Everything You Need to Know About ALS

by Stemedix | May 13, 2024 | ALS, Neurodegenerative Diseases, Regenerative Medicine, Stem Cell Research, Stem Cell Therapy

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Patients with this condition often experience a broad range of symptoms that get worse over time. While there’s no known cure, some interventions and regenerative therapies can be helpful.  

If you or a loved one has been diagnosed with ALS, it’s important to seek as much information as possible. That way, you can get the proper treatment and know what to expect as the disease manifests in your body. Here’s everything you need to know to be prepared for ALS. 

Lou Gehrig’s Disease: The Neurological and Muscular Effects 

ALS is also known as Lou Gehrig’s disease. Unfortunately, it has severe effects on your nervous system and muscular function as it progresses. 

Amyotrophic lateral sclerosis primarily affects your body’s motor neurons, which are responsible for dictating voluntary movements. Toward the end of the disease’s progression, involuntary movements like breathing can slow or stop entirely. 

When your motor neurons can no longer communicate with your muscles properly, your muscles start to waste away. This is called muscular atrophy. Once a muscle has atrophied, it no longer has enough tone to carry out normal movements. 

Since ALS is a progressive neurodegenerative disease, the symptoms get worse over time. In the later stages of the disease, ALS patients have trouble speaking, eating, swallowing, and making any voluntary movements at all. 

Who Gets ALS? Risk Factors and Genetic Components

Amyotrophic lateral sclerosis is usually a sporadic disease, meaning patients get it randomly without an obvious known cause. In some cases, although very rare, Amyotrophic lateral sclerosis is passed down through families. 

Genetic ALS stems from genetic mutations that are then passed on to children of affected parents. These cases only make up 10% or less of all ALS cases. 

Sporadic ALS may have certain risk factors, but there are no clear causes. This means scientists can’t yet point to a single cause of developing ALS if it’s not genetic. 

Possible Risk Factors for Sporadic Amyotrophic lateral sclerosis

Some loose associations between age, sex, and occupation have been made in relation to Amyotrophic lateral sclerosis cases. The presence of these risk factors does not guarantee that someone will develop ALS. 

These possible risk factors include: 

• Age: Being 55 to 75 years old 
• Sex: Early-life cases are most common in men 
• Military service: Veterans may be at higher risk 

One possible reason that military veterans are at higher risk for Amyotrophic lateral sclerosis is because of their exposure to toxins like pesticides. Being around harmful chemicals may contribute to the development of this debilitating disease, but scientists aren’t sure of this. 

The First Signs of ALS

There are two types of ALS onset — limb onset and bulbar onset. Limb-onset Amyotrophic lateral sclerosis affects your arms or legs or both at the same time. You may notice problems with coordination, fine motor control, walking, and using your hands.

Bulbar-onset ALS first affects the neurons that control your speech and swallowing abilities. You might notice difficulty getting your words out properly or trouble swallowing. 

It doesn’t take long for the beginning symptoms of ALS to spread and get worse. This is often how physicians diagnose ALS, as rapidly progressing symptoms usually indicate a serious neurological problem. 

Progressive Problems and More Serious Symptoms 

As ALS develops, symptoms can become severe and even debilitating. Some patients experience changes seemingly overnight, while others develop more serious symptoms over weeks or months. 

The neuron degeneration caused by ALS can start to interfere with essential body functions such as breathing, blinking, and swallowing. 

Respiratory Symptoms

Respiration problems are common in end-stage ALS. The muscles in your chest that support breathing may become weak or paralyzed entirely. 

Some respiratory symptoms of ALS include: 

• Shortness of breath (at rest) 
• Excess saliva
• Inability to clear your throat and lungs of mucus 
• Pneumonia
• Weak coughing 
• Worsened breathing when lying flat 
• Respiratory system failure 

Hospital interventions usually include ventilators to keep air flowing in and out of the patient’s lungs. 

Muscle Stiffness and Atrophy

As Amyotrophic lateral sclerosis interferes with their proper use, your muscles start to lose tone, mobility, and structure. This is known as muscle atrophy and may be accompanied by extreme stiffness. 

As Amyotrophic lateral sclerosis progresses, many patients lose the ability to speak loudly. The muscles involved in speech start to freeze up and become paralyzed. This can also cause an inability to swallow. 

Extreme Weight Loss

Being unable to consume food and fluids normally can lead to excessive weight loss in late-stage Amyotrophic lateral sclerosis patients. This isn’t a healthy type of weight loss, and it’s usually caused, in part, by loss of muscle mass. 

Mental Health Challenges 

Amyotrophic lateral sclerosis doesn’t affect your perception or cognition, meaning you can still hear, see, and think normally. Since the person is aware of their deteriorating condition, they may experience depression, anxiety, and other serious mental health challenges. Having a strong support system is key to remaining mentally well through your ALS journey. 

Treatment Options for ALS 

You can receive treatment for ALS to slow the progression of the disease. While there is no cure, medical intervention can help you maintain your quality of life for a longer period. 

ALS Medication

Some medications protect your motor neurons from further damage, which slows the progression of your ALS symptoms. These medications won’t revive damaged or dead neurons, but they can improve your disease prognosis. 

Physical and Occupational Therapy

Therapies that involve movement and motor functioning can help you maintain your muscle tone and avoid stiffness. While you still have the ability to move your limbs and smaller muscles, it’s crucial to practice doing so as much as possible. This repetition helps your brain and body stay in a good rhythm and slow motor damage. 

Regenerative Medicine

Some innovative treatments, like stem cell therapy for ALS, may improve your quality of life. Regenerative medicine focuses on healing and repairing damaged tissues and cells. 

Stem cell therapy uses unspecialized human cells to serve specific purposes throughout the body. In the case of ALS, stem cells are administered so they can differentiate into nerve cells to assist with your functioning and comfort. This may be worth considering if you want to approach your ALS symptoms from all possible angles. 

Living With Purpose: Life After an ALS Diagnosis

It’s important to maintain a positive outlook as much as possible. Having the support of medical professionals, family, and friends can make all the difference in your quality of life with Amyotrophic lateral sclerosis. Try not to lose hope; science is progressing toward new treatments every day.