the use of stem cells in treating PMS and discuss prospective hurdles impeding their translation into revolutionary regenerative medicines.
According to the authors, preclinical studies suggest that stem cells might help by reducing inflammation and protecting nerve cells in the CNS. However, translating these findings into effective treatments for humans remains a challenge.
Existing disease-modifying therapies (DMTs) have improved the treatment of RRMS by targeting the immune system to prevent the attacks that cause demyelination and nerve damage. These therapies work well for RRMS because they address the inflammatory processes that drive the disease. Unfortunately, as patients transition to the progressive phase of MS, conventional DMTs become less effective. PMS is characterized by a different set of pathological processes, including persistent inflammation behind a closed blood-brain barrier and activation of microglia (the brain’s immune cells) rather than T and B cells.
Stem Cell Therapy’s Potential Benefits
According to Smith et al. stem cell therapy offers potential benefits in several ways, including
Neuroprotection: Stem cells can potentially protect nerve cells from damage and death, which is crucial in progressive forms of MS.
Immunomodulation: Stem cells might help modulate the immune system, reducing harmful inflammation that contributes to disease progression.
Cell Replacement: Stem cells have the potential to replace damaged cells and promote the repair of damaged tissues.
While these potential benefits are compelling, the authors have found that the effectiveness of stem cell therapy in PMS is still largely unproven in clinical settings. The majority of current stem cell research focuses on the relapsing forms of MS or other diseases, with fewer studies dedicated specifically to PMS.
Current Status and Future Prospects
Stem cell therapy has demonstrated safety and feasibility across different types of cells and administration methods. The most promising results so far have been in studies involving neural stem cells (NSCs), which have shown potential in preclinical models for reducing chronic neuroinflammation. However, substantial clinical research is needed to validate these findings and determine the practical benefits of stem cell therapy for PMS.
The authors conclude that while stem cell therapy holds considerable promise for treating progressive multiple sclerosis, more research is needed. Future studies should focus on large, well-designed clinical trials to assess the benefits and risks of stem cell treatments. If proven effective, Smith et al. believe that stem cell therapy could become a revolutionary treatment for PMS and offer hope to millions of patients affected by this debilitating condition.
Source: Smith JA, Nicaise AM, Ionescu RB, Hamel R, Peruzzotti-Jametti L, Pluchino S. Stem Cell Therapies for Progressive Multiple Sclerosis. Front Cell Dev Biol. 2021;9:696434. Published 2021 Jul 9. doi:10.3389/fcell.2021.696434
Liver cirrhosis (LC) is a severe global health problem, contributing to an estimated two million deaths annually. LC results from chronic liver diseases such as hepatitis B and C, alcohol consumption, non-alcoholic fatty liver disease, and autoimmune liver disease. When these diseases progress unchecked, they lead to liver cirrhosis, characterized by inflammation and fibrosis. Most patients with LC die from complications due to a lack of effective treatments and poor patient compliance. While liver transplantation is effective, it is costly and comes with risks like immune rejection and recurrent infections. This has led to an urgent need for alternative treatments for LC.
Mesenchymal stem cells (MSCs) offer a promising alternative due to their ability to renew themselves and differentiate into various cell types. MSCs have gained attention for their potential to treat tissue-damaging diseases due to their low immunogenicity and ability to home to injury sites. Animal studies have shown MSCs to be safe and effective in treating LC, and clinical trials indicate improvements in liver function with no significant adverse effects.
Lu et al.’s study aims to systematically evaluate the efficacy and safety of MSCs for treating liver cirrhosis through a meta-analysis of clinical trials.
As part of this study, the authors analyzed data from PubMed/Medline, Web of Science, EMBASE, and Cochrane Library up through May 2023. Researchers used the PICOS principle for literature screening and assessed the risk of bias. Data from each study’s outcome indicators, such as liver function and adverse events, were then extracted and analyzed using Review Manager 5.4.
Eleven clinical trials met the criteria for this analysis. The pooled data showed significant improvements in primary and secondary liver function indicators. Patients who received MSC infusions had higher albumin (ALB) levels at 2 weeks, 1 month, 3 months, and 6 months, and lower MELD scores at 1 month, 2 months, and 6 months compared to the control group. Hepatic arterial injections were particularly effective in improving these scores. Importantly, none of the studies reported severe adverse effects, indicating the safety of MSC therapy.
Key Findings and Recommendations
Considering the findings of this study, the authors provide a number of key findings and recommendations, including:
Duration of MSC Therapy: The study found that prolonging MSC treatment enhances its effectiveness in end-stage liver disease, improving symptoms such as appetite loss, mental depression, and jaundice.
Types of MSCs: MSCs can be derived from various tissues, and their effectiveness may vary. Most studies evaluated used bone marrow-derived MSCs (BM-MSCs), which have shown superior therapeutic effects compared to umbilical cord-derived MSCs (UC-MSCs). However, more research is needed to determine the best type of MSC for treating LC.
Routes of Administration: Different transplantation methods can impact the efficacy of MSC therapy. The hepatic artery route was found to be the most effective, likely due to better MSC homing to the liver. However, this method has clinical limitations such as high surgical risk. Intravenous administration, while safer, was less effective. The authors call for further research to optimize the administration route.
Secondary Indicators: While primary indicators like MELD score and ALB levels showed significant improvements, secondary indicators such as ALT, AST, TBIL, and INR did not show significant differences between the MSC and control groups. The authors believe this could be due to variability in disease cause, patient population, and follow-up duration.
Complications and Prognosis: MSC therapy also showed potential in reducing LC complications, such as portal hypertension and ascites, and decreasing mortality and hepatocellular carcinoma (HCC) incidence. However, more clinical trials are needed to confirm these findings and assess the long-term prognosis of MSC therapy in LC.
Lu et al. conclude that mesenchymal stem cell therapy is a safe and effective treatment for liver cirrhosis, significantly improving liver function without severe adverse effects. However, to fully realize the potential of MSC therapy, a standardized treatment protocol is needed. This includes optimizing the timing, dosage, frequency, and administration route of MSC infusions.
Additionally, MSC-derived exosomes show promise as an alternative treatment strategy. The authors call for further research, including multicenter, large-scale, long-term RCTs, to address these questions and improve the therapeutic outcomes for LC patients.
Amyotrophic Lateral Sclerosis (ALS) is a degenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle paralysis and death, typically within 3-5 years of onset. Despite two FDA-approved therapies, Riluzole, and Edravarone, which offer limited benefits, there remains no cure for ALS.
Considering this, researchers have turned to Mesenchymal Stem Cells (MSCs), which have shown promise in animal models and preliminary human trials for neurodegenerative diseases, including ALS.
Understanding ALS and MSC Therapy
ALS is characterized by the rapid degeneration of motor neurons, leading to muscle paralysis. The exact cause of ALS is complex and not fully understood. About 10% of cases are familial, while 90% are sporadic. Existing treatments only modestly slow disease progression and extend survival by a few months.
Stem cells, particularly MSCs, have shown potential in neuroprotection and immunomodulation. MSCs can be derived from various sources, including bone marrow, adipose tissue, embryonic tissue, cord blood, reprogrammed mature cells, and perinatal tissue. They support hematopoiesis and produce mesodermal cells. MSCs have demonstrated immunomodulatory and neurotrophic effects in animal models and early human trials.
As part of this study, Petrou et al. aimed to evaluate the safety and efficacy of repeated spinal injections of autologous MSCs in ALS patients. This open-label clinical trial included patients aged 20-70, with definite ALS diagnoses and ALS Functional Rating Scale Revised (ALSFRS-R) scores above 20. The patients received 1-4 intrathecal MSC injections at intervals of 3-6 months, with safety and tolerability as primary endpoints, and efficacy as secondary endpoints.
This trial found no serious adverse events, demonstrating the safety of repeated MSC injections. As evidence, the authors point out that, 15 out of 19 patients showed a reduction in the progression rate of their ALSFRS-R scores by more than 25% between the first and second injections, with an average improvement of 107.1%. Similar improvements were observed between subsequent injections. Thirteen patients experienced a 25% improvement in their progression rate over the entire treatment period, with an average improvement of 47.4%. Seven patients showed clinical improvement after the first transplantation, and five remained improved after the second cycle. These benefits were correlated with the intervals between the injections, suggesting that regular MSC administrations might be crucial for sustained efficacy.
Previous Studies on MSCs in ALS
Several small, open-label clinical trials have suggested that MSC treatment can be beneficial for neurological diseases, including ALS. In a phase I/II trial by the same research group, ALS patients received intrathecal and intravenous MSC injections, which were safe and showed a trend toward disease stabilization over six months. Another phase I/II and IIa trial with Brainstorm® used modified MSCs producing neurotrophic factors (MSC-NTF), showing at least a 25% improvement in disease progression, particularly in the intrathecally treated group.
Additional trials, including a randomized, placebo-controlled phase II study, demonstrated mixed results. While some trials noted improvements in a subgroup of rapid progressors, others did not show significant differences between MSC-treated and placebo groups overall. These studies highlight the need for repeated injections to maintain the benefits of MSC therapy.
Implications From the Current Study
According to Petrou et al., repeated intrathecal injections of MSCs over a longer follow-up period appears to induce significant, but short-term, clinical improvements and slow disease progression in a majority of patients. This study also reaffirmed the safety profile of MSC, with only mild and transient adverse events observed.
The study highlights the potential of MSC therapy in providing neuroprotection and slowing ALS progression. The immunomodulatory effects of MSCs, possibly reducing inflammation in the central nervous system, may also contribute to their therapeutic benefits. However, the small sample size and open-label design are limitations, necessitating larger, controlled trials to confirm these findings.
Future Directions
Petrou et al. concluded that repeated intrathecal injections of autologous MSCs are safe for ALS patients and suggest potential medium-term clinical benefits. However, larger studies are needed to confirm these findings. The consistent observation of safety and indications of efficacy across multiple cycles of treatment is encouraging, indicating that MSC therapy could slow the progression of ALS and improve patients’ quality of life.
The study’s promising results support the continued exploration of MSC therapy for ALS. The authors call for future trials to focus on optimizing the timing and frequency of MSC injections to maximize clinical benefits. Larger, controlled studies are essential to validate these findings and potentially establish MSC therapy as a viable treatment option for ALS. By addressing the unmet needs in neuroprotection and immunomodulation, MSC therapy holds the potential of improving the quality of life and survival for ALS patients.
Source: Panayiota Petrou, Ibrahim Kassis, Nour Eddine Yaghmour, Ariel Ginzberg, Dimitrios Karussis. A phase II clinical trial with repeated intrathecal injections of autologous mesenchymal stem cells in patients with amyotrophic lateral sclerosis. Front. Biosci. (Landmark Ed)2021, 26(10), 693–706. https://doi.org/10.52586/4980
“Back pain” is a general term that can mean many different things. From nerve pain to strained back muscles, there are various reasons your back might hurt. Dealing with chronic back pain is mentally and physically exhausting, and you deserve relief. The first step in properly managing your chronic back pain is to know what’s behind it. Use this guide to shed some light on the potential root cause of back pain, and available treatments for your comfort.
Why Does Your Back Hurt?
If you’ve experienced severe back pain before, your first question is probably, “Why?” It might feel like you’re willing to do anything to stop the pain.
Unfortunately, there isn’t one universal cause for severe back pain. If you’re struggling with it, it’s time to examine what might be causing it.
Some of the circumstances that can cause chronic back pain include:
These are just a few of the debilitating problems you may be dealing with. A qualified healthcare professional can guide you to the proper diagnosis.
Muscular Back Pain
Your back is full of muscles that help you sit, stand, and move around. When one of these muscles’ experiences overuse, stress, or strain, you’ll feel it in major ways.
Movement Injuries
If you twist, sleep, or lift something in the wrong manner, you could end up with a strained back muscle. This will feel different than regular soreness after a back workout.
Sports injuries can affect your back muscles. Especially in contact sports and other intense activities, your back faces many risks each time you play. The more conditioned and flexible you are, the less likely you are to get an overuse or muscle strain injury.
Stress
Psychological stress can also lead to muscular back pain. When you’re stressed, your body tenses up in ways you may not even notice. The muscles in your back may become stiff, strained, or generally uncomfortable as a result.
Lack of Sleep
You also tend to lose sleep when you’re undergoing lots of mental stress. Your body uses sleep as the primary time to repair your muscles and make them stronger. If you aren’t getting enough rest at night or you work the third shift, your back muscles are more prone to pain and injury.
Neurological Back Problems
Your nervous system sends messages to all parts of your body using electrical impulses. The central hub for all of the nerves that extend outward from your body is your spinal cord. Neurological diseases and spinal cord injuries can impair your back in surprising ways.
Neuropathic Pain
Neuropathy develops when nerves throughout your body become damaged in some way. This is a common symptom of neurodegenerative diseases like MS. When your peripheral nerves are damaged, they can’t communicate with your brain properly, leading to strange sensations and pain.
Neuropathic back pain may feel like numbness, tingling, burning, “pins and needles,” or sharp excruciating pains. If you suffer from a neurological health condition, there’s a solid chance your back pain is related.
Car Accidents and Spine Injuries
Automobile accidents exert a lot of force and impact on your body all at once. When you get into an accident, even if it’s minor, your back and neck muscles can experience whiplash. In extreme cases, car accidents can also cause spinal injuries.
Spinal cord injuries are very serious. Your spinal cord protects your nerves and secures their pathway to your brain. Chronic back pain, numbness, and loss of limb function could indicate an underlying spinal injury.
Herniated Discs and Pinched Nerves
If one of the cartilage discs between your vertebrae becomes dislodged, it can press on the nerves surrounding it. A herniated disc can spell trouble for your mobility, limb functions, and comfort for years.
Vertebral problems can also pinch the nerves in your back, which results in the same thing — long-lasting sharp back pain. Discomfort from a pinched nerve will likely feel sudden, sharp, and breathtaking.
Lifestyle Factors and Back Pain
Certain aspects of your lifestyle may be causing your chronic back pain and soreness. These factors aren’t considered diseases themselves, but they can lead to chronic health problems that become long-term conditions.
The following are risk factors for chronic back pain:
Obesity
Poor posture
Sedentary lifestyle
Overtraining
Poor nutrition
Labor-intensive jobs
Improper lifting techniques
Whenever possible, you should avoid these risks. Steps like wearing a posture corrector and lifting heavy objects with your leg muscles can help prevent chronic back problems.
Solving Your Pain: Back Treatment Options
You don’t have to live in unbearable pain forever. You have options when it comes to severe back pain treatment. Every person has a different threshold for pain, and you may prefer less invasive, more natural treatments than someone else.
Medication
Pain medication will block your brain from receiving pain signals in your back. Medication is a valid option for people struggling to function due to chronic back problems. However, most medications don’t treat the root cause of your back pain. It’s a good idea to consider other treatments along with medication.
Surgery
Back surgery is intense, invasive, and risky, but for some people, it’s the best and only option. Severe spinal cord injuries and disc herniations may require immediate surgery to correct the problem. After surgery, you’ll likely be instructed to perform back exercises to improve your mobility.
Regenerative Medicine
Regenerative medicine, also known as stem cell therapy, for back pain may offer an innovative and cutting-edge option. By utilizing human-derived stem cells to repair and renew damaged tissues throughout your body, these “blank” cells can form into almost any type of specialized cell, making them a potential effective modality to help manage and heal chronic back pain.
Evaluating Your Options
It may take a few different interventions before you experience back pain relief. What’s important is that you don’t give up. With the proper treatment, you can experience mild to intense relief and continue on with your life. Medicine is always improving, and you have more options than ever before.
Your hair can be part of your identity. For some people, their hair is a symbol of their spiritual beliefs. Whether you’re focused on beauty and aesthetics or a deeper meaning behind your hair, hair loss can be devastating.
For some people, regenerative medicine is an innovative, research-based solution to hair loss. Learn more about how regenerative hair loss treatments may restore your healthy locks.
How Hair Loss Is Related to Your Well-Being
Losing hair is often a symptom of an underlying health problem. While some people experience hair loss due to genetics or lifestyle choices, others may face lurking medical issues. Here are some of the ways your hair growth (or lack thereof) is related to your physical and mental wellness.
Self-Esteem and Confidence
You may feel embarrassed, ashamed, or self-conscious if you start to lose your hair. Both men and women struggle with remaining confident after significant hair loss. Your mental well-being may suffer if you can’t get your hair to grow back on its own.
Some cultures associate losing hair with aging and other stereotypes. This can be devastating for someone going through medical, hormonal, or age-related hair loss. Healthy hair regrowth may help you regain the confidence you lost.
Hormones
Your hormones are chemical messengers that regulate all of your body’s processes. Hair growth is tied to your hormones, and any fluctuations or declines in certain hormones can lead to losing hair. Think about post-pregnancy hair shedding; this happens because your body’s cascade of pregnancy hormones changes.
Hormonal changes as you get older can affect your hair. Age-related hair loss and thinning primarily affect women due to declines in estrogen production, but this problem can affect men as well.
Genetic Baldness
Male-pattern baldness is passed down through families. If you carry the gene for this condition, you may experience very early balding, starting in your 20s or 30s. This can change your appearance and make you feel older than you really are.
There are no ill physical effects from male-pattern baldness besides losing hair. However, you may experience poor mental health as a result of your unwanted early hair loss and thinning.
There is no cure for male-pattern baldness, but you can take steps to treat it. Regenerative medicine is here to intervene and treat hair loss in a natural, science-based way.
ExogroPro: The Latest in Hair Regrowth Science
When you experience hair loss of any kind, you probably have two priorities — prevent further hair loss and replenish your missing hair. ExogroPro, a professional-grade hair loss solution, addresses both of these problems at once.
How It Works: Preventing Further Hair Loss and Regrowing Lost Hair
ExogroPro works to stimulate your hair follicles, causing them to grow healthy hair again. This treatment uses the power of specific exosomes, which carry materials between your cells.
ExogroPro is designed to send signals to your hair follicles that stimulate hair growth. Because of exosomes’ extracellular communication abilities, they may be able to revive “dead” hair follicles on your head.
Because of this treatment’s therapeutic effects on hair follicle health, it may help prevent further hair loss and thinning. By rejuvenating your hair follicles and preventing them from going dormant, ExogroPro offers a possible solution to unwanted lost hair.
The Procedure: What to Expect
The premium patent pending ExogroPro formula is injected into the scalp to deliver exosomes to the hair follicles. These exosomes originate from human stem cells, specifically mesenchymal stem cells. This is just another way we can harness the power of stem cells to regenerate and repair damaged tissues within your body.
After two to six months, you may notice your hair growing back thicker and fuller than before. The results window varies, but one thing is certain — hair regrowth is worth the wait.
The Benefits of Choosing Regenerative Medicine for Hair Growth
With many prescription hair growth drugs on the market, you may be wondering — why choose ExogroPro? Here are the major benefits of choosing regenerative medicine for hair regrowth and thickening.
May Be More Effective Than Traditional Treatments
There are numerous treatments for hair loss, including PRP injections, topical oils, and more. These have varying efficacy and likely won’t give you the results you’re looking for. Prescription-strength hair growth drugs may not work for you either, resulting in frustration and discouragement.
Regenerative medicine harnesses the power of science and innovation. By using human stem cells, we work with the body processes already in place within your system. Exosomes may prove to be more effective and efficient than other hair loss solutions.
Drug-Free Therapy
Exosomes are naturally found in the human body. When you choose ExogroPro, you choose drug-free natural therapy for your hair and scalp.
While prescriptions can be helpful for some people facing hair loss, it’s understandable to want a natural alternative. We work with your natural healing and regrowth processes, not against them.
Dual-Action Treatment: Prevention and Active Regrowth
It’s impressive to consider how ExogroPro not only prevents further lost hair but can revive faulty hair follicles. This dual mechanism is key to getting the full head of hair you’re after. If it works for you, you’ll no longer have to mourn the hair you’ve lost — you could potentially get it back!
Encourages Hair Health
Solving hair loss isn’t just about replacing lost hair. It’s also about growing healthy, strong locks that can withstand damage and remain intact. ExogroPro promotes hair follicle health by improving cellular communications in the injected tissues. What’s more promising than the idea of a full, healthy head of hair after hair loss and thinning?
Combating Hair Loss and Thinning with Medical Science
It’s important to seek evidence-based treatments for your hair loss. No matter what the root cause of your hair problems is, you may find regenerative medicine to be a viable solution.
You don’t have to mourn your lost hair forever. Regenerative medicine is at the forefront of medical innovation and science, which could spell good news for your hair.
This website and its contents are not intended to treat, cure, diagnose, or prevent any disease. Stemedix, Inc. shall not be held liable for the medical claims made by patient testimonials or videos. They are not to be viewed as a guarantee for each individual. The efficacy for some products presented have not been confirmed by the Food and Drug Administration (FDA).
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