by admin | Nov 4, 2022 | Stem Cell Therapy, Mesenchymal Stem Cells, Rheumatoid Arthritis, Stem Cell Research
Mesenchymal stem cells (MSCs) have demonstrated the ability to differentiate into a number of different cells; they also demonstrate immunomodulatory properties that have great potential for use as a stem cell-based therapeutic treatment option and for the treatment of autoimmune diseases – including rheumatoid arthritis (RA).
RA is a chronic and debilitating inflammatory disorder that not only affects the joints, muscles, and tendons, but also damages a number of other body systems, including the eyes, skin, lungs, heart, and blood vessels[1]. It is estimated that roughly 1.5 million Americans are afflicted by RA. While the exact cause of RA is not yet fully understood, the condition is one of over 80 known autoimmune diseases occurring as a result of the immune system mistakenly attacking the body’s own healthy tissue.
Current treatment of RA primarily involves the use of steroids and antirheumatic drugs used primarily to manage associated symptoms of the condition, rather than treat the condition itself. These drugs are also commonly associated with a number of unwanted side effects with users often developing resistance to the medication after prolonged use.
Considering the relative ineffectiveness of drugs designed to treat RA and RA-associated symptoms, scientists have turned to investigate the use of MSC-based therapy as a potential treatment for RA.
As part of this investigation, Sarsenova et al. examined both conventional and modern RA treatment approaches, including MSC-based therapy, by examining the connection between these stem cells and the innate and adaptive immune systems. This review also evaluates recent preclinical and clinical approaches to enhancing the immunoregulatory properties of MSCs.
Through a number of in vitro studies, researchers have realized that MSCs have the ability to inhibit the proliferation of effector memory T cells which, in turn, prevents the proliferation of inflammatory cytokine production. Additionally, these studies have also demonstrated that MSCs are able to modulate functions of the innate immune system by inducting the inflammatory process and activating the adaptive immune system.
Preclinical studies have demonstrated the ability of MSCs to suppress inflammation both through interactions with cells of the immune system and through paracrine mechanisms. This has been demonstrated to be very important as cells of the innate immune system have been shown to have an important role in both the development and progression of RA.
While a number of clinical studies evaluating the effectiveness of MSC-based therapies for the treatment of RA were still ongoing at the time of publication, the nine completed studies primarily demonstrated that using MSCs for the treatment of RA is safe, well tolerated in both the short and long-term, and provides clinical improvements in RA patients.
Despite the many positive and promising outcomes observed through these clinical trials, the authors of this review also point out some limitations associated with the treatment of RA with MSCs. These limitations include many of the referenced studies lacking a placebo control, low enrollment in some studies, and a lack of optimal protocol (for both MSC sourcing and route of administration) for RA treatment with MSCs.
Considering these limitations, Sarsenova et al. point out the need for more well-defined and effective therapeutic windows for the treatment of RA with MSCs, including MSC priming to promote an anti-inflammatory phenotype, in a future study as a way to better understand the perceived benefits of a stem-cell therapy for the treatment of RA and other autoimmune diseases.
Source: “Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis.” 27 Oct. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584240/.
[1] “Rheumatoid arthritis – Symptoms and causes – Mayo Clinic.” 18 May. 2021, https://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/symptoms-causes/syc-20353648. Accessed 5 Oct. 2022.
by Stemedix | Oct 31, 2022 | Regenerative Medicine, Athletic Injury
You might suffer from knee pain due to the strain of everyday activities, sports injuries, or accidents. Regardless of the cause, knee pain often worsens over time and can become so debilitating that walking or standing becomes painful. Here we will discuss how regenerative medicine can help damaged knees.
Where Does Knee Damage Occur?
Knee damage can result from continuous stress on the joint or from an injury. Overuse due to certain activities can cause tendinitis (inflammation in the tendons). Excess pressure or stress on the joint can lead to osteoarthritis, a condition in which the joint’s cartilage wears away.
Injuries that can damage the knee include sprained ligaments, strained muscles, or torn cartilage. Any injury to the knee can cause pain, swelling, stiffness, and difficulty walking. If you experience repeated knee injuries, you may be more likely to develop osteoarthritis.
What Is Regenerative Medicine?
Regenerative medicine, also known as stem cell therapy, harnesses the unique qualities of stem cells to repair and restore damaged tissue in the body.
Some cells in the body, like skin cells, constantly divide to create new cells, a process called mitosis. When those cells divide, they make two new, identical cells called daughter cells. Other cells in the body, such as neurons or certain heart cells, never divide at all.
Stem cells stand out as the only cells in the body capable of dividing to create various specialized cells, a process called differentiating. Since many specialized cells do not divide, stem cells are essential to the body’s health.
During stem cell therapy, stem cells are extracted from a patient’s bone marrow or body fat. They are then administered into injured areas, triggering tissue to repair and restore itself. The ability of stem cells to divide into other types of cells gives them impressive healing abilities.
How Can Stem Cell Therapy Help Repair Damaged Knees?
Currently, physicians are using stem cell therapy to promote healing in knee injuries, injecting the cells into damaged joints to accelerate the body’s repair process and foster a complete recovery.
Patients with osteoarthritis experience most of their pain due to a lack of cartilage. Irritation and inflammation can occur when the bones, muscles, and other joint tissues move without the cushioning effects of cartilage.
Stem cell treatments protect and heal the joint tissue affected by cartilage loss, keeping them from further affecting mobility and creating new knee issues, such as bone spurs.
Many patients are exploring the options of regenerative medicine to help manage their pain and inflammation, and in some cases, rebuild and repair damaged tissues. Find out how this new alternative medicine may help you. To learn more about how regenerative medicine can help damaged knees, contact a care coordinator at Stemedix today!
by Stemedix | Oct 24, 2022 | PRP, Stem Cell Therapy
Stem cell therapies and platelet-rich plasma (PRP) are regenerative medicine treatments that use the body’s natural healing mechanisms to repair damage and restore function. Unlike traditional medicine, which often works to alleviate symptoms instead of targeting the source of pain or illness, regenerative treatments aim to heal the underlying cause of pain or dysfunction. PRP & stem cells often have overlapping benefits and sometimes are used interchangeably. However, the treatments have some significant differences.
What Is PRP Therapy?
Platelets are cells within the blood that identify damaged areas and bind together to start the healing process. Platelet-rich plasma comes from a sample of the patient’s blood placed in a centrifuge that separates and concentrates the platelets in the plasma.
Once concentrated, the PRP contains three to five times the platelets as a blood sample. Next, a physician administers the PRP into damaged or injured areas to expedite healing.
When you cut your hand, your platelets form a clot to stop the bleeding. The clot releases growth factors into the injured area to trigger the body’s repair response. The growth factors are released in varying intervals, drawing stem cells and new blood vessels to the injury site to promote healing through new blood and oxygen.
What Is Stem Cell Therapy?
Stem cells are found throughout the body, mostly lying dormant until there’s an injury that triggers them to react. Then, they’re the only cells in the body capable of division and differentiation. When stem cells divide, they create more stem cells. However, when stem cells differentiate, they make specialized cells, like blood or brain cells.
Like PRP, stem cells initiate the body’s healing response. But stem cells can also repair and regenerate damaged tissue. For example, stem cells can offer pain relief by restoring diseased or injured tissue with long-term results.
How Do the Treatments Differ?
The critical differences between stem cell therapy and PRP therapy come from how they work and where they’re most effective.
Platelet-Rich Plasma
PRP’s key benefit is the therapy’s ability to initiate and accelerate healing. The platelets’ growth factors can:
- Regulate inflammation
- Trigger the growth of new blood vessels
- Activate the nearby cells’ healing activities
- Protect healthy tissues
Since PRP mainly offers healing benefits, this therapy is often preferred to promote healing from musculoskeletal injuries.
Stem Cell Therapy
Stem cells go beyond repairing tissue and can also regenerate damaged cells. Since stem cells can serve all the functions of PRP and convert to any tissue the body needs, they can treat musculoskeletal injuries and degenerative conditions, such as arthritis.
Stem cell therapies have the capability to replace and repair tissues to remedy the source of pain or damage, making them a potentially more comprehensive and effective option that may be suitable for treating a broader range of conditions. To learn more about PRP & Stem Cells contact us today at Stemedix!
by admin | Oct 19, 2022 | Health Awareness
The terms “sell by,” “best by,” and “use by” are notoriously confusing. While many shoppers err on the side of caution, increasing grocery costs mean that understanding these dates can lead to savings.
What Your Food Labels Mean
Since there’s no federal standard for food labels, laws around product dates vary by state. Here’s what you can interpret from your food labels.
Best If Used By and Best If Used Before
The terms “best if used by” and “best if used before” do not refer to your food’s expiration date. Instead, these phrases refer to flavor and quality. Once the date after your “best by” label passes, the taste of the food may become compromised.
The “best by” labels can apply to any food category, including canned, boxed, frozen, or refrigerated.
Use By
“Use by” is a little clearer. The “use by” date refers to the last date when the food is at its highest quality. “Use by” generally only applies to perishable items, such as dairy and meat products or prepared foods.
Sell By
“Sell by” dates are more about inventory control than expiration. You can consume foods after the “sell by” date, but they should no longer carry them in stores. Typically, dairy products are suitable for a week after their “sell by” date, and eggs are safe to consume for three to five weeks after their “sell by” date.
Expiration Date
Food may be assigned an expiration date due to loss of function after that date – like yeast that won’t rise – or changes in the safety or texture of the food.
Foods assigned an expiration date include:
- Baby formula
- Baby food
- Vitamins
- Over-the-counter medications
- Cake mixes
- Baking powders
While dates are helpful to track how long you’ve kept a food, unless the dates clearly state that the food expires, the best way to determine whether a food is spoiled is by examining it for changes in smell, color, texture, or consistency.
Additionally, the best way to keep your meats, soups, and casseroles longer is to freeze them. Bacteria can’t grow at frozen temperatures, so frozen meals maintain their safety for years.
For more health awareness blogs, please visit www.stemedix.com/blog.
by Stemedix | Oct 17, 2022 | Uncategorized
Stem cells are unique in the body, as they are the only type of cells that can divide to create a new, specialized cell. For example, a stem cell can divide and make a brain, muscle, or heart cell. Some stem cells can also repair damaged tissue or reduce...
St. Petersburg, Florida
