Is ED a Warning Sign of Heart Disease?

Is ED a Warning Sign of Heart Disease?

Lots of symptoms and signs can warn you that you may be at risk of suffering from heart disease, but did you know erectile dysfunction is one of them? Learn more about the connection between cardiovascular issues and erectile dysfunction — and what treatment options you may have. 

Understanding How Erections Form

To understand how erectile dysfunction may be a sign of heart disease, it’s first necessary to know how an erection forms. 

Erections don’t just depend on the correct functioning of the genitals. Instead, the process relies on a complex set of interactions between your hormones, brain, blood vessels, and muscles throughout the body. 

The moment there’s a mental or physical stimulus, the process begins. When you’re aroused, your brain uses your blood vessels and nerves to send signals to the rest of your body. These signals stimulate blood to flow to the penis, letting the erectile chamber expand. 

Testosterone levels also play a role since it functions as a vasodilator, opening up your blood vessels. 

If there’s any kind of issue in any of these steps, it can result in erection problems. That also includes if your heart isn’t strong enough to pump blood or if there’s plaque buildup in your blood vessels. If either of those things happens, your erectile chamber won’t expand. 

Some of the most common signs of erectile dysfunction include:

  • Being able to get an erection but not maintain it long enough for intercourse.
  • Only sometimes being able to get an erection before intercourse.
  • Requiring a lot of stimulation to get or maintain an erection.
  • Complete inability to get an erection.

It can be normal to have trouble every once in a while, getting an erection, but if it starts occurring regularly, you should visit your doctor to understand what the problem is. 

Heart Disease and Erectile Dysfunction: Shared Risk Factors

Heart disease and erectile dysfunction share common risk factors, which is why, many times, one of these issues can point to another. 

Shared risk factors of these conditions include:

  • Age
  • Diabetes
  • High blood pressure
  • Non-active lifestyle
  • Smoking
  • High cholesterol
  • Obesity
  • Stress

If you have a family history of heart disease or erectile dysfunction, you are also more likely to develop the problem yourself because there are genetic factors at play. 

Is Erectile Dysfunction a Heart Disease Warning Sign?

Erectile dysfunction isn’t always a sign of heart disease, but it often is. This is because of the heart’s function in the process of forming an erection. 

If the arteries in the body are affected by atherosclerosis, which is when plaque builds and doesn’t allow as much blood to flow, this can lead to problems with blood flow to the penis. Atherosclerosis also increases your chances of having a heart attack. 

Because the arteries in the penis are so narrow, erectile dysfunction can be the first sign of plaque buildup. 

Another potential connection between erectile dysfunction and heart disease is endothelial dysfunction. This condition is when the blood vessels constrict instead of dilating, and it’s a type of non-obstructive coronary artery disease. Your arteries narrow even though there’s nothing blocking them. 

Treating Erectile Dysfunction

If you struggle with erectile dysfunction, your healthcare provider might suggest a number of treatment options depending on the underlying cause of the problem. 

If the problem is related to cardiovascular issues, including atherosclerosis, treatments can include lifestyle changes. This can mean becoming more active by adding cardiovascular exercises like walking, swimming, and jogging to your life. Always speak with your doctor before beginning any kind of exercise routine.  

Quitting smoking is another step you can take, as is adjusting your diet. You should limit your intake of saturated fats so that you can start lowering your cholesterol levels. 

You’ll want to avoid alcohol as well. Alcohol interferes with the messengers in the brain that tell the penis to fill with blood while also reducing the production of testosterone levels. Alcohol is also bad for your heart since it causes high blood pressure, putting more stress on the organ. 

Some oral medications that increase blood flow to the penis aren’t a good choice if you also have some types of heart disease, so it’s important to ensure that your doctor identifies what’s causing the erectile dysfunction before prescribing medications. 

An option that shows promising results is regenerative medicine. Regenerative medicine options like stem cell therapy provide the chance to treat the underlying cause of erectile dysfunction. 

Stem cell therapy relies on stem cells, which have the ability to transform into many other kinds of cells, encouraging the growth of healthier blood vessels so that the penis can receive better blood flow. 

One of the most important benefits stem cell therapies offers is that it doesn’t require an invasive procedure. 

Another regenerative medicine treatment option is platelet-rich plasma (PRP) therapy. PRP therapy uses a sample of your blood that contains concentrated platelet levels and is full of growth factors. 

A PRP injection stimulates blood flow and the growth of new and healthier blood vessels. 

Getting Help for Erectile Dysfunction

Erectile dysfunction can impact your whole life, affecting your self-esteem and even warning you that there may be other health issues to consider. Turning to your healthcare provider is the best thing you can do to understand what the underlying cause of the problem is and whether it points to issues like cardiovascular disease. 

For many men, dealing with erectile dysfunction, with or without heart disease issues, means making lifestyle changes and considering treatment options like regenerative medicine. 

Because choices like PRP therapy and stem cell therapy provide the chance to get to the root problem without putting you at risk of side effects, as medication does, it could be the right choice for men who are struggling with both erectile dysfunction and heart problems.  

6 Surprising Risk Factors for Erectile Dysfunction

6 Surprising Risk Factors for Erectile Dysfunction

In the United States, about 30 million men have some form of erectile dysfunction, according to research conducted by the National Institute of Diabetes and Digestive and Kidney Diseases. Erectile dysfunction can occur in men of any age, though it’s most common in those who are older. Despite this, it’s not a normal part of aging.  There are many causes of erectile dysfunction, from emotional to physical. However, most people are unaware of a few risk factors that could affect your chances of developing this condition. 

Understanding Erectile Dysfunction

Erectile dysfunction is a condition in which you are not able to get or maintain an erection firm enough for sexual intercourse. It can be a long-term or short-term problem. 

There are a few types of erectile dysfunction. One type is vascular erectile dysfunction, which results from issues with the blood vessels that send blood to the penis or the valves that hold blood. This is the most common form of erectile dysfunction. 

Neurogenic erectile dysfunction occurs as a result of nerve problems that stop signals from traveling from your brain to your penis. It can occur after trauma, radiation therapy, or conditions like spinal stenosis and multiple sclerosis. 

Hormonal erectile dysfunction occurs when you experience testosterone deficiencies, while psychogenic erectile dysfunction involves psychological causes. 

Surprising Risk Factors for Erectile Dysfunction 

Most men are aware that blood pressure issues, antidepressants, and even drinking alcohol can cause erectile dysfunction. Still, there are some surprising factors that can make your chances of dealing with this problem more likely. 

1. Sleep Apnea

Sleep apnea is a condition in which your breathing stops and restarts many times as you sleep. This irregularity leads to poor rest. Scientists have noticed that men who have sleep apnea have a higher risk of developing erectile dysfunction. 

The reason is not entirely clear, but it could be because the lack of sleep leads to dips in testosterone levels. Sleep apnea also restricts oxygen. Testosterone and oxygen are both crucial for maintaining healthy erections. 

Sleep apnea also leads to fatigue and potentially higher stress levels, all of which impact sexual function. Scientists have found that treating obstructive sleep apnea can also help erectile dysfunction symptoms. 

2. High Cholesterol

Having high blood cholesterol levels could also put you at a higher risk of developing erectile dysfunction. Perhaps the most common cause is the narrowing of blood vessels, also called atherosclerosis. High cholesterol levels can make this more likely to occur. 

Cholesterol is a fat-like substance in the blood that your cell membranes need and that helps produce certain hormones, bile acids, and vitamin D. At high levels, however, cholesterol builds up in artery walls and causes plaque, which narrows them. 

When that occurs, your penis doesn’t receive the amount of blood it needs to get and maintain an erection. 

3. Cycling

Although maintaining an active lifestyle tends to help with erectile dysfunction, cycling could be causing more harm than good. 

Hard bicycle seats often press on the perineum, which is the area between the scrotum and the anus, causing a compression of blood vessels. The compression makes it more difficult for the penis to get the needed blood flow. 

Scientists recommend using a softer seat or taking shorter rides to prevent the problem. Make sure to speak with your doctor about this if you suspect cycling could be causing erectile dysfunction issues. 

4. Canned Foods

Perhaps one of the most surprising risk factors of erectile dysfunction is the frequent eating of canned foods. Cans that hold food often contain the chemical bisphenol-A, also called BPA. BPA can affect your hormones, stimulating the production of female sex hormones and suppressing male sex hormones. 

5. Certain Medications

Lots of medications have the potential to affect sexual function, especially in men. This is because they can interfere with hormone pathways. 

One of these types of medications is selective serotonin reuptake inhibitors (SSRIs). These medications are antidepressants that function by increasing the levels of serotonin in the body, elevating your mood. The problem is that serotonin decreases sex drive. 

Blood pressure medications may also affect sexual function. Diuretics or ACE inhibitors decrease the blood flow that reaches the penis, making an erection more difficult to achieve. 

Other medications that could affect sexual function are those that treat Parkinson’s disease, antihistamines, and even non-steroidal anti-inflammatory disease. It is always a good idea to speak with your doctor about the side effects of any medications you take and to work with them to find alternatives. 

6. Leading a Sedentary Lifestyle

Another factor that can put you at risk of developing erectile dysfunction is leading a sedentary lifestyle. Being sedentary can cause decreased blood flow. Not leading an active life also makes it harder for your heart to function at its best. 

Even moderate exercise stimulates your body to produce nitric oxide, which is a short-lasting chemical that keeps your arteries open, including the ones that allow blood to flow into your penis. 

A sedentary lifestyle is associated with higher levels of fat in the body. The more fat you have, the more estrogen your body is likely to produce, which means your testosterone levels dip. It can also lead to a higher risk of developing diabetes, which impacts insulin resistance and makes the development of erectile dysfunction more likely.

Treating Erectile Dysfunction

Struggling with erectile dysfunction can affect your self-esteem, moods, and relationships. If you are dealing with this issue, it’s essential to reach out to your doctor for help. 

One option that offers the chance to get relief from erectile dysfunction is regenerative medicine. Regenerative medicine treatments like stem cell therapy focus on doing more than just treating the symptoms of the condition: they can help to treat the underlying problem that led to erectile dysfunction issues in the first place. 

If you are dealing with erectile dysfunction, consider asking your doctor about regenerative medicine. With these minimally invasive treatments, you could allow your body to start healing itself.

A Review of Regenerative Medicine for Erectile Dysfunction Using Stem Cells

A Review of Regenerative Medicine for Erectile Dysfunction Using Stem Cells

Erectile dysfunction (ED) is a disorder that affects the quality of life and the sexual relations of more than half of the male population aged over 40 years. Currently, it’s estimated that his disorder will affect more than 300 million men in the next five years.

According to the Mayo Clinic, male sexual arousal is a complex process that involves the brain, hormones, emotions, nerves, muscles, and blood vessels. Erectile dysfunction can result from a problem with any of these. Additionally, stress and mental health concerns can cause or worsen erectile dysfunction.

The treatment of ED has traditionally been based on the temporary enhancement of penile erection but without a permanent treatment option. Current temporary treatment options include phosphodiesterase type-5 inhibitors (PDE5is) such as vardenafil, avanafil, tadalafil, and sildenafil, which are the most widely known and used medications for the treatment of ED. 

Unfortunately, the treatment failure levels associated with these drugs are high, with unresponsive rates ranging between 20 and 40%. These failure rates often require the use of additional treatment options for the management of ED, including the use of intracorporeal injections, vacuum erection devices, and penile prosthesis implantation. However, the use and application is also limited due to the high cost, intolerance to side effects, pain, and unsatisfactory results. 

Recently, several studies have suggested the use of stem cells for the treatment of ED to be promising in terms of damaged tissue repair as well as clinical efficacy.

In their review of current literature, Protogerou et al. evaluate and summarize the methods of administration, the cell types used in the performed clinical trials, and the safety and efficiency of procedures designed to treat ED.

Specifically, the authors reviewed 10 clinical studies published between 2010 and 2020 and used bone marrow-derived stem cells (BMSCs), adipose tissue-derived stem cells (ADSCs), umbilical cord stem cells, and placenta-derived stem cells. One of the studies reviewed also examined the re-administration of stem cells as a potential therapeutic option. From the authors’ findings, each study demonstrated encouraging results characterized by improved sexual function with no side effects.

Protogerou et al. also point out a number of limitations with these studies, including each being a small study with a short follow-up period, various etiologies of ED, and without control groups.

Despite these limitations, the authors highlight the urgent need for a double-blind randomized controlled study for the clinical effect of stem cell treatment in ED to sufficiently understand the ideal therapeutic strategy for using stem cell therapy to treat ED. Source:  “Erectile Dysfunction Treatment Using Stem Cells: A Review – PMC.” 6 Jan. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825548/

Can Stem Cell Therapy Treat Erectile Dysfunction?

Can Stem Cell Therapy Treat Erectile Dysfunction?

Erectile dysfunction (ED) is characterized by difficulty getting or maintaining an erection firm enough for sexual intercourse. It affects up to 30 million men and can stem from a broad range of causes, including stress, limited blood flow to the penis, and underlying conditions such as high blood pressure. While addressing any existing health issues that could be contributing to ED is important, addressing ED itself is also critical to supporting sexual health and quality of life. You may be asking yourself can stem cell therapy treat erectile dysfunction?

Traditionally, treatments for ED have included PDE5 inhibitors such as Viagra. Yet, these drugs are among the most controversial on the market. They relax the blood vessel walls in certain areas of the body and, while typically effective in addressing ED, are linked to both minor and serious side effects. Common side effects include nasal congestion, vision impairment and light sensitivity, indigestion, and headaches. More serious side effects include painful and long-lasting erections, damage to the optic nerve, hearing loss, and heart attack, among others. 

When oral medications fail, treatments such as injection therapy and penile implants may be explored as a last resort. Yet, these treatments also have their own set of potentially serious side effects. For this reason, experts have been exploring alternative options for treating ED.

Stem Cell Therapy for Erectile Dysfunction 

One promising treatment for ED which has emerged recently is stem cell therapy. In one clinical trial, men who have experienced ED after prostatectomy for prostate cancer experienced improved erectile function, even after all previously attempted treatments showed no results. The treatment has also shown promise for improving erections in men whose ED is caused by underlying conditions such as diabetes.

Stem cells work to promote tissue regeneration and healing, due to their ability to either become new cells through self-renewal or give rise to virtually any other cell type in the body. No other cells have these remarkable capabilities. When administered strategically, they can, therefore, promote the repair of almost any type of damaged or injured tissue. 

Researchers are encouraged by their findings and believe that the treatment offers a powerful alternative to traditional therapies for ED, as well as a viable solution for patients who have not responded to other treatments. Men experiencing the frustrations of ED may therefore once again be able to achieve and maintain spontaneous erections without invasive surgeries, injections, or medications, thereby improving their sexual satisfaction and relationships. 

Natural Solutions for Erectile Dysfunction

Natural Solutions for Erectile Dysfunction

Erectile dysfunction (ED) may seem like an issue that exclusively affects sexual health, but it could actually be a telling indicator of larger issues with overall wellness. The issue could simply be a result of a lifestyle change, such as a new medication. For the majority of men, however, the underlying cause of ED is related to a physical issue, such as high cholesterol, clogged arteries, or high blood pressure.

The remedy for ED could, therefore, lie in making changes to promote better overall health. Here are some natural tactics you could try to improve both your wellness and your sex life:

Be Mindful of Heart Health

Your blood sugar, blood pressure, and cholesterol levels all influence the arteries in the heart, brain, and penis. It’s therefore essential to both your sexual and overall health that you monitor and control these levels. Meet with your doctor regularly to discuss your vascular health, and if needed, pursue lifestyle changes and medications to get on track. 

Maintain a Healthy Weight

Obesity is a known cause of ED, so losing weight if needed and maintaining a healthy body mass index (BMI) are some ways to combat the issue. Being overweight also contributes to diabetes and vascular disease risk, which are also causes of ED. Moreover, excess fat can alter hormone levels, which can play a role in the condition. Set a goal to reach and maintain a healthy weight to prevent or alleviate ED.

Exercise Regularly

Men who exercise regularly are 20-30% less likely to develop ED than their sedentary peers, according to a Harvard Health study. While participants in the study either ran or completed vigorous outdoor work, moderate and low-impact workouts can be beneficial, too. In fact, walking just 30 minutes a day is linked to a 41% drop in ED risk – proof that you don’t need to become a marathoner to enjoy the health benefits of physical activity.

Eat a Balanced Diet

Diet influences many aspects of health, and sexual wellness is no exception. According to the Massachusetts Male Aging Study, men who follow a diet rich in natural foods including vegetables, whole grains, and fish were less likely to experience ED than their peers. Limiting or avoiding refined grains and red or processed meats is also beneficial, according to the study.

Strengthen the Pelvic Floor

If you think Kegels are just for women, think again. Pelvic floor strength is important for both men and women. Men, in particular, need strength in this area to maintain rigid erections and prevent blood from leaving the penis. One study in the UK even showed that doing Kegels twice a day for three months, combined with healthy habits like weight loss and smoking cessation, showed better results than lifestyle changes alone.   

Addressing ED isn’t always simple since it often involves a complex interplay of physical, hormonal, and psychological factors. Yet, trying these tactics can’t hurt, as their benefits will extend to your overall health while increasing your odds of combatting ED.

Stem Cells Restore Erectile Function after Prostate Removal

Stem Cells Restore Erectile Function after Prostate Removal

For some men with prostate cancer, surgery to remove the prostate gland can be curative. The surgery to remove the entire prostate gland, called radical prostatectomy, can improve survival. If performed early, radical prostatectomy can prevent metastatic prostate cancer. While men who qualify for this surgery often jump at a chance to cure prostate cancer, radical prostatectomy comes with a price—it almost always causes erectile dysfunction. Here we talk about how Stem cells restore erectile function after prostate removal.

Even under the best surgical conditions, most men experience at least temporary erectile dysfunction after radical prostatectomy. While some men can regain erectile function by using oral ED treatments, as many as 3 out of 5 men continue to have poor erections and/or difficulty with orgasm months to years after radical prostatectomy.

In an attempt to find a way to treat this serious issue, researchers in France conducted a clinical trial to test whether mononuclear cells treatment could improve erectile function in men who had undergone radical prostatectomy and developed erectile dysfunction (INSTIN, INtra-cavernous STem-cell INjection clinical trial, NCT01089387). Mononuclear cells are a type of stem cell that can become many other cells, including nerve or blood vessels cells. The researchers collected mononuclear cells from the bone marrow of affected men and injected these cells into the patient’s own penile tissue (i.e. autologous stem cell infusion). The researchers then followed the men for 6 to 12 months to track whether the mononuclear cells helped improve erectile function.

The first phase of the phase 1/2 clinical trial was designed to assess the safety of the treatment. No patients in the trial experienced any side effects from treatment. Likewise, prostate cancer did not return any of the men within one year after treatment (and perhaps longer, the men were only followed for one year at the time of the report).

Within six months of treatment, men treated with the bone marrow stem cells had a significantly better erectile function and satisfaction with sexual intercourse. While the benefit was still present after the 12 months, the erectile function was not quite as good as it was at six months after treatment. This suggests injections may need to be repeated every six months to maintain maximal benefit.

These results are incredibly encouraging for men with erectile dysfunction caused by radical prostatectomy. While future clinical trials should contain a control group and larger numbers of men, these phase 1/2 clinical trial results pave the way for such research. These findings also suggest men who have life-saving prostate cancer surgery may be able to regain erectile function after surgery through stem cell treatment.

Reference: Yiou, R. et al. (2017). Intracavernous Injections of Bone Marrow Mononucleated Cells for Postradical Prostatectomy Erectile Dysfunction: Final Results of the INSTIN Clinical Trial. European Urology Focus. 2017 Dec;3(6):643-645.

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