Mesenchymal Stem Cells

January 5, 2023

Evaluating The Immunomodulatory Effects of High Dose Intravenous Administration of Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells

Diabetes, Mesenchymal Stem Cells, Regenerative Medicine, Stem Cell Research, Umbilical Stem Cell, Wharton’s Jelly

Mesenchymal stem cells (MSCs) are multipotent fibroblast-like cells found throughout the body and have been found to have self-renewing and multilinear therapeutic potential by providing new cells for tissue repair by replacing damaged cells. Thought to stimulate repair and control the immune response through an expression of growth factors and other cytokines, MSCs are at…

December 20, 2022

Mesenchymal Stem Cells and Osteoarthritis

Mesenchymal Stem Cells, Osteoarthritis, Stem Cell Research

Osteoarthritis (OA) is the most common form of arthritis and affects an estimated 25% of adults in the United States. Characterized by pain, stiffness, and inflammation in the joints of the body, OA is most frequently observed in the knees, hands, hips, and spine. OA is one of the leading causes of disability with an annual…

December 6, 2022

A Review of Circulating Mesenchymal Stem Cells

Mesenchymal Stem Cells, Stem Cell Research

Mesenchymal stem cells (MSCs) have been widely used in a number of applications designed to aid in the regeneration and healing of human tissue. Prized for their multipotent capacity to differentiate into a variety of other specific cell types, MSCs have consistently demonstrated the ability to seek out damaged tissue while also reducing inflammation and promoting…

November 11, 2022

Mesenchymal Stem Cell-Based Therapy for Type 1 Diabetes

Diabetes, Mesenchymal Stem Cells, Stem Cell Research

Currently, it’s estimated that nearly 1.5 million Americans are living with type 1 diabetes (T1D), a number that is expected to increase to over 2 million by the year 2040[1]. In the U.S. alone, healthcare costs and lost wages directly related to T1D currently exceed $16 billion per year. While the most common treatment…

November 4, 2022

Mesenchymal Stem Cell-Based Therapy For Rheumatoid Arthritis

Mesenchymal Stem Cells, Rheumatoid Arthritis, Stem Cell Research

Mesenchymal stem cells (MSCs) have demonstrated the ability to differentiate into a number of different cells; they also demonstrate immunomodulatory properties that have great potential for use as a stem cell-based therapeutic treatment option and for the treatment of autoimmune diseases - including rheumatoid arthritis (RA). RA is a chronic and debilitating inflammatory disorder that…

October 1, 2022

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Non-Coding RNA Therapeutic Vehicles in Autoimmune Diseases

Exosomes, Extracellular Vesicles, Mesenchymal Stem Cells, Stem Cell Research

The number of people experiencing autoimmune diseases (ADs) continues to increase worldwide. Currently, it's estimated that between 2 and 5% of the global population is afflicted with the most severe forms of these diseases, including type 1 diabetes (T1DM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). An autoimmune disease can occur nearly anywhere in…

August 5, 2022

Using Mesenchymal Stromal Cells For The Treatment of Spinal Cord Injuries

Mesenchymal Stem Cells, Spinal Cord Injury, Stem Cell Research

Spinal cord injury (SCI) continues to be a significant cause of disability. In fact, it is estimated that annual SCIs account for nearly 18,000 injuries in the United States and between 250,000 and 500,000 injuries worldwide[1]. While the main cause of SCIs in the United States continues to be motor vehicle accidents, other contributors include…

July 29, 2022

Using Mesenchymal Stem Cells for Treatment of Immune and Inflammation-mediated Diseases.

Mesenchymal Stem Cells, Stem Cell Research

Stem cells, and specifically mesenchymal stem cells (MSCs), have long been considered as a promising therapeutic agent for the treatment of a wide variety of degenerative and ischemic diseases. Over this time, MSC immunomodulation, their capacity for multilineage differentiation, and their ability to self-renew have been well established and are now considered to be clinically…

July 22, 2022

Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis.

Mesenchymal Stem Cells, Rheumatoid Arthritis, Stem Cell Research

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that causes your immune system to mistakenly attack its own tissue and specifically affects the lining of the joints, resulting in painful swelling, bone erosion, and eventually permanent joint deformity. With an estimated 1.5 million people in the U.S. living with RA, the disease affects nearly…

July 15, 2022

Mesenchymal Regenerative Medicine for Osteoarthritis: The Critical Role of the Cell Secretome

Extracellular Vesicles, Mesenchymal Stem Cells, Osteoarthritis, Stem Cell Research

Osteoarthritis (OA) is the most common form of arthritis, affecting over 525 million people around the world. Characterized by pain, swelling, and stiffness resulting from the degradation of cartilage that provides cushion and protection between our bones, OA is an inflammatory condition without a clear and effective treatment. OA most commonly affects the hands, knees,…

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