Stem Cell Research

Targeting Neuroinflammation and Glial Scar Formation in Spinal Cord Injury: The Emerging Role of Mesenchymal Stem Cells

Targeting Neuroinflammation and Glial Scar Formation in Spinal Cord Injury: The Emerging Role of Mesenchymal Stem Cells

Spinal cord injury (SCI) is a devastating neurological condition that disrupts communication between the brain and body. The injury unfolds in two major phases. The primary injury occurs at the moment of trauma, such as a fracture or dislocation of the vertebrae, which directly damages neurons and axons. This mechanical disruption can immediately sever nerve…

Stem Cell Therapies: A New Era in the Treatment of Multiple Sclerosis

Stem Cell Therapies: A New Era in the Treatment of Multiple Sclerosis

Multiple sclerosis (MS) is a long-term, immune-mediated disease in which the body’s immune system mistakenly attacks the central nervous system, including the brain, spinal cord, and optic nerves. Over time, this immune attack damages myelin—the protective insulation around nerve fibers—as well as the nerve fibers themselves. The resulting combination of inflammation, demyelination, and neurodegeneration disrupts…

Extracellular Vesicle Therapy for Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Potential

Extracellular Vesicle Therapy for Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Potential

Idiopathic pulmonary fibrosis (IPF) is a serious and chronic lung disease marked by progressive scarring of lung tissue. Over time, this scarring thickens and stiffens the lungs, making it increasingly difficult for oxygen to pass into the bloodstream. As lung function declines, patients may experience shortness of breath, persistent dry cough, fatigue, and reduced exercise…

Spinal Cord Injury and the Promise of Stem Cell Therapy

Spinal Cord Injury and the Promise of Regenerative Medicine

Spinal cord injury (SCI) is a life-changing condition that affects hundreds of thousands of people in the United States. Each year, approximately 17,000 new cases are reported, and more than 290,000 individuals are living with long-term effects. Damage to the spinal cord can lead to partial or complete loss of movement and sensation below the…

Understanding the Safety of Mesenchymal Stromal Cell Therapy

Mesenchymal stromal cell therapy, often called MSC therapy, has become one of the most widely studied approaches in regenerative and cellular medicine. Over the past two decades, researchers have explored its potential to treat a wide range of inflammatory and immune-related conditions, including heart disease, lung injury, autoimmune disorders, and complications following cancer treatment. As…

Mesenchymal Stromal Cell Therapy: Current Evidence, Challenges, and Future Directions

Mesenchymal stromal stem cells, commonly called MSCs, have been among the most-studied cell types in regenerative medicine over the past two decades. They have been tested in hundreds of clinical trials for conditions ranging from joint degeneration to heart disease, autoimmune disorders, lung injury, and complications after transplantation. MSCs have consistently been shown to be…

Mesenchymal Stem Cells for Autoimmune and Rheumatic Diseases: What the Research Shows

Autoimmune and rheumatic diseases affect millions of people worldwide and can involve the joints, skin, gut, nervous system, and many other organs. Conditions like rheumatoid arthritis, osteoarthritis, lupus, inflammatory bowel disease, multiple sclerosis, and Sjögren’s syndrome often cause chronic pain, fatigue, and progressive damage.  Standard treatments usually focus on calming the immune system with medications…

Mesenchymal Regenerative Medicine for Disc-Related Low Back Pain: Current Evidence

Low back pain is one of the most common health problems worldwide. It affects quality of life, limits work and daily activities, and creates a significant economic burden. In many adults, especially those over age 50, a key driver of this pain is lumbar intervertebral disc degeneration. When the disc between the vertebrae begins to…

Regenerative Pathways in Aging: The Role of Mesenchymal Stem Cells

Aging is a universal biological process marked by the gradual decline of physiological function across all organ systems. It is driven by a combination of genetic, environmental, and molecular factors that influence the rate of deterioration from birth onward. Although inevitable, scientific progress in regenerative medicine has identified potential ways to mitigate its effects and…

Mesenchymal Stromal Cell–Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Pulmonary Fibrosis

Pulmonary fibrosis is a chronic and progressive lung disease marked by abnormal scarring of the tissue surrounding the air sacs. This process thickens and stiffens the lungs, leading to shortness of breath, fatigue, and reduced oxygen exchange. Current medications, such as pirfenidone and nintedanib, can slow disease progression but do not reverse tissue damage. As…

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