Spinal cord injury (SCI) is a devastating condition that causes severe nerve damage, leading to impaired movement, sensation, and bodily functions. The injury sets off a series of damaging processes, including excessive inflammation, loss of essential nutrients, and scar tissue formation.
These factors prevent the regeneration of nerve cells, making recovery difficult. Traditional treatments provide limited improvement, but recent research by Lui et al. suggests that mesenchymal stem cells (MSCs) offer hope for patients with SCI.
How SCI Disrupts the Microenvironment
Following SCI, the body experiences a host of negative effects. Initially, the injury causes direct damage to nerve cells, leading to inflammation and the release of harmful substances.
The body’s attempt to repair the damage often backfires, as excessive inflammation worsens tissue destruction and inhibits nerve regeneration. Additionally, the blood-spinal cord barrier (BSCB) becomes compromised, allowing immune cells to flood the injured site.
These immune cells produce harmful molecules like reactive oxygen species (ROS) and cytokines, further aggravating the damage.
The prolonged inflammation creates a hostile environment that prevents new nerve growth and leads to the formation of scar tissue that blocks potential regeneration.
The Role of MSCs in Repairing the Spinal Cord
The ability of MSCs to repair spinal cord injuries (SCI) lies in their powerful secretions of bioactive molecules, which help regulate inflammation, promote nerve cell survival, and enhance tissue repair.
MSCs suppress harmful immune responses by decreasing the activity of pro-inflammatory cells like T-cells and macrophages while promoting anti-inflammatory pathways to minimize further nerve damage. They also release neurotrophic factors that nourish and support nerve cells, encouraging the survival and growth of new neurons to improve recovery.
Additionally, MSCs help prevent the formation of dense glial scar tissue, which can obstruct axon regrowth, by regulating proteins like MMP-2 and BDNF that break down scar tissue and create space for new nerve connections. Furthermore, MSCs contribute to angiogenesis, promoting blood vessel growth to ensure that the injured site receives adequate nutrients and oxygen for healing.
Optimizing MSC Therapy for SCI
To ensure MSC therapy is effective for SCI treatment, the authors call for additional research to determine the most efficient timing, dosage, and delivery method.
Timing for MSC Transplantation
Studies suggest that MSCs work best when introduced during the subacute phase (approximately two weeks after injury). This timing allows MSCs to reduce inflammation while the injury is still healing. If administered too early, the highly inflammatory environment may kill MSCs before they can have a therapeutic effect. If given too late, scar tissue may already be well established, limiting their benefits.
Optimal Dosage
According to Liu et. al, research on animals suggests that higher doses of MSCs (greater than one million cells) lead to better functional recovery.
However, an excessively high dose might provoke an unwanted immune response. In humans, doses typically range from 10 to 100 million cells, though further research is needed to determine the optimal amount.
Optimizing MSC Delivery for Spinal Cord Repair
MSCs can be delivered in different ways. Intravenous (IV) injection is the least invasive, but many cells get trapped in organs like the lungs before reaching the spinal cord. Direct injection into the injury site is more targeted but carries risks of additional damage. Intrathecal injection (into the spinal fluid) is a promising middle ground, as it allows MSCs to circulate in the cerebrospinal fluid and reach the injury without additional trauma.
Advancing MSC Therapy for Spinal Cord Injury: Challenges and Future Prospects
Although MSC therapy holds great promise, several challenges remain before it can become a routine treatment for SCI. Researchers need to refine techniques for improving MSC survival, homing (their ability to find the injured site), and integration into the spinal cord. Scientists are also exploring genetic modifications and biomaterial scaffolds to enhance MSC effectiveness. Additionally, large-scale clinical trials are necessary to confirm safety and efficacy in human patients.
In the future, personalized MSC therapy – where treatment is tailored to each patient’s specific injury and biological factors – could revolutionize SCI treatment.
Liu et al. conclude that ongoing advancements in stem cell research, MSC transplantation has the potential to improve the quality of life for SCI patients by restoring lost function and promoting recovery in ways that were once thought impossible.
Source: Liu, Y., Zhao, C., Zhang, R. et al. Progression of mesenchymal stem cell regulation on imbalanced microenvironment after spinal cord injury. Stem Cell Res Ther 15, 343 (2024). https://doi.org/10.1186/s13287-024-03914-x
Neurological diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and ALS (amyotrophic lateral sclerosis) affect millions of people around the world. These conditions often develop slowly and progressively damage the brain and spinal cord, leading to symptoms such as memory loss, difficulty moving, problems with speech, and the inability to perform daily tasks. While current treatments can help manage symptoms and slow progression, they don’t repair the underlying damage to nerve cells.
Neural stem cell therapy is a new approach that may change this. By tapping into the body’s natural ability to grow and repair nerve tissue, researchers hope to develop treatments that can do more than ease symptoms – they may one day restore function and improve quality of life for those living with neurological diseases.
As part of this review, Yang et al. discuss the application and value of NSCs in neurological diseases as well as the existing problems and challenges.
Defining Neural Stem Cells
Neural stem cells, or NSCs, are special types of cells that exist in the brain and spinal cord. They are able to make more of themselves and can also develop into different types of brain cells. These include neurons, which carry signals in the brain; astrocytes, which provide support and nutrients to neurons; and oligodendrocytes, which help protect nerve fibers by forming a coating around them.
In early development, NSCs help build the brain and nervous system. In adults, small numbers of NSCs remain in certain parts of the brain, where they play a limited role in maintaining brain health. However, their natural healing abilities are not enough to repair the kind of widespread damage seen in conditions like Parkinson’s or ALS.
According to the authors, scientists are now learning how to grow these cells in the lab and use them in therapy to help the body heal from neurological disease.
Barriers to Natural Nerve Repair
Unlike other parts of the body, the brain and spinal cord do not heal easily after injury or disease. When neurons die, they are not naturally replaced. This is a major reason why neurological diseases are so difficult to treat. For example, in Parkinson’s disease, dopamine-producing neurons in the brain die off, leading to tremors and difficulty with movement. In ALS, the motor neurons that control muscle movement degenerate, eventually affecting a person’s ability to walk, speak, and breathe.
Most treatments available today focus on easing symptoms or slowing down how quickly the disease progresses, but they are unable to fix the problem at its source. Neural stem cell therapy aims to do just that – repair or replace damaged nerve cells, restore connections, and support the brain’s ability to function normally again.
Mechanisms of Neural Stem Cell-Mediated Healing
Neural stem cells do more than simply turn into new neurons. Research has shown that they can protect existing nerve cells from further damage and promote the growth of axons, which are the long fibers that send messages from one neuron to another. In diseases where nerve fibers lose their protective coating, NSCs may also help rebuild that layer and improve communication between cells.
In addition, these cells release helpful molecules that support brain health, such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). These substances help nourish nerve cells and keep them alive longer. NSCs also seem to help reduce inflammation, which is a common feature in many neurological conditions and can make symptoms worse. By calming the immune system and supporting blood vessel growth, NSCs are able to create a healthier environment for the brain and spinal cord to recover.
Tailoring Therapy to Specific Diseases
Each neurological disease affects a specific set of brain or nerve cells. In Parkinson’s disease, it’s the dopamine-producing neurons in a region of the brain called the substantia nigra. In Alzheimer’s disease, neurons are lost across many parts of the brain, affecting memory and thinking. Huntington’s disease causes damage in the parts of the brain that control movement and emotions. ALS destroys the motor neurons that control voluntary muscles.
Because these diseases target particular cell types, Yang et al. believe neural stem cell therapy offers a tailored approach to treating these diseases. By delivering NSCs directly to affected areas, researchers hope to replace the cells that have been lost, support the survival of remaining neurons, and help rebuild the pathways the brain needs to function. This is different from current treatments, which manage symptoms without addressing the actual damage in the brain or spinal cord.
Findings from Clinical Research
While this field is still developing, the authors point to early clinical trials that have already tested neural stem cell therapy in patients with ALS and Parkinson’s disease. In one study involving 12 ALS patients, stem cells were injected into the spinal cord. The procedure was found to be safe, and some patients experienced a slower progression of their symptoms over the next two and a half years.
Another small study combined NSC therapy with a vaccine aimed at boosting the immune system. In this study, patients with ALS lived longer and showed improvements in function for at least a year. Yet another group of ALS patients received stem cells derived from fetal tissue, and most of them remained stable with no serious side effects for 18 months. A larger follow-up study involving 18 ALS patients also confirmed the safety of the treatment over a five-year period.
For Parkinson’s disease, a recent study transplanted NSCs into the brains of eight patients. Most participants reported better movement and coordination in the months and years that followed. Brain scans also showed signs of increased dopamine activity, which is usually low in people with Parkinson’s.
Although the studies are small, the authors indicate that they suggest that NSC therapy is well tolerated and has the potential to improve quality of life for patients with serious neurological conditions.
Future Outlook for Neural Stem Cell Therapy
Neural stem cell therapy has the potential to change how neurological diseases are treated. Instead of simply managing symptoms, this novel approach aims to repair and rebuild the nervous system. While the science is still evolving, Yang et al. point to early studies in patients with ALS and Parkinson’s disease as evidence that NSC therapy is safe and may lead to real improvements in function and quality of life.
Source: Yang L, Liu SC, Liu YY, Zhu FQ, Xiong MJ, Hu DX, Zhang WJ. Therapeutic role of neural stem cells in neurological diseases. Front Bioeng Biotechnol. 2024 Mar 7;12:1329712. doi: 10.3389/fbioe.2024.1329712. PMID: 38515621; PMCID: PMC10955145.
Multiple sclerosis (MS) is a complex and unpredictable disease that affects the central nervous system, leading to a variety of symptoms. Identifying the early warning signs of multiple sclerosis is very important for seeking prompt treatment and potentially slowing its progression. One of the most promising advancements in MS treatment is stem cell therapy. Stem cell treatments for multiple sclerosis focus on repairing nerve damage, regenerating myelin, and improving overall function. Although still being researched, stem cell therapy for MS has shown promise in reducing symptoms such as muscle weakness, fatigue, and coordination issues. In a clinical trial published in JAMA Neurology, 69% of patients who underwent hematopoietic stem cell transplantation (HSCT) experienced no progression of disability over five years, compared to just 46% in the control group receiving standard disease-modifying therapies (DMTs).
At Stemedix, we specialize in providing advanced stem cell therapies, offering patients personalized care and treatment options. This blog will discuss the potential benefits and limitations of stem cell therapy for MS, helping you determine if it’s the right option for you and how it could enhance your quality of life.
What is Multiple Sclerosis (MS)?
Multiple sclerosis (MS) is a chronic autoimmune condition that affects the central nervous system. It occurs when the immune system mistakenly attacks the myelin sheath, which serves to protect nerve fibers. This damage interferes with communication between the brain and the rest of the body, impacting motor skills, sensory perception, and cognitive functions.
The symptoms of MS can vary widely from one person to another, making early diagnosis difficult. Common early signs of multiple sclerosis include blurred or double vision, unexplained fatigue, and numbness or tingling in the limbs. These symptoms may appear intermittently, which can complicate the identification of the condition in its early stages.
MS can progress differently for each individual. Some people experience flare-ups followed by periods of stability, while others may notice a gradual worsening of symptoms. Identifying early warning signs of multiple sclerosis is important for a timely diagnosis and exploring potential treatments that can help manage symptoms and slow disease progression.
At Stemedix, we recognize the profound impact MS can have on your life. We are dedicated to providing advanced treatment options designed to improve your quality of life. If you are experiencing any of these early warning signs of multiple sclerosis, we encourage you to consult with a healthcare professional and explore treatments that could positively influence your health journey.
What is Stem Cell Therapy for Multiple Sclerosis?
Stem cell therapy for multiple sclerosis (MS) provides a new way to address the challenges of the disease by targeting nerve damage. The main objective of this treatment is to repair the myelin sheath, which safeguards nerve fibers and gets damaged by MS. By repairing this critical tissue, stem cell therapy may help restore lost functions and slow the progression of the disease.
Stem cells are remarkable in their ability to transform into various cell types, including nerve cells. There are two primary types of stem cells used in MS treatment: autologous stem cells, which come from the patient’s own body, and allogeneic stem cells, which are harvested from a healthy donor.
These stem cells are introduced into the patient’s body through a specific process designed to repair the damaged myelin tissue. Additionally, stem cell therapy is believed to help regulate the immune system. Since MS is an autoimmune condition where the immune system attacks the body’s tissues, this function of stem cells is vital in the treatment.
Although stem cell therapy for MS is still considered experimental, it offers the potential for not just repairing nerve damage but also slowing or even stopping the disease’s progression. However, it is important to recognize that it has not yet received approval from regulatory authorities like the FDA.
At Stemedix, we understand the daily challenges of living with MS. Our team is dedicated to offering personalized care to help improve your quality of life and explore potential treatments that may offer a new approach to managing this complex disease.
Potential Benefits of Stem Cell Therapy for MS
Stem cell therapy for multiple sclerosis (MS) offers promising potential for improving the lives of those affected by this chronic condition. While still in the experimental stage, research and clinical studies are showing encouraging results for the benefits this treatment could provide. Below are some of the main advantages stem cell therapy may offer MS patients:
Improvement in Motor Function and Mobility
Stem cell therapy for MS holds great potential in improving motor function and mobility. MS causes nerve damage that interferes with communication between the brain and muscles, leading to issues with coordination, balance, and movement. By repairing the damaged myelin sheath, stem cells can help restore some motor function, resulting in better balance and coordination. This improvement can make it easier for individuals to walk and complete daily activities. Additionally, stem cell treatments may increase the range of motion, offering more independence and reducing the need for assistive devices like canes or walkers.
Reduction in Symptoms of MS
Stem cell therapy has shown potential in helping to manage some of the more challenging symptoms of multiple sclerosis (MS). Symptoms like muscle spasms, numbness, and tingling are often caused by nerve damage. Stem cells may help repair this damage, potentially reducing the severity and frequency of these symptoms. Additionally, stem cell therapy may help alleviate chronic pain and fatigue, which are common in many MS patients, by promoting nerve regeneration. These improvements could make daily activities easier and substantially improve a patient’s overall quality of life.
Slowing Disease Progression
Another benefit of stem cell treatments for multiple sclerosis is its potential to slow or even stop the progression of the disease. A long-term follow-up study found that 44% of patients who received autologous hematopoietic stem cell transplantation (AHSCT) remained free from progression after 10 years, compared to just 16% in those receiving conventional therapies. While stem cell therapy for MS is not a cure, studies indicate they may help prevent further damage to the myelin sheath, which is essential for preventing the neurological decline associated with MS. By stabilizing the condition and limiting additional nerve damage, stem cell therapy could slow the progression of MS, providing long-term benefits. This may allow people with MS to preserve their mobility, cognitive abilities, and overall well-being for a longer time.
Stem cell therapy for MS offers promising potential in enhancing mobility, reducing symptoms, and slowing the progression of the disease. While further research is necessary to determine its long-term impact fully, these possible benefits bring hope to those living with MS. At Stemedix, we focus on providing personalized care and treatment options designed to help manage MS symptoms.
Limitations and Considerations of Stem Cell Therapy for MS
While stem cell therapy for multiple sclerosis (MS) offers potential benefits, it is important to identify the limitations and factors that come with this treatment. Like any medical treatment, stem cell therapy has its challenges. Let’s explore some key considerations that need attention:
Research and FDA Approval Status
While stem cell therapy for MS holds significant promise, it’s important to note that it is still in the experimental stage. Initial research and clinical trials have shown encouraging results, but the treatment has not yet received FDA approval. Since the therapy has not been FDA-approved, there is limited long-term data on its safety and effectiveness. More extensive studies are needed to understand its full potential better. Patients interested in this treatment should be aware that it is still under investigation, and outcomes may vary. However, these early findings suggest a hopeful future for the therapy in managing MS.
Individual Response to Treatment
The results of stem cell treatments for multiple sclerosis can vary for each person. Different factors, such as overall health, the stage of MS, and disease progression, influence how a patient responds to the treatment. For example, people in the early stages of MS may experience greater improvements in mobility and symptom relief than those in later stages. Other factors, like age, immune system function, and existing health conditions, can also affect how effective the therapy is. This is why a thorough evaluation is needed to conclude whether stem cell therapy is the best option for each patient.
Cost and Accessibility
Stem cell treatments for multiple sclerosis may come with costs that can vary depending on the type of treatment and the care needed. These expenses typically include stem cell harvesting, the procedure itself, and any post-treatment care or monitoring. Since stem cell therapy for MS is still considered experimental, many insurance plans may not cover the treatment. However, at Stemedix, we work to make this treatment as accessible as possible. We offer a dedicated care coordinator to help you understand both the potential benefits and costs. Additionally, we provide guidance on financing options so you can feel supported throughout the process. While the financial considerations are important, we are committed to helping you find the best solution for your needs.
Stem cell therapy for MS offers promising potential, but it’s important to consider its limitations. At Stemedix, we focus on providing personalized consultations to help patients navigate the decision-making process. We assist in evaluating the benefits and drawbacks of stem cell therapy based on each patient’s individual needs.
The Stemedix Approach to Stem Cell Therapy for MS
At Stemedix, based in Saint Petersburg, FL, we recognize that multiple sclerosis (MS) is a complex condition that affects each person in unique ways. This is why we prioritize personalized care to help MS patients achieve the best possible results from stem cell therapy. Our approach is tailored specifically to each patient’s needs, ensuring that every aspect of the treatment process aligns with their individual health goals and circumstances. Below, we’ll explain how Stemedix provides specialized care for MS patients through stem cell therapy.
Personalized Treatment Plans
At Stemedix, we understand that every patient’s experience with MS is unique. That’s why we prioritize personalized treatment plans tailored to your condition, medical history, and treatment goals. During your initial consultation, we gather important information about your MS progression, symptoms, and other relevant health factors. This helps us design a treatment plan that directly addresses your needs, increasing the likelihood of a successful outcome. Whether your goal is to improve mobility, reduce symptoms such as numbness, or slow disease progression, we collaborate with you to create a plan that best supports your journey.
How Stemedix Supports Patients Through Their Journey
Stem cell therapy for MS can be a complex process, and it may feel overwhelming for some patients. At Stemedix, we are dedicated to guiding you through each step of the treatment. Our team provides thorough logistical support to help you access the care you need. If you’re traveling from out of town, we assist with travel arrangements, accommodations, and other services, making your visit as seamless and stress-free as possible. We want you to focus on your health and treatment, not on the logistics of your journey.
Beyond logistical support, our experienced care coordinators are always available to assist you throughout the therapy process. They can answer your questions, offer updates on your treatment progress, and address any concerns that arise during your recovery. This level of personalized care helps you feel informed, supported, and confident as you move forward with your stem cell therapy for MS.
At Stemedix, we focus on providing patient-centered care, combining advanced stem cell treatments with compassionate support. Our tailored treatment plans and dedicated assistance are designed to help improve your quality of life while managing the symptoms and progression of multiple sclerosis.
Stemedix: A New Path to Managing Multiple Sclerosis
Stem cell therapy for multiple sclerosis (MS) presents a promising approach for managing symptoms and potentially slowing disease progression. While it is not a cure, early research suggests that this therapy could greatly improve the quality of life for those with MS. The goal of stem cell treatments is to repair nerve damage and help regulate the immune system, providing relief from symptoms such as muscle weakness, fatigue, and cognitive issues. It may also offer hope for those noticing early warning signs of multiple sclerosis, helping to slow the progression of the disease.
If you’re considering stem cell therapy for MS, it’s essential to consult with a healthcare provider to determine if it’s the right treatment for you. At Stemedix, we provide personalized consultations and tailored treatment plans that focus on your unique needs, ensuring you receive the best care possible.
To learn more about your treatment options and understand how stem cell therapy can help you manage MS, contact us at (727) 456-8968 or email at yourjourney@stemedix.com. Our team is here to support you every step of the way on your path to better health.
Spinal cord injury (SCI) can lead to lasting health challenges, impacting motor, sensory, and autonomic functions. Recovery from such injuries is particularly difficult due to the central nervous system’s limited ability to repair itself. As a result, scientists have turned to stem cell therapies, particularly mesenchymal stem cells (MSCs), as a potential solution to help treat traumatic spinal cord injuries (TSCI).
In this review, Montoto-Meijide et al. explore the role of stem cell therapy in TSCI treatment, the safety and efficacy of MSCs, and the ongoing research aimed at improving these therapies.
Spinal Cord Injury and the Need for Effective Treatments
A spinal cord injury results from trauma that damages the spinal cord, leading to various degrees of paralysis and loss of sensory functions. Recovery is limited because the central nervous system does not regenerate easily, meaning that cells, myelin (which insulates nerve fibers), and neural connections are difficult to restore. Traditional treatments focus on alleviating symptoms and preventing further injury, but they do not offer a cure or promote regeneration. As a result, researchers are exploring stem cell therapies, which have shown potential in regenerating damaged tissues and promoting recovery.
An Overview of Mesenchymal Stem Cells (MSCs)
Stem cells are unique in that they can self-renew and differentiate into different types of cells. MSCs are a type of adult stem cell that can develop into various cell types, including bone, cartilage, muscle, and fat cells. MSCs are particularly promising in SCI treatment because of their ability to regenerate tissues and support healing. These cells have shown anti-inflammatory, anti-apoptotic (preventing cell death), and angiogenic (promoting new blood vessel growth) properties, all of which could aid in the healing of spinal cord injuries.
There are different types of stem cells, including embryonic and adult stem cells. Each source has its advantages and drawbacks. Bone marrow MSCs are the most commonly used in research and clinical trials, but adipose tissue and umbilical cord MSCs are gaining attention due to their availability and regenerative capabilities.
The Role of MSCs in Treating Spinal Cord Injuries
MSCs offer several benefits when applied to SCI treatment. They can promote tissue repair, reduce inflammation, and enhance the formation of new blood vessels. When introduced into an injured spinal cord, MSCs have been shown to:
Promote axonal (nerve fiber) regeneration
Reduce inflammation around the injury site
Support the survival of nerve cells
Enhance the formation of new blood vessels, aiding in tissue repair
These capabilities make MSCs an exciting avenue for research into TSCI treatment. Clinical trials and studies have shown that MSCs can lead to improvements in motor and sensory functions, although the extent of these improvements varies.
Clinical Evidence and Findings
A systematic review of clinical studies involving MSCs for TSCI was conducted, analyzing data from 22 studies, including 21 clinical trials. According to the authors, these findings suggest that MSC-based therapies can lead to improvements in sensory and motor functions, although these effects are often more pronounced in sensory functions than motor functions. Improvements in patients’ ASIA (American Spinal Injury Association) impairment scale grades have been reported, indicating positive outcomes for many individuals.
The safety of MSC therapies was also a key focus of these studies. Overall, MSC-based treatments were found to have a good safety profile, with no significant adverse effects such as death or tumor formation reported in clinical trials. Some studies did report mild side effects, such as temporary inflammation or mild discomfort, but these were generally short-lived and not severe.
The Future of MSC Therapy and Other Potential Treatments
MSC therapy represents one of the most promising areas of research for TSCI, but it is not the only potential treatment. Other therapies, including gene therapies, neurostimulation techniques, and tissue engineering approaches, are also being explored to address the challenges of spinal cord injury. The authors believe these approaches could complement MSC therapies or offer new avenues for healing and recovery.
For MSC therapy to become a standard treatment for TSCI, additional research is needed. Clinical trials with larger patient groups, longer follow-up periods, and standardized protocols will be necessary to better understand how MSCs can be used most effectively in treating spinal cord injuries. Additionally, researchers are exploring the best stem cell sources, optimal timing for treatment, and the ideal dosage to maximize benefits.
A Promising Future for Spinal Cord Injury Treatment
While spinal cord injuries are currently devastating and challenging to treat, stem cell therapy, particularly with MSCs, offers a hopeful future. Early studies suggest that MSCs can help promote tissue repair, reduce inflammation, and improve motor and sensory functions, although further research is needed to confirm these findings and explore long-term effects. The scientific community continues to make strides in understanding how MSCs and other therapies can help people with TSCI recover and regain functionality, offering hope for the future.
Source: Montoto-Meijide R, Meijide-Faílde R, Díaz-Prado SM, Montoto-Marqués A. Mesenchymal Stem Cell Therapy in Traumatic Spinal Cord Injury: A Systematic Review. Int J Mol Sci. 2023 Jul 20;24(14):11719. doi: 10.3390/ijms241411719. PMID: 37511478; PMCID: PMC10380897.
Metabolic syndrome (MS) is a group of conditions that occur together, raising the risk for cardiovascular disease (CVD) in men and women and is associated with a number of diseases including sleep apnea, liver disease, polycystic ovary syndrome (PCOS), and hormone-sensitive cancers.
The prevalence of metabolic syndrome varies by region and population, but it is estimated to affect around 20-25% of the global adult population. Currently, it’s estimated that approximately 1 billion people worldwide may have metabolic syndrome.
Additionally, sex hormones play a critical role in sex differences and cardiovascular disease risk associated with MS. However, the relationship between sex hormone rations and metabolic and inflammatory markers are unclear according to sex and age differences.
As part of this study, Dubey et al. evaluated the associations of sex hormone ratios with MS and inflammation among males and females.
Currently CVD accounts for 33%-40% of all mortality in the United States and European Union. Men are more likely to be at risk for CVD than women, however the risk of women developing CVD increases drastically after menopause.
According to the authors, this study found that the Free Estradiol Index (FEI) is a more reliable indicator of metabolic syndrome (MS) and high C-reactive protein (CRP) levels than other hormone indexes in men across all age groups. For women over the age of 50, FEI is also strongly associated with these conditions. However, in women under 50, the Free Androgen Index (FAI) is more closely linked to MS and high CRP levels.
Based on these findings, Dubey et al. recommend that doctors regularly check these hormone ratios to identify individuals at risk for cardiovascular disease (CVD) and to manage MS and inflammation early.
In men, FEI emerged as the strongest predictor of MS and high CRP levels, regardless of age. This finding aligned with the limited existing research primarily focusing on older men. The authors point out that this study is among the first to demonstrate this association in younger men. For women aged 50 and older, a high FEI was consistently linked to adverse metabolic and inflammatory profiles. Emerging studies continue to support these findings and suggest that managing FEI levels could help reduce the risk of MS and related inflammatory conditions in older women.
For younger women under 50, FAI was identified as the most critical factor associated with MS and high CRP. The study’s findings in this area supports other research indicating that higher androgen levels are a common feature in women with MS before menopause.
In both men and women, low levels of Sex Hormone-Binding Globulin (SHBG) were linked to higher rates of MS and CRP, indicating that SHBG is an important marker of metabolic health across all ages and sexes.
The results of this study suggest that regular evaluation of sex hormone ratios, particularly FEI and FAI, is crucial for assessing and managing the risk of MS and inflammation. The authors point out that this approach could help doctors identify individuals at risk for CVD and develop early intervention strategies. However, it is important to note that Dubey et al’s study design does not allow for the establishment of a cause-and-effect relationship. Additionally, hormone levels were measured only once, which may not accurately reflect long-term exposure.
The authors conclude the findings of this study highlight the importance of monitoring sex hormone ratios to better understand and manage metabolic and inflammatory conditions. The authors also call for additional research, especially long-term studies, to confirm these findings and to further explore the role of these hormone ratios in different age groups and sexes.
Source: Dubey P, Singh V, Venishetty N, Trivedi M, Reddy SY, Lakshmanaswamy R, Dwivedi AK. Associations of sex hormone ratios with metabolic syndrome and inflammation in US adult men and women. Front Endocrinol (Lausanne). 2024 Apr 10;15:1384603. doi: 10.3389/fendo.2024.1384603. PMID: 38660513; PMCID: PMC11039964.
Osteonecrosis of the femoral head (ONFH) is a serious condition that affects the hip joint, leading to bone damage and joint problems. The disease occurs when the blood supply to the femoral head (the top part of the thigh bone) is disrupted, leading to small fractures and a failure of the bone to repair itself.
ONFH is a significant health issue worldwide. In the United States, approximately 20,000 to 30,000 people are diagnosed with ONFH each year. In China, more than 8 million individuals over the age of 15 suffer from nontraumatic ONFH annually. This condition mainly affects younger and middle-aged adults, making long-term treatment outcomes particularly challenging.
One of the most common treatment options for severe ONFH is total hip arthroplasty (THA), also known as hip replacement. However, THA has limitations, including a high revision rate and a limited lifespan for the artificial joint.
To preserve the natural joint and delay or avoid surgery, early intervention is essential. Several treatments are currently available, including medication, physical therapy, and surgical procedures like core decompression and bone grafting. However, these methods produce inconsistent results, meaning that better treatment options are still needed.
One promising approach involves mesenchymal stem cell (MSC) therapy. MSCs play an important role in bone healing, and their use in treating ONFH has been studied extensively.
In this study, Zhao et al. explore the available evidence for the therapeutic effect of human umbilical cord mesenchymal stem cells (HUCMSCs) on early-stage traumatic ONFH.
Potential of Stem Cell Therapy in ONFH Treatment
ONFH leads to bone cell death due to lack of blood supply. In patients with ONFH caused by excessive alcohol consumption or steroid use, the ability of MSCs to form new bone is significantly reduced. This results in an imbalance between bone formation and bone loss, leading to the weakening and collapse of the femoral head.
The authors report that adding new MSCs from an external source, such as HUCMSCs, may help by replenishing lost cells and stimulating bone regeneration. Studies have shown that MSCs from healthy individuals can be transplanted into patients without causing immune rejection. MSCs have already been used successfully in regenerating various types of tissues, and they can be obtained from several sources, including bone marrow, fat tissue, and umbilical cords.
BMMSCs are the most commonly studied type of MSCs, but their use is limited because they become less effective with age and disease. Research comparing the effectiveness of different stem cell sources has found that HUCMSCs may be a better alternative. These cells are easily obtained from umbilical cords, involve no ethical concerns, and have strong growth potential. Because of these advantages, HUCMSCs have been proposed as a promising treatment for ONFH.
Safety of Stem Cell Therapy
The authors cite several studies that have analyzed the safety of transplanting both BMMSCs and HUCMSCs. For example, one study following patients for 12 months after receiving MSC therapy found no serious adverse effects. Another study tracked patients for three years and reported no significant side effects.
HUCMSCs, in particular, have been found to improve the local healing environment by secreting factors that reduce inflammation and promote tissue repair. Experimental studies in animals also confirm the safety of HUCMSCs, showing no immune rejection or tumor formation after transplantation.
Effectiveness of HUCMSCs in Treating ONFH
To maximize the effectiveness of HUCMSC therapy, the authors focused on optimizing how the cells are delivered to the femoral head. Intravenous (IV) injection of MSCs demonstrated some benefits, but the number of stem cells that actually reach the affected area was limited. To improve results, researchers also tested direct injection of HUCMSCs into the femoral head, ensuring a higher concentration of cells in the damaged area.
Studies have shown that injected HUCMSCs can survive and function in the low-oxygen and damaged environment of the femoral head. At four weeks after transplantation, a significant number of HUCMSCs were detected in the bone, but by eight weeks, their numbers had decreased. According to the authors, this suggests that the transplanted cells either died or migrated to other areas over time. Despite this, the therapeutic effects at four weeks were better compared to untreated ONFH cases. Imaging studies and tissue analysis confirmed that bones treated with HUCMSCs had improved structure and reduced damage compared to those that did not receive treatment.
Clinical Implications and Future Research
According to Zhao et al., current guidelines suggest that for patients with early-stage ONFH, a combination of core decompression and MSC therapy may be beneficial. Research has shown that MSCs work best when provided in a low-oxygen environment, which enhances their ability to regenerate bone. Further studies are needed to refine MSC treatment strategies, determine the best dosage, and evaluate long-term outcomes.
Future research should also explore ways to prolong the survival of transplanted MSCs in the femoral head. One potential approach is preconditioning MSCs with low oxygen before transplantation to enhance their ability to function in damaged tissue. Other studies suggest that combining MSC therapy with additional bone-supporting treatments, such as growth factors or specialized scaffolds, may improve outcomes.
Stem Cell Therapy for ONFH: A Promising Approach
The authors conclude that HUCMSC therapy offers a promising new approach to treating ONFH by replenishing damaged bone cells, improving blood supply, and reducing inflammation. Compared to other types of stem cells, HUCMSCs have advantages such as easy availability, strong regenerative potential, and low risk of immune rejection. While safety concerns remain, current studies indicate that HUCMSCs are well tolerated and do not cause severe side effects.
Despite this promising approach, ongoing research will help refine the use of HUCMSCs for ONFH treatment and determine the most effective ways to enhance their therapeutic potential. With further development, HUCMSC therapy may become a standard option for preserving hip joint function and delaying or preventing the need for hip replacement surgery.
Source: Zhao J, Meng H, Liao S, Su Y, Guo L, Wang A, Xu W, Zhou H, Peng J. Therapeutic effect of human umbilical cord mesenchymal stem cells in early traumatic osteonecrosis of the femoral head. J Orthop Translat. 2022 Oct 14;37:126-142. doi: 10.1016/j.jot.2022.09.008. PMID: 36313533; PMCID: PMC9582590.
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