by Stemedix | Mar 25, 2024 | Osteoarthritis, Pain Management, Regenerative Medicine, Stem Cell Research, Stem Cell Therapy
Living with osteoarthritis pain can be debilitating. You might feel barred from activities you previously enjoyed. With osteoarthritis, everything feels more difficult, including playing with your grandkids, enjoying sports, and walking in nature.
Addressing osteoarthritis pain involves a combination of lifestyle changes, modern scientific therapies, and medications. Here are some of the ways you can get relief from the pain and discomfort osteoarthritis brings to your life.
The Root Cause of Osteoarthritis
Arthritis is an inflammatory joint condition that currently has no cure. If you have osteoarthritis, your body experiences cartilage degeneration. This means the spongy tissue that connects your bones together is starting to break down.
Bone Friction and Damage
When enough cartilage is lost, the friction of your bones rubbing together causes pain, inflammation, and discomfort. Your ligaments start to stretch in painful, unhealthy ways.
Osteoarthritis operates in two ways. Cartilage breakdown causes bone friction, which increases your pain levels. Bone friction also causes serious bone damage that worsens your pain.
Because of these stressors, osteoarthritis pain can be debilitating. This condition can be progressive, getting worse as your joints and ligaments become stressed due to lack of cartilage. If you get proper treatment, however, you may get rid of your symptoms altogether.
There are a few risk factors for developing osteoarthritis. With proper treatment, you can go into remission and experience far fewer painful symptoms.
Who Gets Osteoarthritis?
What causes your cartilage to break down in the first place? The answer is more complex than you might expect. Some people are more susceptible to joint and cartilage damage than others.
Older Adults
Age is a major risk factor for developing osteoarthritis. Patients who are 40 or older are more likely to develop this condition.
Throughout your life, your joints and connective tissues experience “wear and tear,” and the effects accumulate as you age. This can create problems with your cartilage’s structural integrity, eventually leading to osteoarthritis. It makes sense that aging adults experience higher rates of this inflammatory health condition.
People With Sudden Injuries
You may develop osteoarthritis if you’ve experienced a sports injury or sudden joint impact. Injuries can harm the cartilage that connects your joints, increasing your risk of developing this condition.
If you’re an older adult who played sports in your younger years, you may notice symptoms of osteoarthritis popping up as you age. Car crash victims and people with traumatic joint injuries are also vulnerable.
Obese Patients
Obesity raises your risk for this degenerative disorder. The more extra fat you carry, the more stress and pressure your joints experience. Over time, excess body weight can break down connective tissues in your knees, legs, and feet.
Since osteoarthritis is an inflammatory condition, being obese can exacerbate the symptoms. If you eat a poor diet full of processed foods and refined sugars, your body is more vulnerable to inflammation. These conditions make osteoarthritis symptoms even more debilitating.
How to Get Relief from Osteoarthritis Pain
The joint pain and discomfort that come with osteoarthritis can impair your daily life. If you like to be active and move around a lot, this disease may force you to change your lifestyle. Luckily, you have options when it comes to osteoarthritis pain relief.
From over-the-counter pain medications to natural holistic remedies, there’s no shortage of osteoarthritis pain relief. You can choose what works best with your personal preferences and lifestyle.
Pharmaceutical Treatments
Most physicians recommend over-the-counter anti-inflammatory drugs to manage osteoarthritis pain. If you have debilitating discomfort, some doctors will prescribe stronger pain medication. These treatments are usually intended for short-term use.
While medication covers up the pain you’re experiencing, it doesn’t solve the underlying problem. You likely won’t get long-term relief from medication alone.
Stem Cell Therapy
Stem cell treatments for osteoarthritis may reduce inflammation and pain over time. This evidence-based therapy uses special “blank” cells to regenerate damaged tissues. Since osteoarthritis is a degenerative condition, stem cell therapy is a potentially effective solution to cartilage breakdown.
Stem cells come from the human body. These treatments are completely drug-free and use the natural powers of your body’s wound-healing process. Patients who seek stem cell therapy for osteoarthritis may notice significant improvements in their comfort levels after a few weeks.
Specialized Massage
Massages can help improve blood flow to the affected areas. As a result, massage therapy may be a good supplemental tool for relieving osteoarthritis pain.
Many people experience better mobility after a few massage therapy sessions. A massage therapist specializing in osteoarthritis pain relief can help you feel more comfortable and mobile in your daily life.
Acupuncture
Acupuncture is a holistic solution for joint pain osteoarthritis causes. Patients from different backgrounds and with various health problems have experienced pain relief from acupuncture. This therapy uses tiny needles to relax your muscles and redirect your brain’s pain signals.
Acupuncture should be used as a supplement to other types of therapy. It can provide short-term relief, but much like medication, it doesn’t treat the root cause of your osteoarthritis pain.
Lifestyle Changes
Lifestyle changes offer effective, natural solutions to your daily discomfort. Nutrition, weight, sleep, and stress management all play large roles in osteoarthritis pain relief.
Your body needs the right nutrients to control inflammation and accelerate wound healing. You also need plenty of sleep and stress management to maintain a healthy body. Any or all of these factors can improve or worsen your osteoarthritis pain.
As a rule of thumb, you should prioritize:
- Healthy weight management
- Good nutrition
- Sleep quality and quantity
- Stress relief
- Gentle daily exercise
These lifestyle factors will all help your body recover from osteoarthritis attacks. You may be able to prevent the inflammation from getting worse by improving these areas of your life.
Experience Osteoarthritis Pain Relief to Enjoy Healthy Movement Again
You’re understandably ready to get back to doing what you love. Managing your osteoarthritis pain doesn’t have to take over your life. Live a healthy lifestyle as you consider different therapies and treatments to take the edge off of your joint pain.
by admin | Feb 15, 2024 | Osteoarthritis, Exosomes, Extracellular Vesicles, Mesenchymal Stem Cells, Stem Cell Research, Stem Cell Therapy
Osteoarthritis (OA) is the most common form of arthritis and is estimated to affect nearly 365 million people worldwide. Characterized as an inflammatory disease, OA slowly progresses over time and results in the gradual loss of the protective cartilage found on the ends of the bones.
While the specific cause of OA has yet to be determined, a growing body of evidence suggests the chondrocyte inflammatory response resulting from elevated levels of pro-inflammatory cytokines is a critical factor in the development and progression of OA.
Recent evidence also suggests that mesenchymal stem cell-derived exomes (MSCs-Exos) exhibit beneficial anti-inflammatory responses in several inflammatory diseases, including OA.
In this study, Wang et al. explore the role of human umbilical cord-derived MSCs-Exos (hUC-MSCs-Exos) in treating the inflammation of chondrocytes and its related mechanisms.
As part of this study, the authors report that supplementing the observed chondrocyte inflammation models with hUC-MSCs-Exos demonstrated the ability to reduce the inflammation of chondrocytes caused by the inflammatory factor IL-1β.
Additionally, activation and polarization of synovial macrophages to M1 phenotypes also contribute to the progression of OS. As part of this study, Wang et al. report that hUC-MSC-Exos demonstrated a protective effect against M1 macrophage-induced chondrocyte damage and cell death.
Wang et al. indicate that the results of this study confirm the anti-inflammatory effects of hUC-MSCs-Exos in the human articular chondrocytes inflammation model. The authors also conclude that hUC-MSCs-Exos may be used as a potential cell-free treatment for chondrocyte inflammation in OA.
Source: Wang S, Jiang W, Lv S, et al. Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes. Aging (Albany NY). 2023;15(18):9544-9560. doi:10.18632/aging.205034
by Stemedix | Feb 12, 2024 | Age Management, Health Awareness, Osteoarthritis, Pain Management, Regenerative Medicine, Stem Cell Therapy
The National Library of Medicine states that 10% of people over 55 in the United States have disabling knee osteoarthritis. If you are one of these people, finding the right treatment can be challenging, especially if you don’t want to become dependent on pain medications or go through an invasive knee surgery.
For some, surgery can be the only option, but for many others, some management strategies and less invasive options could offer relief from symptoms.
What Is Knee Osteoarthritis? Understanding the Symptoms and Causes
Osteoarthritis of the knee occurs when the cartilage in your knee joint starts to break down. This causes the bones to rub together, leading to stiffness, swelling, and pain that can interfere with your life.
Women are more likely to develop knee osteoarthritis, as are people over the age of 40, but genetics and other factors can cause it in younger people.
Pain is the most common symptom of this condition, but there are other signs, including:
- A puffy or swollen knee
- Hearing a grinding or cracking noise when you move
- Knee stiffness
- Knee that locks up or feels stuck
- Knee that feels wobbly
There can be many causes of knee osteoarthritis. Having a body mass index of 30 or more puts pressure on your knees and can cause inflammation. This inflammation can lead to arthritis or make existing arthritis worse.
You can also develop this condition if you suffer a knee injury or have a prior knee injury. If you have close relatives who’ve had knee osteoarthritis, you’re also more likely to struggle with this problem.
If you frequently put stress on your knees, whether by playing sports or as a result of your job, you can also develop osteoarthritis in your knee.
Treating Knee Osteoarthritis
If you have signs of osteoarthritis, there are a number of treatment options you can talk to your doctor about.
Maintaining a Healthy Weight
If you have risk factors that can increase your chances of developing knee osteoarthritis or if you already have the condition, ensuring your weight is healthy is vital. The Arthritis Foundation states that being just 10 pounds overweight can put 15 to 50 pounds of extra weight on your knees. That makes the development of osteoarthritis more likely.
Losing weight allows you to reduce some of that strain on your knee joints. Aside from that, losing weight also helps reduce inflammation throughout the body, which can help with arthritis.
Getting Regular Exercise
Those who have knee osteoarthritis can also benefit from getting regular exercise. It can help you lose weight, increase your mobility, and build up muscle strength to support your knee joints.
It is important to choose low-impact aerobics options that are suitable for your health level. These can include:
- Swimming
- Cycling
- Yoga
- Stretching
- Walking
Riding a stationary bike can be very helpful for maintaining strength in the hamstring muscle groups without putting extra pressure on your knee. It’s best to have a doctor or physical therapist at your side to help you put together an exercise plan.
Using Medications for Pain and Swelling Relief
For people who are dealing with a lot of pain and swelling, one option is to turn to medications. Over-the-counter painkillers are one option, and many of them offer anti-inflammatory properties that help with the swelling that might be impeding you from moving freely.
Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, as well as acetaminophen for those who can’t take NSAIDs, can be helpful for osteoarthritis pain.
If these aren’t effective, there are prescription options your doctor could recommend. These may include opioids and even injectable steroids for people with severe inflammation.
Prescription medications can cause side effects. Because they don’t actually do anything to heal your body and only help you manage the symptoms of knee osteoarthritis, the moment you stop taking them, the pain and inflammation will usually return.
Turning to Regenerative Medicine
One promising option for the treatment of knee osteoarthritis is regenerative medicine. It is a field of medicine that strives to harness the body’s natural healing powers to make them work in the areas where you need them most. There are a number of treatments, including platelet-rich plasma therapy and stem cell therapy.
Platelet-rich plasma (PRP) therapy uses the platelets in your blood, which have clotting abilities and can stimulate many healing processes.
By separating the platelets from the other components in your blood, like white blood cells, red blood cells, and more, and concentrating them in the liquid portion of your blood, you can give the treatment area a boost of growth factors. These growth factors encourage the healing process.
Stem cell therapy uses stem cells gathered from your fat or bone marrow to stimulate the regeneration of damaged tissue. Stem cells have endless regenerative powers, and they’re able to transform into the exact type of cells you need.
Regenerative medicine offers the chance to decrease inflammation in the area, allowing blood to flow more freely and bring with it oxygen and nutrients. Less inflammation can also mean less pain because you aren’t putting as much pressure on nearby nerves.
Another benefit of regenerative medicine is that it is minimally invasive, so you don’t have to worry about a long recovery period. Most people are good candidates for this type of procedure as well.
Choosing Surgery
In severe cases, surgery may be the only way to treat knee osteoarthritis. You can get arthroscopic surgery, which is less invasive because it uses an arthroscope. This is a small camera that guides the surgeon in repairing the damaged area.
A total knee replacement can be another option. It can be done as minimally invasive or open surgery, depending on your overall health.
Stem cell therapy can still apply as a post-surgery option to help speed up recovery and manage inflammation and pain during the healing process.
Getting Relief from Knee Osteoarthritis Symptoms
If you are struggling with knee osteoarthritis, getting relief from the inflammation and pain can mean considering all available treatment options. By turning to your doctor, you can make sure you have the best chance of achieving the help you deserve.
by admin | Feb 8, 2024 | Osteoarthritis, Mesenchymal Stem Cells, Stem Cell Research, Stem Cell Therapy
Osteoarthritis (OA) is the most common form of arthritis and occurs as a result of the protective cartilage, found on the ends of the bones, degenerates over time. While OA can occur in any joint, it is most commonly found to occur in the hands, hips, spine, and knee.
An estimated 365 million people worldwide are currently living with some form of knee OA. Although there have been improvements in conventional treatment methods that have shown some benefit, there is no therapy or drug that can prevent or treat the development of OA in the knee.
Recent phase I/II trials using mesenchymal stromal cells (MSCs) derived from bone marrow (BM) and adipose tissue have demonstrated the feasibility, safety, and clinical and structural improvements in focal or diffuse disease.
Considering the findings of these phase I/II trials, Orrego et al. conducted this study to better assess the safety and efficacy of the intra-articular injection of single or repeated umbilical cord-derived (UC) MSCs in knee OA.
The target population of this study was individuals between the ages of 40-65 with symptomatic knee pain for at least 3 months with grade 1-3 Kellgren-Lawrence radiographic changes in the targeted knee, without meniscus rupture.
The authors divided participants of this study into three specific groups, a control group which received intra-articular knee injections of hyaluronic acid (HA) at baseline and 6 months; the MCS-2 group, which received UC-MSCs at baseline and 6 months; and the MSC-1 group, who received UC-MSCs at baseline followed by placebo injection at 6 months.
At the conclusion of this study’s 12 months follow-up period, Orrego et al. found that the group with repeated UC-MSC intra-articular injections, or MCS-2, experienced significant clinical changes in total WOMAC, pain component, and VAS when compared with the control group. The authors also found that only patients in the MSC groups experienced significant amelioration of pain and disability at 6 and 12 months. The authors also reported no safety signals were detected in the experimental groups as compared with the HA controls.
Considering these findings, the authors conclude that the use of MSCs produces anti-inflammatory properties in response to tissue damage or inflammation that demonstrates suppressive effects on the maturation of dendritic cells, macrophages, Natural Killer, and cytotoxic T-lymphocytes.
While these results appear promising, the authors point out that even if all MSC trials report a good safety record and improvements in cartilage quality, the use of autologous cell therapy does come with some limitations. Among these limitations include a dramatic decline of bone precursor cells when these cells are derived from bone marrow. Studies have also shown reduced chondrogenic activity of MSCs in cultures obtained from individuals with advanced forms of OA. For these reasons, and considering the findings in this study, the authors highlight that allogeneic sources of MSCs have been shown to express superior clonogenicity, migration, and paracrine capacities.
The authors conclude that the repeated UC-MSC dose strategy utilized in this study led to a favorable safety profile and improved clinical results for the treatment of long-term pain in knee OA patients.
Source: Jose Matas, Mario Orrego, Diego Amenabar, Catalina Infante, Rafael Tapia-Limonchi, Maria Ignacia Cadiz, Francisca Alcayaga-Miranda, Paz L. González, Emilio Muse, Maroun Khoury, Fernando E. Figueroa, Francisco Espinoza, Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial, Stem Cells Translational Medicine, Volume 8, Issue 3, March 2019, Pages 215–224, https://doi.org/10.1002/sctm.18-0053
by Stemedix | Jan 29, 2024 | Parkinson's Disease, Lyme's Disease, Osteoarthritis, PRP, Regenerative Medicine, Stem Cell Therapy, Stroke
Orthopedic rehab is a type of rehabilitation designed to help people who have been injured, had surgery, or have degenerative conditions. Its goal is to aid patients in regaining mobility, balance, and function in their musculoskeletal system. Orthopedic rehab also focuses on finding ways to alleviate pain.
If you have suffered an injury or gone through surgery, or if you have a degenerative condition that affects your mobility, orthopedic rehab could be the right option for you. But what can it help with, and what can you expect from the process?
What Conditions Can Orthopedic Rehab Help With?
Orthopedic rehab is a conservative treatment that can benefit patients of all ages who are suffering from issues that affect their range of motion, joint flexibility, muscle strength, and body function.
It can help with conditions like:
- Joint pain
- Arthritis
- Parkinson’s disease
- Lyme disease
- Scoliosis
- Stroke
- Spinal stenosis
- Knee instability
- Carpal tunnel
- Osteoporosis
- Sciatica
This type of rehab is usually essential for those recovering from joint replacement surgeries and similar procedures. It can also help with pelvic floor issues.
Orthopedic physical therapy is important after certain surgical procedures, including those like:
- Knee replacement
- Rotator cuff replacement
- Knee arthroscopy
- Hip replacement
- Cancer surgery
- Heart surgery
This type of rehab can help to normalize your gait, improve your range of motion, and even prevent excessive scar tissue buildup.
It’s also helpful for people who’ve suffered a chronic injury. A chronic injury is damage that occurs over time, generally because of small movement patterns that lead to repetitive injuries to your bones, joints, or tendons. Tennis elbow or carpal tunnel are examples. With rehabilitation, you can learn how to move without injuring yourself.
Benefits of Orthopedic Therapy
Orthopedic therapy helps increase your mobility. Mobility can be limited after an operation, while recovering from an injury, or when dealing with degenerative diseases. This type of therapy utilizes stretching and exercise strategies to slowly increase your range of motion.
Orthopedic therapy also helps with pain management so that you don’t have to rely as much on pain medications. Therapists can massage the treatment area, increasing circulation and decreasing inflammation. Some orthopedic therapy options use ice packs for dealing with inflammation and heat packs for loosening tension.
Better blood circulation, which orthopedic therapy helps with, also brings oxygen and nutrients to the treatment area. This makes it easier for injuries to heal.
You can also help avoid re-injuring yourself. Therapy assists by teaching you to move safely while also showing you how to gain strength in the area.
Types of Treatments Offered in Orthopedic Therapy
When you turn to orthopedic therapy, you can benefit from a few different types of treatments.
Hot and Cold Therapy
Orthopedic therapy often relies on thermotherapy (heat therapy) and cryotherapy (cold therapy) to treat musculoskeletal swelling and pain.
E-Stim
Electrical stimulation can help diminish pain. With E-stim, your therapist attaches a device to the treatment area. The two main types of devices they may use include TENS, which uses low-voltage electrical currents to offer pain relief, and NMES, which sends electrical impulses to the nerves.
Exercise Therapy
You will get an exercise plan that helps you increase mobility, strength, and balance. You will get a chance to practice them with the therapist so that you can then repeat them at home.
Soft Tissue Manipulation
Soft tissue manipulation is a kind of manual physical therapy in which your physical therapist massages your ligaments, fascia, and muscles. It helps optimize muscle function while also decreasing tension. It may also be effective at improving blood circulation.
Laser or Light Therapy
Low-level lasers and light therapies can help with muscle performance. They have the potential to reduce muscle fatigue and help tissues repair after an injury.
Platelet-Rich Plasma Therapy
Platelet-rich plasma (PRP) therapy uses the growth factors in your blood to encourage healing at the treatment area. It’s an option that often complements other orthopedic therapies.
What an Orthopedic Rehab Plan Can Look Like
The orthopedic plan your healthcare provider recommends will consider your injury, overall health, abilities, and goals. You will have a personalized and unique program that your team can adjust as you progress through it.
The first step is to determine whether you can benefit more from an inpatient or outpatient orthopedic rehab program. In more complex situations, inpatient care is usually the right choice, while outpatient options are better suited for minor injuries.
Most patients start each rehab session with physical therapy. These sessions can last between 30 and 60 minutes. Those with more serious issues can begin lying on an exam table while the therapist performs some passive exercises. You may then have to perform the same exercises on your own.
Your therapist may then continue to show you more stretches and exercises to incorporate into your home routine. Some of the exercises may even rely on weights or bands.
Orthopedic rehab also focuses on helping patients perform everyday tasks. If you have trouble walking, the session can involve relearning how to do this correctly to avoid falls and further injuries. If you have had a joint replacement, you may relearn to walk with the support of the therapist before moving on to walkers and other devices.
Patients who need to improve grip strength will likely spend a significant amount of time in the session practicing grabbing things of increasing weight.
For patients who have degenerative diseases, balance exercises are particularly useful. They can help the patient better understand where their body is in space. Some of these exercises can include standing on one foot and raising or lowering a foot or knee.
Getting the Care You Need
Orthopedic rehab offers the chance to regain your strength, balance, range of motion, and more after suffering an injury or going through surgery. It is also useful in the process of managing degenerative diseases like Parkinson’s.
By combining various types of therapies, including PRP therapy, you have the chance to get relief from pain while also preventing future injuries.
by admin | Jan 4, 2024 | Osteoarthritis, Exosomes, Mesenchymal Stem Cells, Stem Cell Research, Stem Cell Therapy
Osteoarthritis (OA) is a chronic joint condition that causes pain and lack of mobility through the progressive degradation of joint cartilage. While there are several current pharmaceutical, physical therapy, and surgical treatments to address the symptoms of OA, researchers are interested in developing new therapeutic treatment approaches to address the relentless progression of the condition.
Considering their documented biocompatibility, immunomodulatory properties, and ability to precisely target specific cells and tissues, exosomes have recently emerged as a promising therapeutic option as a drug delivery system (DDS) for the treatment of OA. Specifically, these exosome-based strategies have demonstrated a safe and effective way to enhance cartilage repair, mitigate inflammation, and alleviate the persistent pain associated with OA.
While the benefits of exosome-based DDSs have been demonstrated in numerous studies, according to the author of this review, the specific application of this option for the purpose of treating OA has not been sufficiently explored.
In this review, Lu et al. summarize the emerging developments surrounding exosome-based DDSs of OA and highlight the present challenges associated with this evolving therapeutic option.
Recent studies have demonstrated the benefit of using exosomes for the delivery of drugs designed to treat OA. Specifically, researchers have found that exosomes derived from mesenchymal stem cells (MSCs) are able to be effective carriers for the delivery of specific molecules that lead to the promotion of chondrogenesis and improvement in cartilage regeneration. These same exosomes have also demonstrated themselves to be effective carriers for the localized delivery of anti-inflammatory drugs known for their potent anti-inflammatory and immunosuppressive effects.
Other studies show the potential of exosomes as an effective way to deliver growth factors to the affected joint in a targeted and sustained manner. The same exosomes have also demonstrated promise as a platform for gene delivery to areas affected by OA; a few of the notable advantages include the ability to safeguard genetic material from degradation and enable targeted delivery to specific cells and tissues.
While there is seemingly unlimited potential for using exosomes as DDSs in OA treatment, Lu et al. also call attention to several technical challenges and limitations that need to be addressed in order to fully maximize their potential and to ensure their safe application. These challenges and limitations include figuring out how to obtain a consistent supply of high-quality exosomes, developing effective methods that allows for efficient loading and controlled release of therapeutic molecules within exosomes, and a current lack of comprehensive long-term data regarding the safety and biocompatibility of exosome-based therapies.
Despite these challenges and limitations, the authors conclude that exosomes have emerged as highly promising candidates for drug delivery in OA therapy and offer numerous advantages over conventional delivery systems.
Source: Jun Lu, Yan Zhang, Xinquan Yang, Hongmou Zhao, Harnessing exosomes as cutting-edge drug delivery systems for revolutionary osteoarthritis therapy, Biomedicine & Pharmacotherapy, Volume 165,2023,115135, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2023.115135.
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