Exosomes
Clinical Evaluation of Exosomes for Treating Low Back Pain: A Comprehensive Review
Low back pain is a widespread issue that affects millions of people worldwide, significantly impacting their daily lives and placing a substantial financial strain on the healthcare system. Existing treatment options for low back pain often provide only temporary relief and come with various limitations. With the increasing interest in regenerative medicine, newer treatments like…
Exploring the Therapeutic Potential of Stem Cell-Derived Exosomes in Respiratory Diseases: A Pathway for Pulmonary Delivery
Respiratory diseases are a major global health concern, responsible for millions of deaths each year. Conditions like chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), pulmonary fibrosis, and pneumonia claim many lives annually, and despite advancements in medical research, there is still no cure for many of these diseases. Current treatments typically focus…
The Anti-Inflammatory Effects of Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes on Osteoarthritis Chondrocytes
Osteoarthritis (OA) is the most common form of arthritis and is estimated to affect nearly 365 million people worldwide. Characterized as an inflammatory disease, OA slowly progresses over time and results in the gradual loss of the protective cartilage found on the ends of the bones. While the specific cause of OA has yet to…
Advancements in Exosomes and Their Prospective Application in Ocular Disease
According to the World Health Organization, at least 2.2 billion people worldwide have near or distant vision impairment. In at least 1 billion of these cases, vision impairment could have been prevented or has yet to be addressed. Glaucoma, corneal disease, and retinal disorders are among the leading contributors to these vision impairments. Since the…
Exosomes Derived from Mature Chondrocytes Facilitate Subcutaneous Stable Ectopic Chondrogenesis of Cartilage Progenitor Cells
Repairing the structure and functionality associated with subcutaneous cartilage defects continues to be a challenge in the fields of plastic and reconstructive surgery. While current methods, including autologous chondrocyte implantation and matrix-assisted chondrocyte implantation, have been successful in some regard, they continue to present a number of limitations, including donor limitation, donor morbidity, and degradation…
Harnessing Exosomes as Cutting-Edge Drug Delivery Systems for Revolutionary Osteoarthritis Therapy
Osteoarthritis (OA) is a chronic joint condition that causes pain and lack of mobility through the progressive degradation of joint cartilage. While there are several current pharmaceutical, physical therapy, and surgical treatments to address the symptoms of OA, researchers are interested in developing new therapeutic treatment approaches to address the relentless progression of the condition.…
Mesenchymal Stem Cells and MSCs-Derived Extracellular Vesicles Immunomodulatory Effects in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a common multisystemic autoimmune disease that often results in multi-organ damage when left untreated. Currently affecting over 1.5 million Americans, the etiology and pathogenesis of SLE continue to remain unclear. At present, glucocorticoids and immunosuppressants are the most prescribed course of therapeutic treatment and mostly as a way to manage…
A New Therapeutic Strategy for Cardiovascular Diseases Utilizing Exosomes
Cardiovascular diseases continue to be the leading cause of death globally, accounting for nearly 18 million deaths each year with heart attack and stroke accounting for 80% of deaths. Recently, stem-cell-based therapy has demonstrated the potential to regenerate damaged myocardium and to treat a wide range of cardiovascular diseases (CVDs). Specifically, the ability of mesenchymal…
Mesenchymal Stem Cell-Derived Extracellular Vesicles as Non-Coding RNA Therapeutic Vehicles in Autoimmune Diseases
The number of people experiencing autoimmune diseases (ADs) continues to increase worldwide. Currently, it's estimated that between 2 and 5% of the global population is afflicted with the most severe forms of these diseases, including type 1 diabetes (T1DM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). An autoimmune disease can occur nearly anywhere in…
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