Managing diabetes and its related complications can be challenging, particularly when nerve damage and chronic pain become part of daily life. At Stemedix, we provide access to advanced regenerative approaches that focus on supporting the body’s natural repair mechanisms. Stem cell treatment for diabetes offers a potential way to address issues like nerve injury, inflammation, and tissue damage. By working with you and reviewing your existing medical records, we can develop a tailored plan that aligns with your health profile.
Stem cell solutions for diabetes are being studied for their ability to support insulin-producing cells, reduce inflammatory activity, and promote repair in affected tissues. While these therapies are still considered experimental, they represent a carefully monitored option for patients looking for alternative ways to manage complications such as diabetic neuropathy, impaired circulation, and chronic wounds. With us, you receive guidance through every step of the treatment process.
Understanding Diabetes-Related Nerve and Tissue Damage
Diabetes affects more than just blood sugar levels. Over time, elevated glucose can damage nerves and tissues, creating complications that impact daily life and mobility.
How High Blood Sugar Affects the Nervous System
High blood sugar can damage nerves and small blood vessels. Nerve cells are highly sensitive to changes in glucose levels. Persistently high blood sugar can impair the way nerves send signals, slowing repair and causing discomfort. Patients often experience numbness, tingling, or burning sensations in their hands and feet. Research shows that nearly 50% of individuals with diabetes develop some form of neuropathy over time. High glucose also affects microvessels that supply nerves with oxygen and nutrients. Reduced blood flow can worsen nerve injury and delay natural repair processes.
Common Diabetic Complications Linked to Nerve Injury
Diabetic neuropathy can result in pain, numbness, and organ-related issues. Nerve damage may affect multiple parts of the body:
Peripheral neuropathy: Commonly affects the hands and feet, causing tingling, burning, or loss of sensation.
Autonomic neuropathy: Can disrupt digestion, heart rate, or blood pressure regulation.
Slow wound healing: Reduced sensation and circulation increase the risk of infections and ulcers.
Studies show that patients with peripheral neuropathy are likely to experience foot ulcers compared to those without neuropathy. Chronic nerve injury also increases the likelihood of mobility limitations and decreased daily activity.
What Stem Cell Therapy Means in Diabetes Care
Stem cell therapy is being explored as a way to support the body’s natural repair processes in diabetes. These therapies focus on targeting damaged tissues and supporting overall cellular function.
Stem Cell Therapy for Diabetes – Key Concepts
Stem cell therapy for diabetesintroduces regenerative cells to support tissue health. These cells act by releasing molecules that can assist in repairing nerves, reducing inflammation, and supporting metabolic activity. They do not work alone but interact with your existing cells to create a more supportive environment for tissue repair. This approach is not intended to replace your organs or primary medical care but may complement your current management strategies for diabetes-related complications.
How These Cells Behave in the Body
Stem cells adapt to their environment and communicate with surrounding tissues. They respond to signals from nearby cells and release bioactive factors that influence repair and regeneration. Instead of directly replacing damaged tissues, they provide support to your existing cells, helping improve function in areas affected by diabetic complications.
Stem Cell Solutions for Diabetes: Areas Being Studied
Beta-cell Support and Insulin Regulation
Stem cell solutions for diabetes may support insulin-producing beta cells. This can help maintain blood sugar balance by supporting the cells responsible for producing insulin. Supporting beta-cell function may help reduce the strain on your pancreas over time.
Inflammation Control
Stem cells secrete molecules that reduce inflammation. Chronic inflammation can worsen nerve and tissue damage in diabetes. By modulating inflammatory activity, these cells may help reduce ongoing cellular stress in affected areas.
Tissue Restoration
Stem cells may promote repair of nerves and blood vessels. This can improve function in tissues that have been affected by diabetes-related damage. By supporting both nerve and vascular health, stem cell therapy may help improve mobility, sensation, and overall tissue integrity.
Stemedix provides guidance for patients exploring stem cell therapy for diabetes, reviewing medical records, and helping create personalized therapy plans based on your needs.
Stem Cell Therapy for Diabetic Neuropathy
Diabetic neuropathy can impact daily life in many ways. Nerve damage may cause pain, numbness, or difficulty with coordination, which can make simple tasks challenging.
Why Neuropathy Is a Focus Area
Diabetic neuropathy is common and affects mobility and comfort. Pain, numbness, and reduced sensation make it a primary focus for stem cell therapy for diabetic neuropathy. Addressing nerve injury can help you regain movement and reduce discomfort. Targeted regenerative therapies focus on supporting damaged nerves and surrounding tissues, giving your body the resources it may need to function more effectively.
Biological Actions Being Investigated
Nerve Protection
Stem cells may support the integrity of damaged nerves. These cells interact with local tissues to encourage repair, which may help prevent further degeneration and maintain nerve signaling. Supporting nerve health can lead to improvements in sensation and reduce the impact of neuropathy on daily life.
Vascular Support
Stem cells may improve circulation in small blood vessels. Healthy blood flow helps maintain tissue function and supplies nutrients needed for nerve repair. Improved circulation may also help reduce discomfort and swelling associated with nerve damage.
Reduced Inflammatory Activity
Stem cells release factors that modulate immune activity. Reducing inflammation may slow further nerve injury and support a more favorable environment for tissue repair. Less inflammation can help improve overall nerve function and comfort.
Patient-Reported Outcomes Seen in Clinical Settings
Patients report improvements in energy, nerve discomfort, and daily activity. Some common experiences include:
Reduced tingling or burning sensations in hands and feet
Improved walking, balance, and coordination
Enhanced ability to perform daily activities
Emerging Applications for Other Diabetes-Related Complications
Diabetes affects more than just blood sugar levels. You may notice its impact on circulation, kidney function, and joint or muscle health, which can make daily activities more difficult. Stem cell therapies are being studied for their potential to support these areas.
Wound Healing and Circulation Support
Stem cell treatment for diabetes may support chronic wound repair. Slow-healing wounds are common in people with diabetes. Stem cells release molecules that can encourage tissue repair and improve blood flow. This may reduce the risk of infections and help maintain skin integrity.
Supports repair of small skin injuries and ulcers
Improves circulation in areas affected by poor blood flow
Promotes tissue regeneration through cellular signaling
Kidney Stress and Tissue Injury
Stem cells may help support kidney tissue affected by diabetes. Diabetes can place stress on kidney structures, leading to inflammation and gradual tissue damage. Stem cells can release factors that may help reduce inflammation and encourage repair of affected areas.
Supports kidney tissue integrity
Modulates inflammatory activity in kidney cells
May help reduce progression of tissue damage
Joint and Muscle Pain Linked to Diabetic Changes
Stem cells may support joint and muscle health. Many patients notice stiffness, soreness, or reduced mobility due to changes in muscle and connective tissues. Stem cell therapy may aid in controlling inflammation and supporting tissue recovery, which can help improve comfort and movement.
Reduces inflammatory activity in muscles and joints
Supports repair of connective tissues
Can improve day-to-day mobility and comfort
Why Many Patients Seek Help From Stemedix
Patients exploring regenerative medicine want a clear, patient-focused approach. This section highlights the support and guidance you receive throughout the process.
Regenerative Medicine Expertise
Stemedix focuses exclusively on regenerative medicine therapies. Our team applies research-backed methods to design treatments tailored to your specific condition. Every plan looks at your medical history, current test results, and personal needs to provide care that is precise and organized. You can expect a treatment path that is structured and guided by specialists familiar with the latest developments in stem cell applications for diabetes and related complications.
Board-Certified Providers
All therapies are approved by specialized, board-certified physicians. Each provider reviews your existing medical records and lab results to determine the most suitable therapy options. Our focus is on supporting your health through carefully considered regenerative approaches rather than offering new diagnoses.
Step-by-Step Coordination and Travel Assistance
Patients receive dedicated guidance throughout their journey. Care coordinators schedule appointments, help manage ground transportation, and assist with mobility aids such as wheelchairs or walkers if needed. This support allows you to focus on the treatment itself rather than logistical challenges.
Conditions Already Diagnosed by Each Patient’s Own Doctor
Stemedix treats pre-diagnosed conditions. The therapies offered are based solely on information provided by your own physician. Your treatment plan is built around existing medical records, ensuring that the therapy complements the care you are already receiving.
Take the Next Step with Stemedix
If you are exploring stem cell treatment for diabetes or related complications, Stemedix can guide you through the process. Our team works with you to review medical records, discuss potential therapy plans, and provide support every step of the way. To learn more or request information, contact us at (727) 456-8968 or email yourjourney@stemedix.com. Our staff is ready to answer your questions and help you begin the process of personalized regenerative care.
Amyotrophic lateral sclerosis or ALS is a neurological disease that causes muscle weakness, profound disability, and ultimately death. ALS is sometimes referred to as Lou Gehrig’s disease, named for the New York Yankee baseball player who developed the condition later in his life. Notably, physicist Stephen Hawking long suffered from the condition.
ALS affects the nerves that control movement. As nerve cells become dysfunctional and die, a person’s muscles become weak. The disease often starts with weakness in one part of the body before moving to other parts. In 4 out of 5 people with ALS, the first symptom is a weakness of one limb but not the other. Over time, however, the disease spreads to virtually all motor neurons (nerve cells) in the body. Eventually, patients are unable to walk because of muscle weakness and are usually confined to a wheelchair. The condition becomes particularly difficult to manage and potentially life-threatening when it starts to affect lung muscles, which make it hard for patients with ALS to breathe.
There is no cure for amyotrophic lateral sclerosis. For the most part, however, treatment for ALS focuses on reducing the symptoms of the condition rather than treating it. Patients often undergo intensive physical, occupational, and speech therapy regimens to help manage symptoms of ALS. Physicians may prescribe drugs to reduce muscle spasms, sleep problems, and pain associated with the condition. Researchers are constantly looking for ways to improve ALS treatment.
Dr. Petrou and co-authors recently reported clinical trial results in the highly regarded medical journal, JAMA Neurology. The researchers started their research by altering mesenchymal stem cells in the laboratory so that they produce neurotrophic growth factors. In other words, they engineered stem cells to release substances that help nerve cells grow and survive. Then they tested these stem cells in two clinical trials. In the first clinical trial, the doctors used these stem cells to treat six patients with early-stage ALS and six patients with advanced ALS. In the second clinical trial, they tested the stem cells in 14 patients with early-stage ALS.
All patients in both trials tolerated the stem cell treatments very well. There were no serious side effects related to treatment. 87% of the patients responded positively to treatment, which means they showed at least 25% improvement in physical function and/or lung function. These positive results from stem cell treatment are particularly impressive because ALS gets worse over time. Patients generally either stay the same or get worse—it is quite unusual for them to get better. Encouraged by these results, the researchers who worked on this study will now confirm these results in larger clinical trials. The hope is that this stem cell treatment will be available for patients with ALS in the coming years.
Reference: Petrou P. et al. (2016).Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials. JAMA Neurology.2016 Mar;73(3):337-44.
Amyotrophic lateral sclerosis (ALS) is an incurable neurologic disorder that causes muscle weakness, and disability. In ALS, nerve cells degenerate causing muscle weakness and atrophy. ALS affects the nerve cells that connect the brain to the spinal cord (upper motor neurons), and nerve cells that connect the spinal cord to muscles (lower motor neurons). While some patients with ALS will experience paresthesias (numbness and tingling), most nerves that detect sensations remain intact until the very latest stages of the disease. Over time, people with ALS may experience cognitive problems such as mild dementia, though most stay mentally sharp. Patients with ALS may also experience Parkinson’s-like symptoms, such as tremor and slowness of movement (bradykinesia). When the nerves that control swallowing or breathing become dysfunctional, ALS can become life-threatening or lethal. Damage to these nerves and muscles could lead to aspiration pneumonia, and respiratory failure, respectively.
ALS is also known as Lou Gehrig’s disease because the famed New York Yankee publicly struggled with ALS. Perhaps people alive today are more familiar with another patient who suffered from ALS, the Nobel laureate physicist, Stephen Hawking. Dr. Hawking was well known for being confined to a wheelchair and almost completely paralyzed, requiring a specialized computer interface to communicate.
There is no specific treatment for ALS. Therapy is aimed at controlling the symptoms of the disease. For example, patients may have a breathing tube placed in their neck (tracheostomy) and be connected to a ventilator to help support breathing. Likewise, a feeding tube in the stomach can help patients receive hydration and nutrition if they cannot safely swallow food because of neck muscle weakness. Physical therapists help patients maximize the strength and function. Certain medicines can be used to help treat muscle spasms, sleep problems, pain, and depression.
Since there is no cure for ALS, and really no specific treatment for the condition, there is considerable interest in discovering effective treatments. One of the most promising potential therapies is to use stem cells to treat ALS. Since ALS is caused by the destruction and loss of motor neurons, a reasonable treatment approach is to use stem cells that can become motor neurons and promote motor neuron growth and development.
Recently, researchers conducted two clinical trials to evaluate the safety and feasibility of using bone marrow-derived mesenchymal stromal cells to treat patients with ALS. In one clinical trial, the researchers infused stem cells intravenously, while in the other they infused the stem cells into the cerebrospinal fluid around the spine (intrathecally). Patients in both trials were followed for up to 12 months after the infusion to see if the stem cells caused side effects. During the follow-up period, there were no reports of adverse events related to the treatment. Given the success of these trials, this work clears the way for future clinical trials to study the efficacy of stem cells for treating amyotrophic lateral sclerosis.
Reference: Nabavi et al. (2019). Safety, Feasibility of Intravenous and Intrathecal Injection of Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: An Open-Label Phase I Clinical Trial. Cell Journal. 2019 Jan;20(4):592-598.
Of all conditions that affect the central nervous system, Multiple Sclerosis (MS) is the most common in young adults. The severity of multiple sclerosis varies considerably and can affect almost every organ system in the body affecting eyesight, bowel function, bladder function, and sexual function. Multiple sclerosis may cause cognitive problems, depression, seizures, fatigue, and pain. Most people with multiple sclerosis will have a relapsing-remitting course, which means they will have periods of relative health punctuated by flare-ups of the condition. About one out of ten people with the condition will have primary progressive multiple sclerosis, which means once the disease occurs it almost constantly causes symptoms and progresses over time.
Multiple sclerosis appears to be an inflammatory condition that affects the covering around nerves. During acute flareups/exacerbations, physicians usually prescribe a powerful steroid medication such as methylprednisolone to combat the inflammation. Patients with multiple sclerosis generally always require some sort of treatment to help manage their immune system. No fewer than 15 immune modulating treatments have been used to treat multiple sclerosis, none of which provides a cure. As such, researchers are seeking new and innovative ways to treat this potentially debilitating condition.
Researchers at the Tisch Multiple Sclerosis Research Center of New York chose to focus their research efforts on a particular type of stem cell, namely bone marrow-derived mesenchymal stromal cells. The researchers harvested these cells from the patients themselves (autologous stem cells). Then, in their laboratory, scientists used various means to prompt the cells to become neural progenitors. A neural progenitor cell is a cell that can become any of the three main types of brain cells: neurons, astrocytes, or oligodendrocytes. Incidentally, oligodendrocytes are believed to be most affected in multiple sclerosis.
Harris and co-authors at the Tisch Center enrolled six patients with progressive multiple sclerosis. These six patients had failed to find relief from other conventional multiple sclerosis treatments. The researchers provided between 2 to 5 infusions of neural progenitor cells into the spinal fluid. The multiple sclerosis patients treated with the cells tolerated the treatment very well. No serious adverse events occurred, nor were there any safety concerns during treatment. Impressively, four of the six patients—for whom no other multiple sclerosis treatment worked—had a measurable clinical improvement after stem cell treatment.
Based on the results of this clinical study, the scientists concluded that neural progenitor cells created from autologous mesenchymal stromal cells were safe to use in patients with primary progressive multiple sclerosis. Moreover, the beneficial effect witnessed in two-thirds of treated patients suggests that these cells may be able to help patients with even the most severe and difficult-to-treat forms of multiple sclerosis. Of course, additional testing is required before this treatment becomes commonplace, but the results of this first-in-human clinical study are extremely encouraging.
Reference: Harris et al. (2016). Clinical safety of intrathecal administration of mesenchymal stromal cell-derived neural progenitors in multiple sclerosis. Cytotherapy. 2016 Dec;18(12):1476-1482.
Cartilage plays several important roles in the way joints move and function. Joint cartilage provides lubrication, acts as a shock absorber, and helps the joint move smoothly. Joint cartilage is comprised of two substances chondrocytes (i.e. cartilage cells) and extracellular matrix (proteins such as hyaluronic acid, collagen, fibronectin, etc.).
Many conditions can lead to joint cartilage defects. In young people, the most common cause of the joint cartilage defect is an injury. For instance, a football player suffers a hard contact that injures the joint. Another example is a gymnast who repeatedly places substantial impact forces on the knee and other joints of the lower body, resulting in damage. In older people, the most common cause of joint cartilage defects is Osteoarthritis. Over time, the joint cartilage breaks down in the cartilage loses its ability to lubricate, absorb shock, and support the smooth movement of the joint. This leads to stiffness, pain, and “trick” joints, among other symptoms.
Orthopedic surgeons, rheumatologists, and other physicians have attempted to treat these conditions by injecting the damaged joint with one of the two main components of joint cartilage: extracellular matrix. Physicians inject hyaluronic acid (and sometimes related extracellular matrix proteins) to help replace and restore damaged joints. This approach can be helpful for some patients, but it is certainly not a cure.
Only recently, have researchers attempted to replace the other component of joint cartilage: chondrocytes. Specifically, researchers have focused their efforts on mesenchymal stem cells that have the ability to differentiate and become cartilage cells. Li and colleagues injected combinations of bone marrow-derived mesenchymal stem cells and hyaluronic acid into animals with experimental cartilage defects. They showed that hyaluronic acid injections alone modestly repaired the cartilage damage. However, when stem cells plus hyaluronic acid was injected, the joints were almost completely repaired. In other words, stem cells plus hyaluronic acid resulted in much greater improvement in joint cartilage damage than hyaluronic acid alone.
The authors of the study concluded that “bone marrow stem cells plus hyaluronic acid could be a better way to repair cartilage defects.” While additional work is needed, these results are extremely exciting for people who suffer from joint cartilage defects such as osteoarthritis. In the future, people who are candidates for hyaluronic acid injection treatments may instead receive a combination of hyaluronic acid plus stem cells and may enjoy an even greater benefit than hyaluronic acid treatment alone.
Reference: Li et al. (2018). Mesenchymal Stem Cells in Combination with Hyaluronic Acid for Articular Cartilage Defects. Scientific Reports. 2018; 8: 9900.
This website and its contents are not intended to treat, cure, diagnose, or prevent any disease. Stemedix, Inc. shall not be held liable for the medical claims made by patient testimonials or videos. They are not to be viewed as a guarantee for each individual. The efficacy for some products presented have not been confirmed by the Food and Drug Administration (FDA).
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