Primarily a result of its avascular structure and the relatively low metabolic activities of chondrocytes, cartilage has demonstrated a very limited ability to self-repair. Currently, the primary interventions for cartilage-related injuries only postpone further cartilage deterioration and fail to fully restore or repair cartilage. The limited success of current clinical treatment options for cartilage-related injuries…
Repairing the structure and functionality associated with subcutaneous cartilage defects continues to be a challenge in the fields of plastic and reconstructive surgery. While current methods, including autologous chondrocyte implantation and matrix-assisted chondrocyte implantation, have been successful in some regard, they continue to present a number of limitations, including donor limitation, donor morbidity, and degradation…
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