Recent estimates indicate that one in every 10 people is affected by an autoimmune disease. Autoimmune diseases occur when the normal function of the immune system mistakenly attacks normal and healthy cells within the body; examples of autoimmune diseases include rheumatoid arthritis, type 1 diabetes, and lupus. Currently, there are over 80 known types of…
Ankylosing spondylitis (AS) is a progressive, inflammatory rheumatoid disease that, over time, can result in chronic spinal arthritis and can cause the vertebrae to fuse together. Affecting an estimated 300,000 people in the U.S., AS causes the spine to become less flexible and can result in a hunched posture. There is no current treatment for…
Articular cartilage primarily consists of chondrocytes and extracellular matrix and has an essential role in the process of joint movement, including lubrication, shock absorption, and conduction. However, over time, damage to the articular cartilage caused by acute or repetitive trauma or disease of the joints - including osteoarthritis - often results in pain, lack of…
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes inflammation to affect many different body systems including the joints, skin, kidneys, blood cells, brain, heart, and lungs. Affecting over 5 million people worldwide, and associated with a wide range of symptoms, SLE is difficult to diagnose. Currently, there is no treatment to prevent or…
Chronic obstructive pulmonary disease (COPD) is a condition that affects about 12.5 million people in the United States. COPD can become progressively worse over time and affect your breathing. Although lifestyle changes, oxygen therapy, and medications have traditionally served as the standard treatment choices, there is now another promising option for treating COPD, regenerative medicine,…
Biomedical applications of mesenchymal stem cells (MSCs) in the field of regenerative medicine continue to evolve. Coupled with the rapid development of molecular biology and transplantation techniques, MSC applications have become a central focus of research surrounding regenerative medicine. Since being discovered nearly 50 years ago, the understanding of various techniques for MSC extractions and…
Parkinson’s disease is a complex neurological disorder. It can affect many aspects of your life and wear down your mental health. Fortunately, there are now modern treatment options that help you manage your Parkinson’s symptoms. If you’ve just received a Parkinson’s diagnosis, don’t give up hope. Learn more about your treatment options so you can…
Mesenchymal stromal cells (MSCs) have repeatedly demonstrated the capacity to limit injury and promote regeneration through signaling and secretion of trophic factors. Considering this, MSCs have been increasingly used as a treatment for a wide variety of injuries and immune-related, infectious, and degenerative diseases. In this review, Jahromi et al. provide a brief overview of…
Ankylosing spondylitis (AS) is a chronic and progressive inflammatory disease that primarily affects the sacroiliac joints and the spine; in rare cases, AS can also cause issues for the peripheral joints and extra-articular organs, including the skin, eyes, and cardiovascular system. While there are a number of drugs prescribed to treat symptoms associated with AS,…
Mesenchymal stem/stromal cells (MSCs) continue to be viewed as a source of cell therapy applications due to their immunomodulatory and anti-inflammatory effects and because of their ability to stimulate angiogenesis. In MSCs, these benefits are mainly attributed to the secretion of factors. Despite MSCs’ known and favorable proliferation levels, multipotency, and immune response regulation, there…
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