Osteoarthritis (OA) continues to be the most common form of degenerative joint disease in the United States and around the world.
According to the World Health Organization (WHO), 528 million people worldwide were living with osteoarthritis (OA) in 2019, which is an increase of 113% since 1990. The Global Burden of Disease Study 2021 found that 595 million people had OA in 2020, which is 7.6% of the global population. The Centers for Disease Control and Prevention (CDC) estimates that over 32.5 million adults in the U.S. currently live with OA.
Despite the tremendous increase in the global incidence of OA, there are no effective pharmaceutical therapies that are able to restore the original structure and function of damaged articular cartilage.
Considering this, cell-based therapies for OA and other orthopedic disorders have become a primary area of current research and development.
In this review, Mobasheri et al. focus on the structure and function of articular cartilage, the pathogenesis of OA, and explore the challenges associated with cartilage repair and regeneration using cell-based therapies that utilize chondrocytes and mesenchymal stem cells (MSCs).
Articular cartilage (AC) has demonstrated a very poor ability to repair and regenerate. Being largely avascular and containing no blood vessels, AC lacks the blood flow required in the biological repair response process.
Overtime, and with age, cartilage loses its already limited capacity for repair and damaged cartilage is typically replaced by fibrocartilage-like scar tissue. With no successful surgical technique demonstrating success in stimulating AC repair and regeneration, autologous chondrocyte implantation (ACI) has emerged as one of the most widely used cell-based repair strategies for articular cartilage. Performed on over 12,000 patients worldwide, ACI has encouraged the growth of durable cartilage-like tissue and demonstrated the ability to significantly reduce pain in patients.
Recent studies have also demonstrated that the immunomodulatory properties of MSCs are able to be exploited for the treatment of many inflammatory and rheumatic conditions, including OA. Specifically, the ability of MSCs to migrate to the site of an injury, induce peripheral tolerance, and inhibit the release of pro-inflammatory cytokines has been observed to promote tissue repair and the survival of damaged cells.
Considering these advances, Mobasheri et al. report that tissue engineering with chondrocytes and MSCs is now considered to be a promising way of repairing articular cartilage lesions. While there is significant evidence of the potential of these cell-based therapeutic treatment options, the authors also point out fundamental weaknesses associated with the models available to date.
Included among these weaknesses is the fact that none of the engineered tissue currently available possess the normal zonal organization of chondrocytes observed in vitro and considered to be the prerequisite for normal cartilage function and for the success of any future clinical application.
While there are still weaknesses associated with tissue utilizing engineering and cell-based therapies to repair cartilage in OA and other orthopedic conditions that require further research, the authors conclude that these emerging therapeutic options hold tremendous promise for managing OA in the future.
Source: Ali Mobasheri, Gauthaman Kalamegam, Giuseppe Musumeci, Mark E. Batt,
Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions, Maturitas,Volume 78, Issue 3, 2014, Pages 188-198, ISSN 0378-5122.
Osteoarthritis (OA) is a prevalent and disabling joint condition that imposes significant health and economic burdens globally. Between 2006 and 2016, the global percentage change in years lived with disability due to OA increased by 31.5%. Knee osteoarthritis (KOA) is the most common form, primarily affecting older adults and those who are obese. Symptoms of KOA include pain, swelling, stiffness, and decreased mobility. KOA’s development involves more than just mechanical wear and tear. It is influenced by genetic and environmental factors, leading to the breakdown of articular cartilage, inflammation, and changes in the underlying bone.
Pathogenesis of KOA
The deterioration in KOA is complex. It begins with mechanical stress and progresses through a cascade of biological processes. Key players in cartilage maintenance are chondrocytes and the extracellular matrix (ECM). Chondrocytes, although only 2% of cartilage volume, are crucial and respond to inflammatory signals that disrupt the balance between ECM production and degradation, limiting cartilage regeneration.
Traditional treatments for KOA are primarily focused on pain management and symptomatic relief, with limited success in regenerating damaged cartilage.
Emerging Cell-Based Therapies For KOA
Mesenchymal Stromal Cells (MSCs) and Exosomes
Recent advances in cell-based therapy for KOA involve mesenchymal stromal cells (MSCs) and their secreted exosomes. MSCs are multipotent cells found in various tissues, including bone marrow, adipose tissue, and synovial fluid. They have the ability to differentiate into multiple cell types, including chondrocytes, and secrete exosomes that carry bioactive molecules.
MSC Selection and Preparation
MSCs can be derived from different sources, including bone marrow, adipose tissue, and umbilical cord tissue. Each source has unique properties and benefits. For instance, bone marrow-derived MSCs (BM-MSCs) are commonly used due to their extensive research background, while adipose tissue-derived MSCs (AT-MSCs) also show promising results.
Exosomes, extracellular vesicles released by MSCs, play a vital role in cell communication. They transfer lipids, nucleic acids, and proteins that can modulate cell behavior and promote cartilage repair.
Mechanisms of MSC-Based Therapy
Effects on Chondrocytes
MSC therapy promotes chondrocyte health by increasing chondrogenesis, improving cell proliferation, reducing apoptosis, and maintaining autophagy. MSCs stimulate chondrocyte activity through growth factors, enhancing their ability to regenerate cartilage. Studies show that MSCs and their exosomes can improve chondrocyte proliferation and reduce apoptosis, helping maintain cartilage integrity.
Impact on the ECM
Regulating the ECM’s balance between synthesis and breakdown is crucial for treating KOA. MSCs influence this balance by modulating matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of MMPs (TIMPs). For example, BM-MSCs can adjust the ratio of MMP-13 to TIMP-1, improving cartilage matrix composition.
Influence on Inflammation
Inflammation is a significant factor in KOA. MSCs and their exosomes can reduce pro-inflammatory cytokines (e.g., IL-1β, TNF-α) and enhance anti-inflammatory responses. This reduction in inflammation helps alleviate cartilage damage and improve joint function.
Immunomodulation
MSCs can modulate immune responses by influencing macrophage polarization. They can shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) state, which helps reduce inflammation and promote tissue repair.
Mitochondrial Function
MSCs can also enhance mitochondrial function in chondrocytes. Mitochondrial transfer from MSCs to chondrocytes improves their energy production and reduces oxidative stress, which is crucial for maintaining cell function and delaying the progression of OA.
Paracrine Effects
The paracrine effects of MSCs, particularly through exosomes, involve the transfer of molecular signals to nearby cells. This signaling can promote cartilage repair and modulate inflammation and cell survival.
Overcoming Obstacles and Refining MSC Therapies for Better Outcomes
While MSC-based therapies show promise, there is a lack of standardized protocols for cell selection and preparation. Additionally, the exact mechanisms through which MSCs and exosomes exert their effects are still being studied. Xiang et al. call for further research to establish standardized methods and fully understand how these therapies work.
External physical conditions, such as hypoxia and magnetic fields, can affect MSC behavior and cartilage regeneration. Hypoxic conditions have been shown to enhance chondrogenesis, while magnetic fields can boost MSC differentiation and cartilage repair. Understanding these effects can improve treatment strategies.
Promising Advances in Cell-Based Therapies for Osteoarthritis Management
Osteoarthritis, particularly knee osteoarthritis, represents a major challenge due to its complex pathogenesis and significant impact on quality of life. Traditional treatments offer limited solutions for cartilage regeneration. However, advances in cell-based therapies, including MSCs and their exosomes, provide promising alternatives. These therapies work through various mechanisms, including enhancing chondrocyte function, modulating inflammation, and improving ECM balance. The authors conclude that ongoing research and standardization efforts will be crucial in optimizing these treatments and addressing the unmet needs in osteoarthritis management.
Source: Xiang, XN., Zhu, SY., He, HC. et al. Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis. Stem Cell Res Ther 13, 14 (2022). https://doi.org/10.1186/s13287-021-02689-9
Primarily a result of its avascular structure and the relatively low metabolic activities of chondrocytes, cartilage has demonstrated a very limited ability to self-repair.
Currently, the primary interventions for cartilage-related injuries only postpone further cartilage deterioration and fail to fully restore or repair cartilage. The limited success of current clinical treatment options for cartilage-related injuries has led to the development of several regenerative medical therapies, including using mesenchymal stem cells (MSCs) as a new strategy in the treatment of cartilage injuries.
Specifically, MSCs have been found to be isolated from mesenchymal tissue and be differentiated into chondrocytes with the support of chondrogenic factors or scaffolds to repair damaged cartilage tissue.
As part of this review, Le et al. highlight the successful repair of cartilage using MSCs or MSCs in combination with chondrogenic factors and/or scaffolds. The authors also provide a detailed presentation of the outcomes of different MSC-based strategies for cartilage regeneration and discuss their prospective translation to use in clinical practice.
Additionally, the authors discuss a number of specific MSC or MSC-combination factors that have shown potential for positive cartilage regeneration outcomes.
The use of MSC alone demonstrated the potential to possibly delay future cartilage degeneration and has been successful in relieving pain and improving joint function in patients with OA and RA. While the implantation of MSCs alone failed to regenerate the injured cartilage, it did prevent chondrocyte apoptosis.
The authors also pointed out that the application of chondrogenic factors could regulate the differentiation, proliferation, and metabolic activity of MSC and have been shown to increase the therapeutic efficacies of MSCs.
The 3D environment provided through scaffolding has a crucial role in maintaining the chondrocyte phenotype of MSCs, primarily by enabling the homogeneous distribution of MSCs and providing appropriate substrate for cell growth and mechanical integrity for post-surgical implantation. According to Le et al. using this approach could induce the regeneration required for complete and functional cartilage tissue.
While there is still much to be investigated in the area of using MSC-based therapies to create bionic tissues, the authors conclude that the integration of these therapies into current clinical approaches will overcome the current existing challenges and result in a biomimetic cartilage regenerative therapy. Source: Le H, Xu W, Zhuang X, Chang F, Wang Y, Ding J. Mesenchymal stem cells for cartilage regeneration. J Tissue Eng. 2020;11:2041731420943839. Published 2020 Aug 26. doi:10.1177/2041731420943839
In recent years, the field of regenerative medicine has made remarkable strides, with stem cell therapy emerging as a revolutionary approach to treating various conditions. Among the most promising applications of stem cell therapy is its use in orthopedic injuries, which include conditions such as sports injuries, osteoarthritis, and degenerative disc disease. This innovative treatment has the potential to transform the way we approach the healing and recovery process for these conditions, offering hope for faster and more effective recovery.
Understanding Stem Cell Therapy
Stem cell therapy involves the use of stem cells to repair, regenerate, or replace damaged or diseased tissues in the body. Stem cells are unique in their ability to differentiate into various types of cells, making them ideal candidates for treating a wide range of medical conditions. In orthopedic injuries, stem cells can be used to promote the healing of damaged cartilage, tendons, ligaments, and bones.
Mesenchymal stem cells (MSCs) are adult stem cells found in bone marrow, adipose tissue, and umbilical cord tissue. MSCs are commonly used in orthopedic treatments due to their ability to differentiate into bone, cartilage, and muscle cells.
Stem Cell Therapy for Orthopedic Injuries
Orthopedic injuries can result from trauma, overuse, or degenerative conditions, and they often affect the musculoskeletal system, including bones, joints, and soft tissues. Common orthopedic injuries that may benefit from stem cell therapy include:
Sports Injuries: Athletes are particularly susceptible to injuries such as ligament tears, tendonitis, and muscle strains. Stem cell therapy can accelerate the healing process, reduce inflammation, and promote the regeneration of damaged tissues. For instance, studies have shown that stem cell therapy can be effective in treating anterior cruciate ligament (ACL) injuries, a common sports injury that can sideline athletes for months (Oxford Academic).
Osteoarthritis: Osteoarthritis is a degenerative joint disease characterized by the breakdown of cartilage, leading to pain, stiffness, and reduced mobility. Traditional treatments for osteoarthritis primarily focus on symptom management, but stem cell therapy offers a more targeted approach. By injecting stem cells into the affected joint, it’s possible to stimulate cartilage regeneration and reduce inflammation, potentially slowing or even reversing the progression of the disease (BioMed Central).
Degenerative Disc Disease: This condition occurs when the intervertebral discs, which act as cushions between the vertebrae, begin to deteriorate, leading to back pain and discomfort. Stem cell therapy can help regenerate the damaged disc tissue, reduce pain, and improve function. Research has shown promising results in using stem cells to treat degenerative disc disease, offering patients an alternative to invasive surgical procedures (SpringerLink).
How Stem Cell Therapy Works for Orthopedic Injuries
The process of stem cell therapy for orthopedic injuries typically involves several key steps:
Harvesting Stem Cells: Depending on the source of the stem cells, they can be harvested from the patient’s bone marrow, adipose tissue, or from donor sources such as umbilical cord tissue. The cells are then processed and prepared for injection.
Injection: The concentrated stem cells are then injected directly into the injured area using imaging guidance such as ultrasound or fluoroscopy to ensure precise delivery. In some cases, multiple injections may be required over time to achieve optimal results.
Recovery and Monitoring: Following the procedure, patients are monitored to assess their response to the therapy. Recovery times can vary, but many patients begin to notice improvements within weeks to months after the treatment.
Benefits of Stem Cell Therapy for Orthopedic Injuries
Stem cell therapy offers several advantages over traditional treatments for orthopedic injuries:
Minimally Invasive: Unlike surgical interventions, stem cell therapy is minimally invasive, involving only injections rather than incisions. This reduces the risk of complications and shortens recovery times.
Reduced Pain and Inflammation: Stem cells have anti-inflammatory properties that can help reduce pain and swelling at the injury site, promoting faster healing.
Promotes Tissue Regeneration: One of the most significant benefits of stem cell therapy is its ability to promote the regeneration of damaged tissues, which can lead to more durable and long-lasting recovery.
Potential to Delay or Avoid Surgery: For conditions like osteoarthritis or degenerative disc disease, stem cell therapy may help delay or even eliminate the need for surgical intervention, providing a less invasive treatment option.
Customizable Treatment: Stem cell therapy can be tailored to the specific needs of the patient, allowing for personalized treatment plans that address the unique aspects of each injury.
Challenges and Considerations
While stem cell therapy holds great promise, it is important to acknowledge that it is still a relatively new field, and there are challenges to be addressed:
Variability in Outcomes: The effectiveness of stem cell therapy can vary depending on factors such as the type of injury, the source of stem cells, and the patient’s overall health. More research is needed to establish standardized protocols and determine the best practices for different conditions.
Regulatory and Ethical Considerations: The use of certain types of stem cells, such as embryonic stem cells, raises ethical questions and is subject to strict regulations. However, the use of adult stem cells, including MSCs, is generally considered ethical and is more widely accepted.
Cost and Accessibility: Stem cell therapy can be expensive, and it is not covered by insurance. This can limit access for some patients, particularly those who may benefit most from the treatment.
The Future of Stem Cell Therapy in Orthopedics
As research in stem cell therapy continues to advance, its potential applications for treating orthopedic injuries are expanding rapidly. The ongoing development of new techniques for harvesting, processing, and delivering stem cells is likely to improve the effectiveness and accessibility of these treatments. Scientists are also exploring ways to enhance the regenerative capabilities of stem cells through genetic modifications and the use of bioengineered scaffolds, which could lead to even more impressive outcomes.
In the future, stem cell therapy may become a standard treatment for a wide range of orthopedic conditions, from sports injuries to degenerative diseases like osteoarthritis and degenerative disc disease. This would offer patients a minimally invasive option that promotes natural healing and regeneration, potentially reducing the need for more invasive surgical procedures.
Conclusion
Stem cell therapy is revolutionizing the field of orthopedic medicine, offering a promising new approach to treating injuries and degenerative conditions. By harnessing the body’s natural healing processes, stem cell therapy has the potential to improve outcomes, reduce recovery times, and enhance the quality of life for patients suffering from orthopedic injuries. While challenges remain, the continued advancement of stem cell research holds the promise of making these treatments more effective and accessible to a broader range of patients in the near future.
References and Further Reading
To learn more about the studies and research supporting the use of stem cell therapy in orthopedic injuries, you can explore the following references:
These references provide a deeper dive into the science behind stem cell therapy and its growing role in the treatment of orthopedic conditions. As this field continues to evolve, it offers exciting possibilities for improving patient care and outcomes in orthopedics.
As the human body ages, most people assume that “wear and tear” will take over and deplete their health. This isn’t always true, and it’s important to separate fact from fiction when discussing joint health problems.
Osteoarthritis is a painful, inflammatory joint condition that can make it difficult to function. Some folks refer to it as “just” arthritis, but this minimizes the incredible discomfort and damage it causes. Living with this condition can feel impossible at times.
You don’t have to sit back and let joint health problems take over your life as you age. Learn more about osteoarthritis so you can make the best decisions for your health and pain management.
Developing Osteoarthritis: What’s Happening to Your Joints?
Before you can appropriately manage this condition, you must learn what’s happening in your joints. Developing osteoarthritis is not inevitable, but unfortunately, it is common, especially in aging adults.
What Is Osteoarthritis?
Osteoarthritis is an inflammatory joint condition that occurs when the cartilage that supports and connects your bones wears away. As a result, your bones grind together, and the spaces around your joints become inflamed and tender.
Is This Condition Inevitable?
No. Osteoarthritis is not just a “normal” part of aging, nor is it inevitable. As science and research advance, it’s becoming more obvious that osteoarthritis is the result of many risk factors interacting with each other.
Certain risk factors make it more likely that you’ll develop osteoarthritis. Many of them are preventable through lifestyle changes and a proactive approach to protecting your joints.
Who Gets Osteoarthritis?
Age is a big risk factor for osteoarthritis, but again, this condition is not inevitable. Here are some of the risk factors for developing osteoarthritis.
Stress, Strain, and Injury
Any type of strain or stress on your joints can lead to osteoarthritis later in life. Even if your joints feel fine when you’re younger, you’re still at risk if you’ve experienced harsh impacts or prolonged joint strain.
Sports injuries, obesity or being overweight, and physically demanding jobs all put you at a higher risk of developing osteoarthritis. All these risk factors slowly degrade the cartilage between your bones. These tissues can only support lots of impact, weight, or use for so long.
Genetics and Sex
Your genetics play a role in whether you develop joint health problems. Having a family history of osteoarthritis raises your chances of dealing with the same condition.
An estimated 60% of osteoarthritis patients are women. This means that if you were assigned female at birth, you’re at a slightly increased risk of developing osteoarthritis. However, through a healthy lifestyle, you may be able to prevent it.
The Silent Pain of Living with Arthritis
To the outside world, you might appear healthy and fully capable of living your daily life as normal. However, arthritis pain can stop you in your tracks. It can be intense or even disabling.
If your condition gets bad enough, you might find yourself unable to walk around, twist, or pick things up. Osteoarthritis pain is not something to ignore or minimize.
Swelling and Inflammation
The inflammation doesn’t just happen inside your body. Sometimes, your joints may become swollen, tender, and visibly inflamed. When this happens, chances are you can’t move the affected joints much. Any impact, no matter how slight, may throw you into a pain flare.
Crepitus
Some osteoarthritis patients experience a crunching or grinding sensation (crepitus) when moving the affected joints. This can be terrifying and uncomfortable, leading to increased mental stress and physical pain.
Weakness and Limited Mobility
Osteoarthritis causes muscle weakness, fatigue, and limited mobility. You might not be able to move your body in ways that feel good to you or allow you to keep up with others anymore. These limitations not only affect you physically, but they also come with a mental price tag as well.
Stigma and Shame Around Aging
Some people might feel like their osteoarthritis symptoms mean they’re “getting old.” While there should be no shame in aging, social stigmas suggest otherwise. Experiencing these symptoms might make you feel embarrassed about your age.
If you struggle with joint pain, others might not see what you go through. You might feel pressured to “just get over it” or take pain medication to keep up with everyone else. This can also create feelings of shame and contribute to a poor stigma around joint health problems.
Treating Osteoarthritis: Enjoy a Better Quality of Life
Getting an osteoarthritis diagnosis doesn’t mean you’ll never be able to enjoy life and movement again. With the proper therapies, especially early treatment, you can improve your comfort and quality of life. Here are some of the best options for treating osteoarthritis pain and inflammation.
Stem Cell Therapy
Stem cells are at the forefront of regenerative medicine. These cells, also known as “blank” or “programmable” cells, can develop into specialized tissues, like cartilage. This makes them useful for regenerating and healing wounds, damaged tissues, and inflamed areas of your body.
One advantage of stem cell therapy is that it’s drug-free and comes with almost no risks to your health.
Stem cell therapy may also reduce your pain and increase your mobility. It gets to the root cause of your joint problems instead of covering up the symptoms.
Exercise and Physical Therapy
Getting more movement in your day may help reduce the severity of your osteoarthritis symptoms. Regular physical activity prevents the painful stiffness that osteoarthritis patients often experience.
Exercise also assists in weight management, which is key to reducing your joint pain. Every extra pound of body fat adds about four times the amount of pressure onto your joints.
Whether you (gently) exercise on your own or enlist the help of a physical therapist, your joints will thank you for it.
Get the Proper Support for Your Osteoarthritis
Living with osteoarthritis can be challenging, but you’re not alone. There are steps you can take to improve your quality of life with this condition. Evaluate your treatment options to find what works best for you. Visit our website to learn more about osteoarthritis pain.
Living with any type of arthritis is painful, debilitating, and frustrating. You miss out on a lot of the physical activities you used to love. This condition can even make it harder to keep up with children and grandchildren.
Your long-term health is worth fighting for. When it comes to osteoarthritis pain management treatments, it’s important to know your options. Here are some pain relief methods to try when managing your osteoarthritis over time.
How Osteoarthritis Develops and Becomes So Painful
The joint pain and inflammation alone can keep you off your feet for days. Along with severe pain, osteoarthritis also causes damage to your cartilage and joints, affecting your mobility and activity levels.
Cartilage Breakdown Leads to Joint Pain
If you’ve dealt with osteoarthritis pain, you might wonder what led you to develop this condition. The root cause of osteoarthritis is cartilage degradation. This means that the rubbery cushion between your bones starts to thin and eventually wear away entirely.
When your joints no longer have adequate cushioning or support between them, they start to rub together. This leads to inflammation, irritation, and intense pain. As the bones rub together, they also break down and lose some of their function.
Risk Factors for Developing Osteoarthritis
There is no single universal cause of osteoarthritis. Certain risk factors can increase your chances of developing this condition. If you have multiple risk factors at once, your chances are even higher.
Some risk factors for developing osteoarthritis include:
These risk factors don’t guarantee you will develop osteoarthritis, but they do play large roles in this condition.
Continuous Inflammation and Discomfort
Osteoarthritis can feel like a never-ending cycle. Once your joints start grinding against one another, you develop inflammation, which leads to even more pain and discomfort.
Over-the-counter anti-inflammatory medications may not resolve your pain, and they certainly don’t treat the root cause of it. In order to experience osteoarthritis relief, you need to prevent the inflammation from occurring in the first place.
At-Home Remedies and Lifestyle Changes
You may be able to control your osteoarthritis pain with lifestyle modifications. This means changing how you move, eat, sleep, and respond to stress in your daily life. Try these at-home therapies and improvements if you want to take the natural pain treatments for osteoarthritis.
Flexibility and Mobility Exercises
You must be careful when exercising with osteoarthritis. Some high-impact activities can make your pain worse. However, strength training, conditioning, and mobility exercises can improve your condition.
Certain stretches and gentle movements can help support your joints and reduce the burden on your bones. This ultimately leads to reduced pain and more mobility over time.
Cold Therapy
Cold temperatures can help reduce inflammation and swelling near your joints. This is because cold conditions trigger a restrictive mechanism in your blood vessels, reducing the blood and fluid supply to the affected areas. If you struggle with inflamed cartilage and joints, cold therapy might be just what you need.
Try applying an ice pack or sitting in an ice bath (with a doctor’s approval) for up to 20 minutes. It’s best to alternate cold and hot applications for the best results.
Heat Therapy
Similar to cold therapy, heat therapy works by changing the blood flow around your inflamed joints and cartilage. Heat opens up your blood vessels, allowing more blood and fluid to reach the affected area. This can supply oxygen, nutrients, and regenerative compounds to your joints.
Alternate applications of hot and cold compresses, using each for up to 20 minutes. You should experience a temporary reduction in swelling and discomfort.
Rest and Sleep
Getting plenty of rest is essential for restoring your joint and cartilage health. Your body needs sleep to rebuild damaged tissues and relieve pain effectively. If your pain is debilitating, try resting the affected area for a few days and catching up on some much-needed shut-eye.
Natural Joint Pain Treatments
From acupuncture to massage, many patients benefit from alternative pain relief therapies. If you want to avoid over-the-counter drugs, these natural pain treatments might be right for you.
Therapeutic Massage
You can perform self-massages at home or go to a licensed professional for these services. Either way, massage has been shown to improve blood circulation to injured areas and relieve some pain and discomfort. You may even notice improvements in your mobility after a restorative massage.
Acupuncture
Acupuncture uses tiny needles to activate trigger points in your body and release tension and pain. Some patients have experienced noticeable improvements in their osteoarthritis pain after regular acupuncture treatments. Contact an acupuncturist to see if this therapy is right for you.
Regenerative Medicine: Stem Cell Therapy for Osteoarthritis Pain
Stem cell therapy is a drug-free alternative you can use to treat your osteoarthritis pain. The potential healing properties of your body’s “blank cells” may lead your joints and cartilage to strength and health again.
How Stem Cells May Relieve Your Pain
Stem cells can be programmed to develop into almost any kind of cell your body needs. In osteoarthritis patients, this means turning them into cartilage tissue.
Stem cells may be able to regenerate damaged soft tissues around your joints, leading to more comfortable movements. This can help you regain some mobility and experience lower pain levels over time.
Low Risk of Side Effects
When you’re dealing with debilitating joint pain, the last thing you want is painful side effects from the treatment you’ve chosen. Stem cell therapy is known for its high safety profile since it uses human cells to regenerate damaged tissues. This means there’s little to no risk of adverse reactions.
Stem cell treatments are fast, generally safe, and potentially very effective at treating osteoarthritis pain. If you want to try a new avenue for joint pain relief, consider regenerative medicine.
Tackle Your Arthritis Pain Your Way
You have the final say in how you treat your osteoarthritis pain. Whether you opt for natural at-home remedies or test out regenerative medicine, what’s important is that you have choices. Take control of your health and mobility again with these pain management treatments for osteoarthritis.
This website and its contents are not intended to treat, cure, diagnose, or prevent any disease. Stemedix, Inc. shall not be held liable for the medical claims made by patient testimonials or videos. They are not to be viewed as a guarantee for each individual. The efficacy for some products presented have not been confirmed by the Food and Drug Administration (FDA).
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