The Safety and Efficacy of Stem Cell Therapy For ALS

by Matson Huff | May 16, 2022 | ALS, Stem Cell Therapy

As science continues to uncover the benefits of stem cell therapy, many trials and studies are bringing their focus to conditions with limited treatment options. The neurodegenerative condition amyotrophic lateral sclerosis (ALS) is one of the conditions that greatly needs new treatment methods to slow its progression. Fortunately, recent clinical trials offer promising results. Here we will discuss Stem cell therapy for ALS.

What Is ALS?

ALS affects the nerve cells present in the brain and spinal cord. In ALS patients, the motor neurons that carry messages from the brain to the spinal cord and then to the body’s muscles progressively die off. As they die, the brain can no longer communicate with the muscles, so patients lose muscle action. 

The loss of muscle control may begin with walking and standing, but patients can lose the ability to move, speak, eat, and breathe over time. 

How Can Stem Cell Therapy Help ALS Patients?

Stem cells are the building blocks of cells. When prompted to divide, stem cells can either form more stem cells or become specialized cells, such as brain cells or nerve cells. Those new, specialized cells have the potential to repair and replace damaged cells. 

Stem cell therapy is an inspiring option in treating ALS since researchers believe the treatment could support new cell growth and help manage the body’s immune system response. Additionally, stem cells offer the potential to regenerate the damaged motor neurons that are characteristic of the disease. 

Clinical Trial Results

In an analysis of six clinical trials that examined the benefits of stem cell treatments in slowing the progression of ALS, all six trials showed stem cell therapy slowed the advancement of the disease. However, in two studies, the results were not statistically significant. 

All of the studies that followed patients for six months after their stem cell treatments saw significant differences in the results of patients’ ALSFRS-R reports. Patients within the treatment groups experienced a notable slowing in the disease’s progression. In examining the methodologies of the studies analyzed, there are techniques and types of stem cells that show improved results. Notably, the most effective delivery of stem cells to slow ALS in patients is through injections into the fluid-filled space surrounding the spinal cord. In addition, studies using mesenchymal stem cells (MSCs) also saw more significant results than other stem cell therapies. To learn more contact a care coordinator today at Stemedix!

What Are The Symptoms of ALS?

by Matson Huff | Apr 4, 2022 | ALS, Stem Cell Therapy

Amyotrophic lateral sclerosis (ALS) is a progressive disease of the nervous system that targets the nerve cells in the brain and the spinal cord. Also known as Lou Gehrig’s disease, the condition eventually causes patients to lose muscle control. While ALS currently has no cure, early identification allows patients to use various therapies to delay the advancement of symptoms. Here we will answer a very common question ” what are the symptoms of ALS? “. Keep reading to learn more!

Early ALS Symptoms

Since ALS is a progressive disease, symptoms appear gradually, and patients often ignore early signs. The progression of ALS differs in each patient, as it can target varying neurons. However, there are some common early symptoms, including:

• Slurred speech
• Trouble gripping items with hands
• Issues swallowing
• Stumbling
• Muscle cramps
• Poor posture
• Trouble holding up your head
• Muscle stiffness

ALS symptoms typically begin in the extremities and the limbs before spreading through the body. Both early and later stages of ALS have no pain. 

Advanced ALS Symptoms

As ALS spreads through the body, symptoms worsen. These symptoms include:

• Less muscle mass
• Struggles with chewing and swallowing
• Weaker muscles
• Poor or slurred speech
• Trouble breathing

Later stages of ALS affect more of the patient’s muscles and movement. 

What Causes ALS?

While the exact cause of ALS is unknown, about 5–10% of ALS patients inherit a familial ALS form. Children of familial ALS patients have a 50/50 chance of developing the disease. 

Most scientific theories on the cause center on a complex interaction between environmental and genetic factors for those with ALS and no familial connection. Smoking, environmental toxin exposure, and military service all appear to contribute to the development of the disease, although researchers aren’t entirely sure how or why.

How Can Patients Manage ALS Symptoms?

During the early stages of ALS, patients benefit from various therapies to delay the progression of symptoms. Physical therapy, occupational therapy, and speech therapy help patients improve their quality of life as the disease progresses.

Physical Therapy

Physical therapy can extend the amount of time a patient can walk unassisted. Physical therapists work with patients to retain strength in their larger muscle groups and to maintain balance and gross motor skills. 

Occupational Therapy

Occupational therapy focuses more on smaller muscle movements, such as using eating utensils, brushing teeth, and getting dressed. Occupational therapists may also work with patients to find alternative methods for completing tasks as specific muscles weaken.

Speech Therapy

Speech therapy assists ALS patients in retaining their clarity of speech and swallowing and chewing as the tongue begins to weaken.

While early ALS symptoms, such as an occasional muscle cramp or feeling of weakness, are no cause for concern, if you’re noticing weakness in your hands or feet for days, it’s worth seeing a physician. Some early symptoms of ALS may also be symptoms of other, less-serious health concerns.Many patients are exploring the alternative option of stem cell therapy. This regenerative medicine therapy can help manage symptoms and help slow the progression of the condition. Mesenchymal stem cells may offer a potential benefit in how they target damaged tissues, help in neuronal and non-neuronal cell replacement, trophic factor delivery, and modulation of the immune system. If you would like to learn more about your options for treatment of ALS contact a care coordinator at Stemedix today!