Studying the Potential of Human Stem Cells for Treating Glaucoma

Studying the Potential of Human Stem Cells for Treating Glaucoma

Glaucoma is a group of eye conditions that damage the optic nerve and lead to progressive, irreversible loss of vision. With over 80 million people affected by the condition, glaucoma is the second-leading cause of blindness, behind only age-related macular degeneration.

Although there are several different risk factors, the most understood and treatable risk factor for glaucoma involves controlling the eye’s intraocular pressure, or IOP. When left unaddressed, glaucoma progressively leads to vision loss resulting from damage to axons and associated retinal ganglion cells (RGCs) responsible for transmitting visual information from the eye to the brain. While current treatments for glaucoma are primarily pharmacologic, laser-based, and surgical procedures designed to lower and/or control IOP, they are unable to reverse or restore vision lost as a result of previous damage to the affected axons, RGCs, and the collective optic nerve.

Chanling, Slush, and Zack’s article aim to assess current literature and developments exploring the potential of using human stem cells to further study, and potentially treat, glaucoma and other conditions affecting the optic nerve. For the purposes of this review, the authors divide their discussion into four key areas: stem cell-derived trabecular meshwork cells to control IOP; stem cells as a source of RGCs; stem cell-derived RGCs for transplantation and vision restoration; and stem cells as a source for neurotrophic factors.

Stem Cell-Derived Trabecular Meshwork Cells to Control IOP

Insufficient drainage of the eye’s aqueous humor results in increasing IOP. Current medication for the treatment of this condition reduces aqueous production and or increases aqueous outflow through the trabecular meshwork (TM). Since the TM is a known source of stem cells, researchers hypothesize that these cells and specifically mesenchymal stem cells (MSCs) could be used to repair IOP function and potentially restore vision lost as a result of this condition. 

Recent studies have shown promising results, leading researchers to believe that there is a strong possibility of using stem cell-derived TM cells to preserve optic nerve function and reduce IOP.

Stem cells as a Source of RCGs

In addition to assisting with regulating IOP, researchers believe that stem cells may also be able to preserve, and even restore, RCG function – which is ultimately responsible for vision loss caused by glaucoma.

Specifically, the authors point to a number of animal studies that have demonstrated positive responses in a number of signaling pathways and neuroprotective compounds responsible for promoting RNC function and survival. The authors also point out that, while these studies are promising, none have made it to the clinic.

Stem Cell-Derived RGCs for Transplantation and Vision Restoration

While still a relatively new concept, there has been tremendous progress made in the ability to transplant RCEs and photoreceptor cells in the eye. Coupled with the observed differentiation of RGCs, researchers believe the ability to successfully transplant RGCs, with the intent of restoring glaucoma-related vision loss, is not far off. 

The authors note that, while these findings are promising, there is still much work and additional research to be completed in this area and that the process of transplanting RCGs is much more complicated than the process used for transplanting retinal pigment epithelial cells (RPEs) and photoreceptors cells.

Stem Cells as a Source for Neurotrophic Factors (NTFs)

Research suggests that deprivation of the NTF required for maintenance and survival of neurons is a leading factor in the progression of glaucoma. As a result, additional research has reported that supplementing additional BDNF and other NTFs, through the use of stem cells appears to support the health and survival of RGC. The authors point out that, while promising, the process required during this procedure is challenging, primarily because it requires the blood-retinal barrier to be circumvented.

The authors of this review conclude that, as a result of the rapidly advancing pace of ocular stem cell research and related ongoing advancements in stem cell technology, there are ongoing opportunities to better understand and improve upon the current glaucoma-related biology and to develop pharmacological models that include cell-based therapies in the effort to restore vision to those affected by glaucoma.

Source: (n.d.). The Potential of Human Stem Cells for the Study and … – IOVS  from https://iovs.arvojournals.org/article.aspx?articleid=2518375

Considering the Therapeutic Treatment Potential of Mesenchymal Stem Cells in the Treatment of Glaucoma

Considering the Therapeutic Treatment Potential of Mesenchymal Stem Cells in the Treatment of Glaucoma

Glaucoma is a complex group of interrelated eye conditions that affects over 70 million people worldwide.  A leading cause of irreversible blindness in people over 60, glaucoma is a progressive condition that affects the optic nerve and leads to gradual loss of specific neurons that relay visual information from the retina to the brain; the progressive vision loss caused by glaucoma is often associated with increased pressure in the eyes[1].

Currently, pharmaceutical and surgical treatment for glaucoma focus on relieving pressure in the eye by treating the trabecular meshwork (TM), the part of the eye that relieves pressure by allowing drainage of the aqueous humor. Unfortunately, to date, these treatment options have demonstrated only to delay, not correct, or prevent, the progression of glaucoma. Additionally, these treatment options are not effective in repopulating or regenerating the retinal ganglion cells (RGCs), the neurons that relay visual information to the brain; in other words, these treatments have proven largely ineffective in patients with advanced stages of glaucoma.

With the advances made in stem cell therapy, and especially considering the functional properties of mesenchymal stem cells (MSCs), several new therapeutic approaches to treating glaucoma-related issues are currently being considered.

In this review article, Harrell et. al drew key observations from the information presented in over 250 journal articles to assess the current knowledge and future perspectives when considering the beneficial effects of MSCs in the treatment of glaucoma.

Specifically, researchers have found that the neurotrophins produced by MSCs encourage both the survival and regeneration of RGCs affected by glaucoma; MSCs appear to support RGCs by generating cells that are similar to RGCs and through promoting the expansion and differentiation of retinal stem cells (RSCs) in RGCs. MSCs are also believed to support the integrity of TM cells, allowing for pressure in the eyes to be reduced.

After reviewing the abstracts of 253 journal articles on the topic, the authors of this review concluded that the large number of studies examining MSCs’ ability to treat and/or protect the eye from the harmful effects of glaucoma was primarily dependent on MSCs capacity to provide neuroprotection for, and support regeneration in, RGCs.

However, as the authors point out, while several of these studies appear to demonstrate the potential benefits of MSCs and their secretome in glaucoma therapy, neither the safety nor efficacy have been validated in clinical settings or clinical trials with the appropriate number of enrolled patients. 

While there appear to be several beneficial effects associated with using MSCs and their secretome in glaucoma therapy in humans, the authors conclude that these claims can only be verified if MSC-dependent therapeutic effects are confirmed through future clinical trials.

Source:  (n.d.). Therapeutic Potential of Mesenchymal Stem Cells and … – Hindawi from https://www.hindawi.com/journals/sci/2019/7869130/


[1] “Glaucoma – Symptoms and causes – Mayo Clinic.” 23 Oct. 2020, https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839.

WordPress Image Lightbox
Subscribe To Our Newsletter

Subscribe To Our Newsletter

Join our mailing list to receive the latest news and updates from our team.

You have Successfully Subscribed!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!