Amyotrophic Lateral Sclerosis (ALS) is a degenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle paralysis and death, typically within 3-5 years of onset. Despite two FDA-approved therapies, Riluzole, and Edravarone, which offer limited benefits, there remains no cure for ALS. Considering this, researchers have turned to Mesenchymal stem…
Neurodegenerative diseases, which include conditions like amyotrophic lateral sclerosis (ALS), motor neuron disease, stem cell therapy for Parkinson disease’s disease, and stem cell therapy for multiple sclerosis (MS), are characterized by the progressive loss of structure and function of neurons. These conditions are currently considered incurable and utilize treatments focusing primarily on managing symptoms rather…
According to the World Health Organization, an estimated 422 million people worldwide have diabetes. Numerous studies have demonstrated that people with diabetes are at an increased risk of developing both acute and chronic pancreatitis, which increases the risk of developing pancreatic cancer. Considering the lack of effective therapeutic options for pancreatitis and the limited treatment…
The International Association for the Study of Pain defines neuropathic pain as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system”. While general neuropathy is diverse by nature, neuropathic lesions generally fall into four categories: focal or multifocal lesions of the peripheral system, general lesions of the peripheral nervous…
Neuropathic pain is pain caused as part of a dysfunction in the nervous system, including the peripheral nerves, brain, and spinal cord. Often characterized by spontaneous pain occurring for no specific reason, neuropathic pain can range from mild to severe and is currently estimated to affect 150 million people in the United States. The risk…
Nerve damage resulting from stem cell therapy for spinal cord injury (SCI) often leads to temporary or permanent loss of function and contributes to poor quality of life. Most common among males below 30 years of age, SCI recovery has been limited specifically as a result of the low growth capacity of neurons and a…
Spinal cord injuries (SCI) are the most serious complication associated with spinal injuries and often result in permanent damage to the nervous system. With nearly 300,000 people in the United States living with SCI, the inability to treat these injuries has a significant impact on physical, mental, and financial health. Additionally, while 94% of those…
Chronic skin inflammatory diseases, including atopic dermatitis (AD) and psoriasis, are considered uncontrolled responses to systemic inflammation. Characterized by swelling, irritation, and rash chronic skin inflammatory disease, these common skin inflammatory diseases are estimated to affect 25% of the population, with AD and psoriasis being the most common form of the disease. Recent methods used…
With more than 17,000 people in the US sustaining a spinal cord injury (SCI) each year and an estimated combined cost to healthcare and the workforce exceeding $40 billion, the condition has significant personal and socioeconomic implications. In addition, SCIs have limited pharmacological treatment options to support the regeneration of nerve damage. Considering the limited…
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of upper and lower motor neurons resulting in paralysis, respiratory insufficiency, difficulties speaking and swallowing, stiffness and spasticity, and muscle atrophy. Commonly known as Lou Gehrig’s disease, after the baseball player was diagnosed with it, ALS is diagnosed in an estimated 5,000 Americans…
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