by admin | Oct 9, 2019 | Stem Cell Research, Age Management, Stem Cell Therapy
Frailty is a syndrome of weight-loss, exhaustion, weakness, slowness, and decreased physical activity. These features combine to make frail individuals more susceptible to physical, psychosocial, and cognitive impairments. Unfortunately, frailty is rather common among elderly individuals. In one study of over 44,000 elderly adults living in the community estimated the overall prevalence of frailty was 10.7%. While the risk of becoming frail increases with old age, frailty is not a normal part of aging. Instead, the syndrome of frailty is driven by biological processes such as inflammation and stem cell dysfunction.
No specific treatment can prevent or reverse frailty. Indeed, the goal of treatment is to maximize the patient’s functional capacity and overall health. The most widely accepted way to manage frailty is a multimodal and multidisciplinary approach. Frail individuals or those at risk for becoming frail are encouraged to participate in strength training and aerobic exercise to build up a cardiovascular reserve and physical fitness. At the same time, substantial efforts are devoted to helping patients consume enough calories to maintain lean muscle and support their immune function. As appetite diminishes, malnutrition can become an issue, so supplemental nutrition may be needed. Physicians can help patients by optimizing medical treatments and reducing the total number of medications prescribed (i.e. avoiding polypharmacy).
Despite these multimodal treatments, most frail patients tend to get worse over time. One hope of treatment is to slow the rate of decline; however, this is not always possible.
Since frailty is driven by stem cell dysfunction, a reasonable way to prevent or treat frailty could be to provide patients with healthy stem cells. Researchers recently conducted a randomized, double-blind, clinical trial in 30 elderly patients with frailty. Frail patients received an IV infusion of either human mesenchymal stem cells or placebo. The researchers then followed the patients for 6 months to assess the safety and efficacy of the stem cell treatment.
Stem cell treatment resulted in a rather remarkable set of benefits for frail patients. Compared to placebo, patients treated with stem cells performed significantly better on tests of physical strength and stamina. Stem cell-treated patients used calories more efficiently, which is a sign that they were more physically fit than those in the placebo group. Moreover, patients who received stem cells had better lung function at the end of the trial than those in the control group. Interestingly, women who received stem cell treatment reported a substantial increase in sexual quality of life compared to those in the placebo group. Lastly, no patients experienced any treatment-related serious adverse events.
When one considers how difficult it is to treat frailty or even alter its progressive decline, these results are remarkable. Stem cell treatment not only stopped the progression of frailty, but patients actually improved in several important measures including physical strength, physical endurance, lung function, and sexual quality of life. We anxiously await a pivotal clinical trial to confirm these results.
Reference: Tompkins, BA. (2017). Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. The Journals of Gerontology, Series A, Biological Sciences and Medical Sciences. 2017 Oct 12;72(11):1513-1522.
by admin | Oct 1, 2019 | Aesthetics, Stem Cell Research, Stem Cell Therapy
You don’t need a microscope to recognize aging skin. Aging skin has fine lines and wrinkles; it sags because it has lost elasticity; it is discolored and blotchy. But if you did look at aging skin under a microscope, you would notice that it lacks collagen, elastin, and many other helpful proteins. There would be many old cells and a few young ones. Indeed, old skin looks different under a microscope than new skin, and it is these differences at the cellular level that causes the aging we see on people’s faces. Stem cell facial therapy may be an option for one seeking to improve or prevent the signs of aging.
Fortunately, these cellular changes may not be a curse. Stem cell therapy may be able to replace the proteins that are lost during aging and replace old cells with newer, healthier cells. In short, stem cell facial therapy may be able to can rejuvenate skin and reverse the signs of aging.
The team of Korean stem cell researchers recently completed a study in which they collected mesenchymal stem cells from various sources and used them to rejuvenate human skin. The researchers collected stem cells from fat tissue (adipose), bone marrow, and umbilical cord samples. Umbilical cord tissue is tissue that is normally discarded after childbirth as medical waste. In the laboratory, the scientists then cleaned and purified each of these types of mesenchymal stem cells.
In laboratory studies, the researchers found that mesenchymal stem cells produced substantial amounts of skin rejuvenating factors including collagen type I, collagen type IV, fibronectin, and elastin. Interestingly, they found that umbilical cord mesenchymal stem cells produced a 100-fold greater amount of GDF-11 than adipose or bone marrow stem cells. This is important because GDF-11 is a cytokine that stimulates the production of collagen and elastin. GDF-11 also attracts human dermal fibroblasts (i.e. healthy skin cells) that then, in turn, produce their own collagen and elastin. These substances make skin healthy, elastic, vibrant, plump, and full.
Given the remarkable amounts of GDF-11 that umbilical cord-derived stem cells produced, the researchers decided to conduct a clinical trial to test the effect of these cells on aging skin. The scientists created a cream that contained the substances produced by the stem cells, including exosomes and beneficial proteins. The women who volunteered for the study applied the cream to their faces once per day. Within 2 to 4 weeks, the women had increased skin density (i.e. thickness/fullness) and substantially reduced wrinkles, especially around the eyes. Moreover, treatment with the stem cell-derived cream did not cause irritation, stinging, or any other adverse reaction.
This clinical study will need to be repeated in larger numbers of volunteers; however, the results are quite remarkable. Researchers were able to collect stem cells from umbilical cord tissue and prepare a cosmetic that reversed some of the signs of facial aging. Conveniently, this treatment did not require injections but could be applied topically. If future research confirms this work, treatment with a cosmetic/cosmeceutical made from umbilical cord stem cells could be a painless way to achieve facial skin rejuvenation.
Reference: Kim, YJ. (2018). Conditioned media from human umbilical cord blood-derived mesenchymal stem cells stimulate rejuvenation function in human skin. Biochemistry and Biophysics Reports. 2018 Oct 25;16:96-102.
by admin | Aug 21, 2019 | Adipose, Aesthetics, Hair Regrowth
Alopecia, better known as hair loss, is a cosmetic problem. People do not need hair on their scalp to survive. Nonetheless, people with thinning hair or hair loss often endure considerable distress and suffering. Hair loss can cause low self-esteem, symptoms of depression, and a diminished quality of life. So while hair loss may be a simple cosmetic, strictly speaking, many people with alopecia struggle with an ongoing and serious problem.
Unfortunately, there are few effective treatments for hair loss. The two main medical treatments for hair loss are minoxidil and finasteride. Finasteride is generally only useful for male pattern baldness. Both men and women can use minoxidil, but it, too, is only partially effective. Various surgeries can be used to treat hair loss such as hair transplantation, scalp reduction, and scalp expansion, but patient satisfaction rates for these procedures are fairly low.
Stem cells that have been derived from fat tissue (i.e. adipose) secrete a number of beneficial chemicals called cytokines. These cytokines are important for wound healing and new blood vessel growth (i.e. angiogenesis). Cytokines released by adipose-derived stem cells are also able to stimulate hair follicles and induce the growth of hair. Based on these successes in the laboratory, dermatologists in Japan have used the substances secreted by adipose-derived stem cells to help people with hair loss.
Drs. Fukuoka, Narita, and Suga published a report detailing their successes in treating hair loss with proteins extracted from adipose-derived stem cells. A single hair loss treatment involves making a number of very small injections into the scalp. Each patient usually needs 6 to 8 treatment sessions, given once per month.
The doctors have performed this stem cell-based hair loss treatment on more than 1,000 patients and they have not encountered a single allergic reaction or infection. Indeed, no serious complications have occurred in their patients.
Not only is this stem cell-based hair loss treatment safe, but it is also apparently effective, as well. Patients have new growth of thin hair after two or three treatments, but this is minor and can usually only be detected by the doctors. After the fourth or fifth treatment, however, patients often notice new hair growth. By the sixth treatment, most patients can easily see new hair growth.
To confirm the effectiveness of their treatment, the doctors performed a half-side comparison test. In this test, they injected the stem cell-based hair loss treatment on one side of the scalp and injected saline on the other. The side of the scalp that received the stem cell extract had significantly more hair growth than the saline-treated side. This is strong evidence that the treatment is effective.
Reference: Fukuoka H. et al. (2017). Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells. 2017;12(7):531-534.
by admin | Mar 23, 2019 | Hyperbaric Oxygen Therapy, Parkinson's Disease, Stem Cell Therapy, Studies
Parkinson’s disease is widely known as a neurological condition that causes motor symptoms. Typically, patients with Parkinson’s disease have pill-rolling tremor, cogwheel rigidity, and a shuffling gait. However, about half of all patients with Parkinson’s disease also have psychiatric symptoms such as anxiety and depression. It can be challenging for patients and caregivers to deal with Parkinson’s disease, but if anxiety and depression are also present, it can make matters worse. When psychiatric symptoms occur, they can make Parkinson’s disease more difficult to treat, increase the burden on caregivers, and greatly reduce quality-of-life for patients.
One of the things that make psychiatric symptoms so difficult to treat in patients with Parkinson’s disease is that doctors have limited treatment options. The antidepressants that they would normally use to treat depression and anxiety can make motor symptoms of Parkinson’s disease worse. People with Parkinson’s disease often struggle with sleep disturbances, and typical antidepressants can make sleep problems worse, too. Not surprisingly, many patients with Parkinson’s disease suffer from depression and anxiety and never find adequate treatment.
Physicians recently reported their experience with a patient with Parkinson’s disease who they treated with hyperbaric oxygen. The man had struggled with Parkinson’s disease for 1.5 years and had slipped into a severe depression. He had lost interest in pleasurable activities, was only sleeping about 2 to 3 hours each night, unintentionally lost over 40 pounds, and was having thoughts of suicide. He also had significant anxiety issues that made his life very difficult. Regular drug and psychotherapy treatments for anxiety and depression did not work for this man, so physicians were left with few options.
The man with Parkinson’s disease, severe depression, and anxiety underwent 30 days of hyperbaric oxygen treatments. He inhaled pure oxygen in a hyperbaric chamber for 40 minutes per session at 2 atm of pressure. In as little as four days of hyperbaric oxygen treatment, the man was sleeping better and longer than he did before treatment. His mood has also improved.
After 30 days of hyperbaric oxygen treatments, the man was able to sleep for 8 to 10 hours a night. Not only did his psychiatric symptoms improve, but his Parkinson’s disease symptoms also improved. While he still had Parkinson’s disease symptoms after hyperbaric oxygen treatment, the symptoms had improved substantially.
When physicians followed up one month after treatment had ended, the patient was still sleeping through the night, his mood was good, and he did not need assistance with his activities of daily living.
It is important to remember that this is a case study, the results of a single patient. Nevertheless, the improvements in both Parkinson’s disease and severe symptoms of anxiety and depression are incredibly impressive. For this man, at least, hyperbaric oxygen therapy had a substantial positive effect in his life where other treatments had failed.
Patients can also combine Hyperbaric Oxygen Therapy with Regenerative Medicine. Regenerative Medicine is an alternative option to help manage the symptoms of Parkinson’s Disease. The stem cells have the potential to replicate and repair numerous cells of the body, including those damaged by Parkinson’s. These advancements in the treatment of Parkinson’s Disease work to fully regenerate missing or damaged tissue that the body would not ordinarily regrow.
Call your dedicated Care Coordinator at 800-531-0831 for more information.
Reference: Xu, Jin-Jin et al. (2018). Hyperbaric oxygen treatment for Parkinson’s disease with severe depression and anxiety. Medicine. 2018 Mar; 97(9): e0029.
by admin | Mar 22, 2019 | Stem Cell Research, Cannabinoid, Stem Cell Therapy
Over 1 million patients worldwide have been treated with adult stem cells and have benefited from them. And nearly 20 000 adult stem cell transplants were performed in the United States in 2014 alone! How is that possible? What are stem cells? What do they do to your body? And why are so many benefiting from them? We take a look at these important questions surrounding the benefits of stem cells, as well as how CBD can help you get the most benefits from stem cells.
What Are Stem Cells?
Stem cells are a very special kind of human cells. They are cells of the body and are therefore somatic cells, found in your bone marrow and fat cells. They are a part of your body’s natural repair process. But why are they so special? Well, they have the ability to develop into many different cell types. This can range from anything from muscle, cartilage and even bone! Stem cells can divide and become differentiated, and are therefore used as a therapy called stem cell therapy. Stem cell therapy involves using a patient’s own stem cells to repair damaged tissues. When an organism grows, the stem cells specialize and take on specific functions, including skin, nerves, blood, muscle, and liver.
Because of their magical transformative powers, they have the potential to treat a number of diseases, including diabetes, Parkinson’s and even cancer. They also have the potential to treat a number of serious injuries, from a damaged knee, to even treating spinal cord injury! Eventually, they may even be used to regenerate entire organs, decreasing the need for organ transplants. Now that we know what stem cells are and how they work, let’s have a look at five of their biggest benefits.
1. Avoid Invasive Surgery and Related Risks
One of the biggest benefits of stem cells and using them in stem cell therapy is that it allows patients who would possibly have required heavy surgery to not have any such invasive surgery. Stem cell therapy uses material already in the patient’s body, which makes it minimally invasive and also cuts out the need for an overly stressful, invasive surgical procedure. Most stem cell therapy is performed as an outpatient procedure, i.e. you can just have it done in the doctor’s office! No need for an overnight hospital stay and those ridiculously high associated medical costs.
Your doctor will first conduct a bone marrow aspiration, in which he removes stem cells from an area of the body, such as the hipbone, through a long needle. These cells are then delivered to the area of injury. Once there they work their magic to create healthy new tissue to replace a damaged muscle, tendon, ligament, cartilage or bone. They become healthy new cells that your body desperately needs.
2. Minimal Procedure & Recovery Time
One of the greatest stem cell benefits is the minimal amount of time involved in the whole therapy, from the actual procedure to the recovery time required afterward. Procedures generally last from two to five hours, depending on the type of cell treatment being performed. After the minor procedure, your activity level may be a bit limited for the first week. This is merely to let the stem cell therapy process to work uninterrupted and without any possible inflammation. After just seven days you should be able to return to your normal activity! Your treatment will include some monitoring after the treatment, to ensure everything is working as it should.
3. Can Offer Pain Relief
Stem cell therapy is highly sought out by patients who experience chronic pain. As it should be! Because of stem cells’ ability to restore and regenerate, being used in pain management is a logical step. The use of stem cell therapy is being studied for a number of chronic pain conditions, particularly pain in the knees, hips, elbows, and back. Stem cell therapy can offer pain relief in the way that it reduces the inflammation which causes chronic pain. It also helps to heal regenerative conditions that lead to pain, such as arthritis. Promising results have been found in research into the use of stem cells to reduce arthritis pain. As every patient and their condition is different, long-lasting pain relief can never be guaranteed by any doctor.
4. No Risk of Rejection
When you receive stem cells from a donor, there’s always the risk that your body will reject them. Because the stems are coming from another person’s body, many complications can arise. The most common complication is called graft-versus-host disease. This is when blood cells formed from the donor’s stem cells believe your own cells are foreign and attack them. On the other hand, harvesting stem cells extracted from your own body to generate new cells and tissues means there is no risk of rejection!
5. Potential to Discover New Treatments
Because of the nature of stem cells, the possibilities for treating new diseases and finding new cures is endless. Stem cell therapy research provides great potential for discovering treatments and cures to a variety of diseases. Advanced research is going as far as limbs and organs being grown in a lab from stem cells, which are then used in transplants. With stem cells, scientists are able to test millions of potential drugs and medicine, without the use of animal or human testers.
How Can CBD Help with Stem Cell Treatment?
We’ve seen how amazing stem cells are. Now let’s have a look at how much more amazing they can be when combined with the effects of CBD! According to results from multiple trials, cannabidiol, or CBD, can help increase the number of stem cells growing within the body. CBD has even shown to positively contribute to the movement of the stem cells within the body. They can then do what they do best – help heal the body and reduce pain.
Nearly 20% of those who went through hematopoietic stem cell transplant (HSCT) used cannabis. Not only was it used to treat their physical and emotional pain, but it was also used in the hope that it will contribute to the replacement of bone marrow that has been destroyed by cancer. Because both CBD and stem cells have been seen to reduce pain, combined the possibilities for better treatments are endless.
How Can I Experience the Benefits of Stem Cells?
You’ve heard about the many benefits of stem cells. You’ve heard how popular it is. And you’ve heard the vast amount of injuries, diseases, and pain that it can treat. Perhaps it’s about time you had a look at it as a treatment for your condition. Whether you’re looking for an alternative treatment to your sports injury, your multiple sclerosis or your chronic fatigue syndrome, we’re here to help you along the way.
Get in touch with us to see if you are a candidate for Stem Cell Therapy. Also, check out our website shop to see available products.
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