Renal Hypertension Signs, Symptoms, and Treatments

Renal Hypertension Signs, Symptoms, and Treatments

You might think of kidney health problems as separate issues from your blood pressure. However, renal hypertension, a form of high blood pressure, can be just as serious as cardiovascular health conditions. 

It’s important to understand the link between kidney function and blood pressure. Once your kidneys become compromised, the damage isn’t reversible. Know the signs, symptoms, and treatment options related to renal hypertension so you can maintain your kidney health as long as possible. 

How Renal Hypertension Develops

Your kidneys work with the rest of your body to maintain your blood pressure, fluid and sodium balance, pH levels, and more. When either your kidneys or the rest of your body is thrown out of balance, the other can suffer. 

Narrowed Kidney Arteries

Renal hypertension has the same cause as standard high blood pressure — the narrowing of arteries. With this disease, the arteries that are most compromised are the ones that lead into your kidneys. This can be very dangerous if left untreated. 

Many different factors can cause narrowed kidney arteries, including atherosclerosis (plaque buildup), scarring due to general hypertension, and others. When this happens, you’re at an increased risk of developing renal hypertension. 

Your Kidneys’ Response

When your kidneys aren’t getting enough blood flow — which is a common issue when your arteries narrow — they release certain hormones. These hormones cause your blood pressure to rise in an attempt to get more blood flowing to your kidneys. 

The Vicious Cycle of Renal Hypertension

Renal hypertension is a real problem, particularly if it progresses for a long time. Once your kidney blood flow is compromised, your kidneys stop working as efficiently. 

One of the primary functions of your kidneys is to balance sodium and water levels in your body. Compromised kidneys won’t filter sodium out of your system as effectively. When there’s too much sodium circulating, you experience high blood pressure, and the hypertension cycle continues. 

Chronic hypertension can contribute to the development of kidney disease, which has no cure. Many experts consider kidney disease to be the root cause of renal hypertension, but general hypertension plays a large role as well. 

Common Signs and Symptoms of Renal Hypertension

You might be wondering if this problem will affect you, especially if you’ve already been diagnosed with general hypertension. There are key signs and symptoms to look out for. You should also consult closely with a physician who can monitor your blood and kidney health consistently. 

Headaches

In some cases, high blood pressure will cause headaches or migraines. Scientists believe this happens because of changes in the blood-brain barrier. Pressure can build in this region during high blood pressure episodes, leading to discomfort, pain, and migraine headache symptoms. 

Vision Changes

Extremely high blood pressure levels can damage the arteries and blood vessels in your eyes. This leads to double vision, blurriness, and general difficulty seeing. If you experience sudden changes in your vision, renal hypertension may be the culprit. 

Confusion

Your brain can’t function properly when your blood pressure is too high. This symptom is usually a sign that you’re in a hypertensive crisis and need immediate medical attention. If you start feeling confused, dazed, or mentally foggy, consider renal hypertension as the root cause. 

Nausea and Vomiting

Hypertensive crises usually induce nausea and, in some cases, bouts of vomiting. This is another critical symptom to watch for, as it means you need emergency medical treatment. 

An Important Note

Renal hypertension, much like general hypertension, usually shows no symptoms. This is why it’s so dangerous, as patients may not know they have this condition until it’s too late. It’s essential to work with a specialist who can keep an eye on your blood pressure and kidney health if you have concerns. 

It’s also important to note that kidney problems are mostly irreversible. While there are some promising treatments, like stem cell therapy for kidney disease, there is no known cure yet. Prevention is the key to managing your kidney health. 

Potential Treatments for Better Kidney Health 

Lifestyle changes and innovative treatments, namely regenerative medicine, may improve your kidney health over time. If your doctor has stated that you don’t need surgery to treat your renal hypertension, stem cell therapy may be right for you. 

Lifestyle Changes to Lower Your Blood Pressure

Eating a diet low in sodium and free from added table salt can do wonders for your blood pressure levels. Your doctor may recommend that you make other lifestyle changes, like exercising daily and quitting smoking. These changes take time to get used to, but they can save your kidneys a lot of damage in the long run. 

Blood Pressure Medication

This intervention is tricky because a key sign of renal hypertension is rising blood pressure that won’t respond to medication. However, in some cases, your doctor may be able to control your hypertension with a stronger blood pressure drug. This is usually the first line of treatment if you’re unable to make the necessary lifestyle changes. 

Surgery 

There are both minimally invasive and open surgical procedures for treating renal hypertension. Surgical interventions involve installing a balloon into the affected artery or using healthy tissue from a different artery to repair the damaged one. Either way, these interventions require a surgeon who specializes in these procedures. 

Stem Cell Therapy 

Regenerative medicine involves using stem cells to treat and protect damaged tissues in the body. Mesenchymal stem cells have shown some promise in treating ischemic kidney disease and restoring health to damaged blood vessels. 

Stem cells can be programmed to have anti-inflammatory properties, which reduces tissue damage throughout your body. When the affected area — in this case, your kidneys — receives stem cell therapy, damaged vessels and arteries might slowly heal and regenerate. 

Regenerative medicine is drug-free and uses the natural healing properties of “blank” stem cells to assist in wound healing and tissue regeneration. Stem cell treatments may be a good option for treating your renal hypertension if you want to avoid surgery, medication, and other invasive interventions. 

Renal Hypertension Prevention, Treatment, and Healing

You have options when it comes to preventing and treating your renal hypertension. Prevention is always the best way to avoid long-term complications. However, don’t be discouraged if the damage is already done. With the right information, you can make an informed decision on caring for your kidneys. 

A New Therapeutic Strategy for Cardiovascular Diseases Utilizing Exosomes 

A New Therapeutic Strategy for Cardiovascular Diseases Utilizing Exosomes 

Cardiovascular diseases continue to be the leading cause of death globally, accounting for nearly 18 million deaths each year with heart attack and stroke accounting for 80% of deaths.

Recently, stem-cell-based therapy has demonstrated the potential to regenerate damaged myocardium and to treat a wide range of cardiovascular diseases (CVDs). Specifically, the ability of mesenchymal stem cells (MSCs) to differentiate into cardiomyocytes, endothelial cells, and vascular smooth muscle cells has created a potentially new and promising therapeutic approach for the treatment of CVDs.

Huang et al. summarize the recent advances in MSC therapy, including the role of exosomes in future treatments of CVDs. 

Recent studies have demonstrated that MSCs were able to secret cholesterol-rich, phospholipid exomes that were enriched with microRNAs (miRNAs). These exomes are nano-sized particles originating from multivesicular endosomal ranging in size from 30 – 100 nm and contain cytokines, proteins, lipids, mRNAs, and miRNAs. These exosomes are suggested as central mediators of intercellular communication and transfer proteins, mRNAs and miRNAs to adjacent cells.  

The miRNAs found in exosomes play an essential role in various physiological and pathological processes by regulating gene expression at the post-transcription level. When applied in the cardiovascular system, miRNAs are internalized into CMCs and ECs and result in cardiomyocyte protection and angiogenesis promotion that has demonstrated beneficial and anti-inflammatory effects including cardiac regeneration, neovascularization, and anti-vascular remodeling; these observed benefits include improved cardiac function after a myocardial infarction (MI), reduced inflammation related to pulmonary hypertension, and increased tissue healing following an ischemia-reperfusion injury.

Huang et al. conclude that the studies evaluated in this review provide evidence that MSC-derived exosomes play an essential role in MSC-based therapy of CVDs including MI, reperfusion injury, and PH. Considering these conclusions, the authors call for additional studies to determine the detailed mechanisms and underlying benefits to determine their exact role. 

Source: “Exosomes in Mesenchymal Stem Cells, a New Therapeutic Strategy ….” 12 Jan. 2015, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308409/.

Can Stem Cell Therapy Treat Cardiovascular Disease?

Can Stem Cell Therapy Treat Cardiovascular Disease?

Cardiovascular disease is the leading cause of death across the world. This umbrella term, also referred to as heart disease, collectively includes a broad range of cardiovascular conditions, including:

  • Heart failure
  • Coronary artery disease
  • Cardiomyopathy
  • Myocardial infarction (heart attack)
  • Ischemic stroke

While these conditions have unique characteristics, they all affect the heart and blood vessels. For instance, in coronary artery disease, the most common cardiovascular disease, the buildup of plaque (known as atherosclerosis) narrows or blocks the arteries. The arteries harden, limiting the amount of oxygen-rich blood that makes its way to the heart. The heart can therefore not pump blood to the rest of the body as needed. In myocardial infarction, or heart attack, blood clots around the plaque. If the blood flow becomes completely restricted, the heart can no longer get necessary oxygen. In ischemic stroke, the clot prevents the blood flow to the brain. 

There are several lifestyle treatments which may help to control cardiovascular disease, including:

  • Smoking cessation
  • Weight regulation
  • Maintaining a healthy diet
  • Routine exercise
  • Controlling blood pressure and cholesterol

There are also medications and surgical interventions available for certain types of heart disease. With that being said, experts are also exploring stem cell therapy as an alternative or additional treatment. 

Stem Cell Therapy for Cardiovascular Disease

Stem cell therapy is the use of the body’s natural, versatile cells to promote healing. Stem cells act as the foundation for other cells and have natural anti-inflammatory properties. As such, they can promote healing in damaged cells and tissues, as well as regeneration. When transplanted into patients with cardiovascular disease, it’s believed that the cells could release healing factors to reduce inflammation, promote new blood vessel development, minimize cell death, and regenerate new, healthy cells.

According to ClinicalTrials.gov, there are more than 1,500 studies that have been or are being conducted regarding the use of stem cells in patients with cardiovascular disease. Scientists have already made strides by discovering several key benefits across a number of cardiovascular conditions. For example, stem cells have been shown to:

  • Improve left ventricular function, blood flow, and quality of life following a heart attack.
  • Improve the heart’s functional capacity and ventricular remodeling, as well as quality of life, in heart failure.
  • Enhance cardiac function in ischemic stroke
  • Improve limb function and decrease muscle atrophy, autoamputation, and connective tissue damage in peripheral artery disease (PAD). 

In particular, human umbilical cord mesenchymal stem cells are showing remarkable promise for chronic conditions such as heart disease. They have a number of powerful properties, including:

  • No exposure to environmental toxins or impact from the aging process
  • High rate of regeneration
  • High proliferation ability
  • Abundant supply of cells compared to those extracted from adipose tissue or bone marrow

These cells are administered intravenously, and because they are not sourced from the patient themselves, minimize discomfort and recovery time. While stem cell therapy may not be for every patient with cardiovascular disease, the right candidates seeking a safe, non-surgical option may wish to explore the treatment. If you’re interested in exploring stem cell therapy, contact a Care Coordinator for a free assessment!

Subscribe To Our Newsletter

Subscribe To Our Newsletter

Join our mailing list to receive the latest news and updates from our team.

You have Successfully Subscribed!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!

Request Information Packet

We'll send your FREE information packet that outlines our entire personalized, stress-free stem cell treatment process!

Thanks for your interest!