What is Multiple Sclerosis Life Expectancy

What is Multiple Sclerosis Life Expectancy

Around the world, an estimated 1.8 million people live with multiple sclerosis. This autoimmune condition is chronic and can affect your life expectancy. The right treatment options, however, may impact the outcome you can expect. Learn about multiple sclerosis life expectancy and how the latest treatments help.

Understanding Multiple Sclerosis

Multiple sclerosis is a chronic autoimmune condition in which your immune system mistakenly attacks the sheaths that surround and protect the nerves in the spinal cord and brain, called the myelin. A damaged myelin interferes with the signals your brain sends to other parts of your body.

Symptoms of multiple sclerosis include:

  • Fatigue
  • Muscle weakness
  • Muscle spasms
  • Changes in gait
  • Loss of coordination or balance
  • Numbness or tingling in arms or legs

The causes of multiple sclerosis vary and are not always clear. They include being exposed to certain viruses or bacteria. People who had particular infections, like Epstein-Barr exposure, are more likely to develop MS. Other causes may be your environment, genetic mutations, and even how your immune system functions. 

Diagnosing Multiple Sclerosis

Getting an accurate diagnosis is one of the most crucial steps if you have multiple sclerosis. A definite test has not been developed for MS, but the symptoms you experience will lead your doctor to perform a physical exam, take blood, and get imaging tests like MRIs. 

MRIs can catch any lesions in your spinal cord or brain. These lesions develop as the disease damages the myelin. Your doctor may also perform a spinal tap. 

If these tests don’t offer a definite diagnosis, you may have to undergo an evoked potentials test. This test checks for nerve damage by measuring electrical activity in the spinal cord and brain. 

Multiple Sclerosis Life Expectancy: Factors to Consider

Newly diagnosed patients with MS who don’t have severe disabilities have a life expectancy of 30 years or more, but lots of factors play a role in determining this number. Your unique circumstances impact life expectancy. 

Disability Status

The Expanded Disability Status Scale (EDSS) is an important factor for healthcare providers attempting to provide an estimated life expectancy. The EDSS measures the level of disability in patients with MS. Everything from loss of independent ambulation to cognitive function is measured to provide the EDSS score. 

Mental Health

People with MS who experience mental health concerns like depression and anxiety may have a lower life expectancy. This is because mental health significantly impacts physical health and can even worsen the symptoms of MS. 

Compliance With Therapeutic Regimen

Following treatments as required impacts how the disease progresses, which then impacts your life expectancy. The type of treatment you receive is a factor. 

Lifestyle Changes to Improve Life Expectancy

For many people with MS, making some lifestyle changes helps impact their life expectancy. Diet is one of the changes. 

Following a healthy diet helps you manage symptoms while also improving your overall health. For MS patients, decreasing the intake of saturated fats and instead consuming  omega-3 polyunsaturated fatty acids helps prevent myelin loss in the central nervous system

Adding stress management techniques to your life is another change you can make. Stress makes MS symptoms worse. Trying breathing exercises, meditation, or turning to a therapist. These strategies can all improve your stress levels and impact your overall health. 

You also want to add physical exercise to your routine. Physical exercise may help slow down disease progression. Aerobic exercise may be able to decrease inflammation. It can also aid in decreasing depression and other mental health concerns that are a result of MS.  

Staying at a healthy weight is also vital for increasing life expectancy. People with MS have a higher risk of malnutrition, and they are more prone to being both underweight and overweight. Adding exercise to your day and improving your food choices will help you correct any nutritional issues you have, leading to better overall health. 

Getting better sleep is another important change you can make, as well as quitting any form of nicotine you may use. Smoking increases inflammation, which can make MS symptoms worse. 

How Regenerative Medicine Can Help

For people with MS, one promising treatment option is regenerative treatments like stem cell therapy. More people are turning to stem cell therapy because it may be able to decrease inflammation and improve symptoms with minimally invasive measures. 

Stem cell therapy uses stem cells, which are the cells that differentiate into the many types of cells in the body. For multiple sclerosis, mesenchymal stem cells are particularly useful because of their ability to repair myelin. They may also have a positive impact on the immune system. 

For this type of treatment, your healthcare provider removes stem cells from your bone marrow or fat, preparing them for an injection to reintroduce them into the body. Stem cell therapy is a great option for those searching for minimally invasive treatments that don’t require a long recovery process. 

Stem cell therapy gets right to the cause of MS symptoms: the damage of myelin. Unlike other treatment options, studies have shown that regenerative medicine has the potential to help with symptom management, slowing down progression, and provide a better quality of life. 

It is also a treatment option that may be less likely to cause side effects because the stem cells usually come from your body. 

Living With Multiple Sclerosis

Getting a diagnosis of multiple sclerosis can be stressful, but it’s crucial to know that many people with the condition live full and happy lives. Advances in medicine have made it easier than ever to extend your life expectancy with conditions like multiple sclerosis, especially if you receive an early diagnosis. 

Stem cell therapy and other forms of regenerative medicine work to offer you the help you need while targeting the cause of the disease. By combining stem cell therapy with lifestyle changes like exercising and eating better, you may be giving your body the ability to slow down the disease’s progression while improving your overall health. 

Tips to Keep Your Bones Healthy

Tips to Keep Your Bones Healthy

Your bones are essential for providing your body with support and stability, especially as you age. When you get older, you are more susceptible to conditions that can weaken bones and make them more prone to breakage.

Keeping your bones healthy throughout your life will strengthen them in old age and make you less likely to develop conditions like osteoporosis. Take a look at these tips for healthier bones.

Increase Calcium Intake

One of the best ways to strengthen your bones is to increase your calcium intake. Many people are deficient in calcium, and it puts them at a higher risk of osteoporosis and other conditions that weaken bones. You can increase your calcium intake by adding more whole milk, yogurt, and calcium supplements to your diet.

Stay Active

You don’t need to perform strenuous exercises or intense workouts. A daily walk, swimming, or even playing golf are all good ways to remain physically active.

People who lead a sedentary lifestyle tend to have weaker bones than those who get regular exercise. To strengthen your bones and reduce the risk of osteoporosis, you should strive to stay active throughout your whole life. 

Quit Smoking

Research has suggested that smoking cigarettes can increase your risk of bone breakage or developing osteoporosis. To help yourself maintain strong, healthy bones, it’s better to quit smoking as soon as possible.

Decrease Alcohol Consumption

In addition to tobacco products, alcohol can increase your risk of developing osteoporosis. For stronger, healthier bones, you should try to keep your drinking to a minimum.

Keep Hormones in Check

Some instances of weak bones and osteoporosis are linked to hormone imbalances. Getting your hormone levels regularly checked and ruling out thyroid conditions can help you keep strong bones for your entire life.

Heterogeneity of Mesenchymal Stem Cells in Cartilage Regeneration

Heterogeneity of Mesenchymal Stem Cells in Cartilage Regeneration

Articular cartilage, found on the surface of most musculoskeletal joints, distributes and transfers forces between bones and joints, provides a smooth surface for joint mobility, and plays an important role in human mobility. 

However, articular cartilage is also easily susceptible to damage, but difficult to repair itself on its own (primarily due to the fact it is mostly avascular). Over time, the inability of articular cartilage to repair itself leads to progressive joint pain, disfigurement, movement disorders, and ultimately osteoarthritis.

The CDC estimates that nearly 33 million Americans are currently affected by osteoarthritis, most often in the form of pain, stiffness, decreased mobility and range of motion, and swelling in the joints[1].

Current treatment methods, including microfracture technology, autologous or allogeneic cartilage transplantation, and autologous chondrocyte implantation (ACI) have demonstrated the ability to repair and regenerate fibrous cartilage, but not articular cartilage required for smooth, fluid, natural mobility.

To address this issue, recent research has focused on the efficacy of stem cells, and specifically mesenchymal stem cells (MSCs) found in bone marrow, adipose tissue, synovial membrane, and umbilical cord Wharton’s jelly, as potential therapeutic treatments for regeneration of articular cartilage. MSCs are particularly of interest due to their demonstrated abilities of self-renewal, multi-differentiation, and immunoregulation.

While the use of MSCs has demonstrated tremendous potential in the field of regenerative therapy, one notable drawback continues to be unstable or suboptimal results resulting from the heterogeneity of various mesenchymal stem cells.

Specifically, the stability and efficacy of MSCs appear to differ based on a number of factors, including the donor, the tissue source, and their ability for proliferation, differentiation, and immunoregulation.

For example, some of the key heterological differences highlighted in this review include the efficacy of MSCs based on donor’s age (with younger donors providing higher quality MSCs), Wharton’s Jelly MSCs showing greater prospects for application in cartilage regeneration than other MSCs, and differences within specific MSC subpopulations. 

The authors of this review acknowledge the potential of MSCs in repairing arterial cartilage, but also point out that there needs to be a deeper understanding of the heterogeneity of various MSCs in order to improve the efficiency of MSC-based therapies designed to repair arterial cartilage.  In addition, the authors also call for greater standardization in MSC isolation and harvesting methods among laboratories in order to provide better consistency with respect to results obtained from studies using MSCs.

Source:  “Heterogeneity of mesenchymal stem cells in cartilage regeneration.” 19 Mar. 2021, https://www.nature.com/articles/s41536-021-00122-6?elqTrackId=5517bd20493b470cb34fd0e8bc1f6ef9.


[1] “Osteoarthritis (OA) | Arthritis | CDC.” https://www.cdc.gov/arthritis/basics/osteoarthritis.htm.

Using Mesenchymal Stem Cells for Musculoskeletal Regeneration in Clinical Applications: Current Status and Perspectives

Using Mesenchymal Stem Cells for Musculoskeletal Regeneration in Clinical Applications: Current Status and Perspectives

Research exploring the benefits of mesenchymal stem cells (MSCs) has demonstrated tremendous potential as a regenerative therapy option for the musculoskeletal system. Research into these cell-based regenerative therapies is promising, and they must continue to provide the data necessary to show their therapeutic potential in clinical settings. 

In this review, Steinert et al. review and summarize some of the promising and unique therapeutic features of adult MSCs, detail their current state of clinical application as a regenerative musculoskeletal therapy, and describe the potential for future developments in this field.

Specifically, as a part of this review, the authors share the status of 31 clinical cell therapies for musculoskeletal regeneration occurring between 1996 through 2011 and specifically covering bone defects and nonunions, avascular necrosis of the hip, cysts and benign tumors of the bone, cartilage lesions, and tendons and ligaments; results for the majority demonstrate the safety of and/or the efficacy associated with the specific method of cell-delivery being evaluated.

The field of regenerative orthopedics points to the large body of MSC clinical research indicating the successful treatment of myocardial infarction, post-stroke or spinal cord injury nerve regeneration, graft versus host disease, and a variety of other conditions as an indication that the application has tremendous potential as a regenerative therapeutic option in a wide variety of musculoskeletal indications.

Although there appears to be evidence demonstrating the paracrine and trophic functions of MSCs, research explaining the specifically demonstrated therapeutic effects is still being determined. The authors highlight that research continues to explore the reasonable therapeutic expectations associated with MSC-based treatments, an essential step required to fully understand the range of healing associated with musculoskeletal regenerative cell-based therapy.

The authors, in concluding this review, point out that the demand for MSC-based musculoskeletal regenerative therapies continues to increase. Steinert et al. call for further study into the specific combination of cell preparation, bioactive factors, and stimuli for each specific MSC therapeutic application. Once these have been demonstrated for each application and should they demonstrate better or improved outcomes compared to standard treatments, only then can they be considered for long-term clinical application.

Source:  (n.d.). Concise review: the clinical application of mesenchymal stem cells …. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23197783/

Exploring the Role of Stem Cells in Spinal Surgery

Exploring the Role of Stem Cells in Spinal Surgery

Recent breakthroughs in the field of regenerative medicine continue to support the tremendous healing potential of stem cell therapy.  Until a few years ago, stem cell research was limited to only what could be gathered from the research gathered from embryonic stem cells; this research was limited by the well-documented ethical concerns surrounding the practice of harvesting stem cells from embryonic sources.

Fortunately, alternative – and less controversial – sources of stem cells, harvested primarily from autologous bone marrow and adipose tissue have demonstrated promise in treating many diseases ranging from autoimmune conditions to myocardial infarctions. 

Considering this, the ability of adult stem cells to undergo division and multipotent differentiation has garnered the attention of spinal surgeons and specialists around the world, specifically for the potential benefits of these stem cells in the treatment of a variety of spine issues related to neural damage, muscle trauma, disk degeneration as well as it potential in supporting bone and spine fusion.

Stem Cells in Spine Surgery

Although the rate of spinal surgery, and specifically lumbar, cervical and thoracolumbar fusions, has continued to rapidly increase over the last 20 year, there has not yet been a breakthrough in surgical technology that has consistently demonstrated the ability to reduce reoperation rates associated with these procedures; additionally, these procedures have demonstrated little success in reducing the issue of pseudoarthrosis in patients.

As a result, spinal surgeons have begun experimenting with using stem cells to support the process of bone growth and fusion. As stem cell research continued to evolve, the discoveries of the ability of mesenchymal stem cells (MSCs) harvested from bone marrow, adipose tissue, and skeletal muscle differentiate when cultivated in the correct microenvironment has led to the realization that these stem cells demonstrated a significant effect of the process of spinal fusion. 

Adding to the potential benefits of these stem cells are several animal model studies confirming the benefits of the much more available, and much easier harvested adipose-derived stem cell (ADSC).  In fact, several of these animal studies have confirmed similar fusion results observed when comparing MSCs and ADSCs.

Stem Cells in Disc Regeneration

Changes occurring in the discs of the spine and specifically starting in the second decade of life, contribute to decreased disc height that contributes to the impingement of nerves and the development of lower back pain consistent with Degenerative Disc Disease.

Until recently, treatment of Degenerative Disc Disease was limited to conservative management techniques, including work and lifestyle modifications, physical therapy, medication, and epidural injections, or surgery in the form of disc replacement or spinal fusion.

Although realizing the actual effects of stem cells therapy for treating this condition has been limited in humans (primarily due to concerns associated with the potential for an immune reaction to allogeneic stem cells in humans), several animal studies have demonstrated decreased disc degeneration as well as significant improvement in height and hydration of previously damaged discs.  In addition, small-scale studies in humans have demonstrated improvements in pain and disability within three months of stem cell treatment.

Considering this, Schroeder J et al. call for larger clinical trials designed to further explore the benefits associated with using stem cell therapy to treat Degenerative Disc Disease.

Stem Cells in Treatment of Spinal Cord Injury (SCI)

Spinal Cord Injury (SCI) resulting from damage to the spinal cord most often is the result of motor vehicle accidents, falls, or injuries occurring during sports, work, or in the home; currently, the World Health Organization (WHO) estimates that worldwide between 250,000 and 500,000 people suffer an SCI each year[1]

SCIs range in severity, but most often are accompanied by some degree of tissue damage and/or cell death.  As a result, spine surgeons have been exploring the potential of stem cell transplantation with the hope of supporting functional recovery after an SCI is sustained. 

There are several phases associated with SCI.  Regardless of the specific phase associated with an SCI, scientists have realized that creating a microenvironment that enhances neuron and axon regeneration appears to be the most desirable outcome of stem cell therapy.  It is hypothesized that this is best achieved by suppression of the inflammation that typically accompanies cell apoptosis and necrosis.

Although embryonic stem cells appear to provide greater differentiation than adult stem cells, the ethical concerns surrounding their use have limited further exploration of these potential benefits. However, to date, adult mesenchymal stem cells (MSCs) used in the treatment of SCI have not demonstrated immunologic reactions and have demonstrated the potential to promote axonal regeneration, suppress demyelination, induce nerve regeneration, and induce nerve regeneration.

Unfortunately, the in vivo differentiation of MSCs into neuron-like cells has been documented to be inefficient, meaning that MSCS is currently not capable of directly repopulating or physically restoring the tissue damaged in SCI. 

While there have since been studies exploring the transplantation of neural stem cells (NSC) that have demonstrated sensory and motor improvements after stem cell transplantation and when combined with other cell and growth factors, these improvements were not statistically significant. Considering this, the authors of this study indicate that it’s difficult to provide a definitive statement on the clinical potential of stem cell therapy for the treatment of SCI.

In conclusion, the authors point out that there are additional areas, including iatrogenic nerve and muscle injury resulting from spinal surgery, that have not yet been clinically addressed.  The authors also point out that greater standardization of in vitro experimentation and animal models may aid in the speed of translation of stem cell therapy in spinal surgery.

Source:  (n.d.). Stem cells for spine surgery – NCBI – NIH. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300930/


[1] “sheets/detail/spinal-cord-injury – WHO | World Health Organization.” 19 Nov. 2013, https://www.who.int/news-room/fact-sheets/detail/spinal-cord-injury.

PRP Therapy – Post Management Care

PRP Therapy – Post Management Care

Many studies support platelet-rich plasma (PRP) to help benefit patients with chronic pain and injuries. This article will cover the major aspects of post management care and the best tips to optimize results.

Important tips to keep in mind:

·   Avoid Taking any anti-inflammatory drugs after the procedure avoid for 14 days following the procedure

·   Apply heat only for 10-14 days , you may experience some soreness and swelling in this time period.

·   Avoid any strenuous activities, exercising and physical therapy for the week following treatment

·   Stay hydrated

·   Improvements typically begin after 2 weeks

About a week after the procedure, patients should start physical therapy, which involves myofascial release, gentle stretching, engaging the articular range of motion, and core stabilizing exercises.

Other activities (e.g., stationary bike, swimming) are also an appropriate choice during the recovery phase. Interventional imaging techniques such as stimulation therapy and Transcutaneous electrical nerve stimulation (TENS) should not be used at this stage.

Once 4-8 weeks have passed, patients can gradually engage in more intense activities, including yoga, Pilates, and light weight lifting. However, forceful rotation and manipulation are not recommended.

Following the correct guidelines during the first few weeks of recovery is crucial for the success of the procedure. The injected cells are quite delicate, hence the need to avoid strenuous physical activities that may cause irreversible damage to the cells.

Patients should also keep in mind that the side effect profile is diverse and can only be evaluated on a case-to-case basis. In other words, one patient might experience pain and inflammation after the procedure, while another presents with no symptoms.

The severity and extent of these symptoms are also dependent on the site of injection, with articulations being the most susceptible to traumatic injuries and side effects.

Recovery by weeks

Weeks 1 & 2

During this phase, you should restrict your movements and physical activity to avoid putting too much tension on your body. However, this doesn’t mean giving up to a sedentary lifestyle as it’s not the best approach.

Expect to experience pain, inflammation, and soreness.

Moreover, remember to avoid running, weight lifting, or any other strenuous exercise. Other activities, such as gentle stretching, are still allowed.

If you experience serious inflammation, consider using ice bags on the affected area , but try to avoid ice and NSAIDS until after the 14 day period. You can also use natural compounds that have potent anti-inflammatory properties, such as turmeric, CBD, and arnica.

Weeks 3 & 4

At this stage, the pain and inflammation should slightly subside, which allows you to practice more intense activities, but do not attempt to lift heavy weights or perform high-impact exercises. An appropriate number would be to keep the intensity of the workouts under 50% of what you’re used to. This will allow the stem cells to implant themselves in the damaged tissue and kick start the healing process.

Weeks 5 & 6

In this stage, focus on core-stabilizing exercises to strengthen your core muscles and give time for the joints to get used to the new routine. Activities such as stationary bike, elliptical, stretching, yoga, Pilates, and swimming exercise are permitted.

Weeks 7 & 8

Inflammation and pain might be gone at this time; however, you should still be careful about the type of exercises you’re performing. For patients who are still dealing with pain and swelling, you can use ice bags to accelerate the healing process.

Months 3–6

During this period, stem cells have reached their peak healing potential, which should not get interrupted with intense physical activity. Instead, settle down for less-strenuous workouts that do not involve any compressive, twisting, or pivoting movements. Avoid uneven ground. Contact a Care Coordinator today for a free assessment!

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