Regenerative Medicine

Mesenchymal Stem Cells for Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes inflammation to affect many different body systems including the joints, skin, kidneys, blood cells, brain, heart, and lungs. Affecting over 5 million people worldwide, and associated with a wide range of symptoms, SLE is difficult to diagnose. Currently, there is no treatment to prevent or…

Advancements in COPD Treatment Options

Chronic obstructive pulmonary disease (COPD) is a condition that affects about 12.5 million people in the United States. COPD can become progressively worse over time and affect your breathing.  Although lifestyle changes, oxygen therapy, and medications have traditionally served as the standard treatment choices, there is now another promising option for treating COPD, regenerative medicine,…

Regenerative Medicine Using Mesenchymal Stem Cells

Biomedical applications of mesenchymal stem cells (MSCs) in the field of regenerative medicine continue to evolve. Coupled with the rapid development of molecular biology and transplantation techniques, MSC applications have become a central focus of research surrounding regenerative medicine.  Since being discovered nearly 50 years ago, the understanding of various techniques for MSC extractions and…

Regenerative Medicine Using Mesenchymal Stem Cells for the Treatment of Liver Disease

Liver disease accounts for nearly two million deaths annually and is responsible for 4% of all deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related deaths occur in men. Most forms of chronic liver disease result from viral infections, alcohol abuse, or metabolic disorders and eventually result in cirrhosis and liver…

A Review of Clinical Trials for Multiple Sclerosis with Mesenchymal Stem Cell Therapy

Multiple sclerosis (MS) is a progressive auto-immune disease that affects the central nervous system (CNS). Currently, it is estimated that nearly 2 million people worldwide are affected by MS.   Characterized by the body attacking the myelin (the protective sheath that covers the nerve fibers), MS causes communication issues between the brain and the rest of…

Exploring the Potential of Umbilical Cord as a Source for Mesenchymal Stem Cell-Based Therapy

Because of its ability to simultaneously activate multiple mechanisms, including paracrine, trophic, immunomodulatory, and differentiation, researchers consider mesenchymal stem cells to be an effective option for stem cell therapy.  After years of active research, bone marrow-derived MSCs (BM-MSCs) have been a prevalent source for MSC-based studies. There is also active research using MSCs from a…

Post Stroke Treatment and Diagnosis

What is Post Stroke and How is it Diagnosed? "Post-stroke" or "post-stroke period" refers to the period of time following a stroke. A stroke occurs when there is a sudden disruption of blood flow to a part of the brain, leading to brain cell damage and, potentially, the death of brain tissue. The severity and…

Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Role in Regenerative Medicine

Researchers continue to tout the potential of mesenchymal stem cells (MSCs) as an evolving approach for the repair of damaged tissue or lost cells.  Specifically, the ability of MSCs to differentiate and secrete beneficial factors and vesicles is believed to play the most influential role in the regeneration of injured tissues and cells affected by…

Symptoms of Kidney Disease

What is Kidney Disease? Kidney disease, also known as renal disease or nephropathy, refers to a condition in which the kidneys are damaged or unable to function properly. The kidneys play a crucial role in filtering waste products, excess fluid, and toxins from the blood, while also maintaining the body's electrolyte balance and producing important…

Adipose Tissue-Derived Mesenchymal Stem Cells and Their Contribution to Tissue Regeneration

Mesenchymal stem cells (MSCs) isolated from a wide variety of tissues and organs have demonstrated immunomodulatory, anti-inflammatory, and regenerative properties that contribute to a host of regenerative and immunomodulatory activities, including tissue homeostasis and tissue repair. The most frequently studied and reported sources of MSCs are those collected from bone marrow and adipose tissue.  In this…

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