by admin | Jan 7, 2022 | Stem Cell Therapy, Kidney Disease, Mesenchymal Stem Cells, Stem Cell Research
Current estimates indicate that kidney disease currently affects over 37 million US adults and over 10% of the global population[1]. Characterized by gradual loss of function, kidney disease generally progresses over time and culminates in the inability to remove waste and excess fluid from the blood[2].
Often demonstrating little to no symptoms in its early stages, chronic kidney disease tends to demonstrate increasing and dangerous symptoms as the condition advances.
To date, treatment for chronic kidney disease has been centered around causal control as a way of slowing the progression of the condition. However, these therapeutic treatment efforts, including multidrug therapy, have demonstrated an inability to reverse the condition from progressing to end-stage renal disease (ESRD) and requiring additional therapy, dialysis, or kidney transplantation.
Considering the high cost and disruption to normal life function associated with dialysis and the severe shortage of viable kidney donors, neither dialysis nor transplant has proven to be ideal or often recommended treatment strategies. As a result, there has been renewed interest in new and more effective therapeutic options to alleviate, cure, or prevent kidney disease and to improve a patient’s survival and quality of life.
Evaluating the numerous and growing therapeutic applications associated with stem cells’ ability for self-renewal, proliferation, and differentiation, Liu et al.’s review explores the potential benefits offered toward improving renal function and supporting structural repair in those afflicted with kidney disease.
Despite the promising benefits of using stem cells to kidney repair and disease treatment demonstrated through prior preclinical study, the authors point out that certain ethical issues regarding the origin of stem cells, and specifically embryonic stem cells (ESCs) need to be addressed and overcome before clinical application of SCs.
Regardless of the stated drawbacks, Liu et. al concludes that the existing evidence demonstrates that stem cell therapy appears to be a clinically viable alternative for kidney disease, specifically for restoring normal kidney function and for progressing understanding about tissue regeneration, drug screening, and disease modeling.
Although stem cells demonstrate promise in this regard and while the immunomodulatory properties of mesenchymal stem cells (MSCs) appear to make them the most promising SC for treating kidney disease, the authors also point out that further research is needed before definitively concluding which source of SC is best suited for this application.
As a result of this review, and in an effort to realize these findings into clinical applications in the future, the authors call for larger rigorously designed clinical trials to further assist in determining the clinical efficacy of SC therapy in kidney disease – including the appropriate selection of cell types, number of SCs required, and the appropriate route of administration.
Source: “Stem cells: a potential treatment option for kidney diseases.” 25 Jun. 2020, https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01751-2.
[1] “Chronic Kidney Disease Basics – CDC.” https://www.cdc.gov/kidneydisease/basics.html.
[2] “Chronic kidney disease – Symptoms and causes – Mayo Clinic.” 3 Sep. 2021, https://www.mayoclinic.org/diseases-conditions/chronic-kidney-disease/symptoms-causes/syc-20354521.
by Shoot To Thrill Media | Dec 30, 2021
WHAT IS Regenerative Medicine for Inflammatory Bowel Disease? For those seeking to potentially manage symptoms of this condition, Regenerative Medicine, also know as Stem Cell Therapy, for Inflammatory Bowel Disease may be a natural alternative option. Request...
by Stemedix | Dec 20, 2021 | Heart Failure, Stroke
Hopefully, you will never experience a stroke or a heart attack, but it is important to know the differences between these two potentially fatal medical emergencies. The most important similarity may be that if you or someone you know is showing the symptoms of a stroke or a heart attack, time is crucial. Getting immediate medical help increases the chance of survival and recovery.
Heart Attacks Explained
Heart disease is the number one cause of death in the U.S. Heart disease can lead to a heart attack, also known as a myocardial infarction.
The term “heart attack” refers to damage of the heart muscle, usually caused by a lack of blood flow. If a blood clot forms in one of the arteries that supply blood to the heart, it can block blood flow and deprive the heart of the nutrients it needs to function.
As the heart weakens from lack of nourishment, chest pain and other symptoms may occur. Warning signs of a heart attack include:
- Fatigue
- A sense of impending doom
- Nausea
- Sweating
- Pain radiating down the left arm
- Shortness of breath
- Feeling lightheaded
- Pain or numbness in the upper body
- Stomach pain
- Changes in heartbeat
- A bluish tint to the hands, feet, or lips
- Pain in the jaw or between the shoulder blades
Men and women tend to experience a different set of symptoms; however, warning signs can be different for every person. In some cases, there is no warning at all. This is referred to as a “silent heart attack.”
Stroke Explained
Like heart attacks, strokes are usually caused by a blood clot that blocks blood flow in the arteries. In this case, the blockage affects the brain. Deprived of nourishment, a section of the brain dies, resulting in a stroke.
There are three types of strokes. Ischemic stroke is caused by a blood clot, and it is the most common type. Bleeding in the brain, usually from injury or aneurysm, may cause a hemorrhagic stroke. A transient ischemic attack is caused when an artery that feeds the brain is restricted but not blocked.
Warning signs of stroke are typically less painful and more subtle than warning signs of a heart attack. They may include:
- Dizziness
- Speech difficulties
- Arm or leg weakness
- Confusion
- Vision loss
- Facial drooping
- Tingling or numbness in extremities
- Sudden incontinence
The chances of surviving and recovering from a stroke depend on what part and how much of the brain was affected. Immediate medical help increases the chance for recovery.
Stroke and heart attack are both age-related health problems. Longer life spans mean the conditions have become more common. Unfortunately, many patients still end up with some type of long-term disability.
The Future of Regenerative Medicine
There is hope that regenerative medicine, also known as stem cell therapy, may offer an option to help repair the damage caused by a stroke or heart attack. As medicine continues to advance, the damages of these serious conditions may become less permanent. Patients are exploring the beneficial opportunities that stem cells hold. If you would like to learn more contact a care coordinator today!
by admin | Dec 3, 2021 | Adipose, Mesenchymal Stem Cells, PRP, Stem Cell Research, Stem Cell Therapy
Osteoarthritis is the most common form of arthritis, affecting more than 900 million people around the world. Developing when the cartilage that protects your bones wears down, osteoarthritis (OA) most commonly affects the joints of the hand, hips, spine, and knees[1].
While current treatment for OA and related joint damage is focused primarily on managing pain and minimizing further damage, function, and quality of life issues, no preventative therapeutic treatment currently exists for preventing or rehabilitating the condition.
Recently, stem cell therapy has been found to be an efficient therapeutic approach for treating degenerative joint conditions, including OA. Specifically, mesenchymal stem cells (MSCs), from adipose cells have been demonstrated to be the most promising type of stem cell for treating osteoarthritis.
In this study, Bui et al. studied the outcomes of applying MSCs harvested from adipose tissue in an effort to evaluate the therapeutic potential when transplanted in patients with grade II and III osteoarthritis.
Building on the findings of previously published studies, the authors specifically evaluated the in vitro and animal model effects of platelet-rich plasma (PRP) on the differentiation of adipose-derived stem cells (ADSC).
Previous studies have demonstrated that PRP treatment of ADSCs promotes differentiation and proliferation into chondrogenic cells which resulted in improved healing of articular cartilage when ADSCs were pretreated with PRP. An additional study demonstrated the effects of PRP on the non-expanded stromal vascular fraction (SVF) in cartilage injury observed in an animal model, demonstrating significant regeneration of cartilage.
The aim of this clinical trial was to evaluate the efficiency and related side effects of non-expanded SVF when combined with PRP in treating OA grade II or III.
At the conclusion of Bui et al.’s study, patients demonstrated significant improvements in key measures, including improved joint function, decreased pain score, and improved gradual and consistent improvement observed in pre and post observations as measured by the Lysholm score.
As further evidence of the success associated with a therapeutic treatment combination of ADSC and PRP, post-treatment MRIs demonstrated cartilage regeneration and thicker layers of cartilage at the injured site after 6 months of treatment. In addition, all participating patients reported reduced pain levels after 3 months and 71% of patients demonstrated the ability to climb and descend stairs after 3 months. None of the patients participating in this study demonstrated infection, tumor formation, or any other side effect or complication as a result of this procedure.
As a result of their findings in this study, Bui et al. conclude that this therapeutic treatment method was successful in reducing pain, regenerating cartilage, and improving the quality of life for patients who participated. However, considering the small size of this study, the authors call for additional and larger-scale studies to confirm the potential for this promising, minimally invasive stem cell therapy for patients with osteoporosis.
Source: “Symptomatic knee osteoarthritis treatment using autologous adipose ….” 5 Oct. 2016, http://www.bmrat.org/index.php/BMRAT/article/view/11.
[1] “Osteoarthritis – Symptoms and causes – Mayo Clinic.” 16 Jun. 2021, https://www.mayoclinic.org/diseases-conditions/osteoarthritis/symptoms-causes/syc-20351925.
by Stemedix | Nov 29, 2021 | Uncategorized
As one of the most common neurological conditions worldwide, multiple sclerosis plays a big part in over two million people’s daily lives. Since it is so prevalent, there is currently a lot of ongoing research into preventing and treating MS. Many people already diagnosed wonder whether there is a diet that can cure or slow the progression of MS.
What Is MS?
Multiple sclerosis (MS) is an autoimmune disease characterized by the degeneration of the myelin sheaths protecting nerve fibers in the brain. However, MS and its progression vary significantly from person to person and affect some people much more than others.
Some people may experience a small, controlled lesion that does not affect cognitive or physical functions. In contrast, others may have multiple lesions across their brain or spine and experience significant cognitive and physical disabilities.
Can the Right Diet Cure MS?
There is not a diet or treatment available that can cure MS. People who claim to know secret eating habits that will cure this chronic condition are promoting non-science-backed products. But luckily, making healthy dietary choices may help lessen your symptoms.
The diet recommended for MS patients is the same that’s recommended for the average adult. A well-balanced diet with lots of fruits, vegetables, whole grains, and little saturated fat is ideal. For people with MS, healthy eating can help overall management of the condition, potentially slow the progression of the disease, and improve quality of life.
What to Avoid
There tends to be a lot of confusion about what lifestyle habits people with MS should avoid. Things MS patients should avoid include the following:
- Smoking
- Drinking
- Skipping meals
- Eating lots of processed foods
- Not exercising regularly
Some recommendations say to avoid dairy, and others say to avoid gluten at all costs if you have MS. Neither of these suggestions is significantly backed by scientific research. People with MS may be lactose intolerant or gluten intolerant. However, if you aren’t, there’s no reason to avoid these products as they have no impact on the progression of MS. One study showed a relation to Vitamin D deficiency and those with MS.
Other Ways You Can Manage Your MS
MS symptoms can become more manageable with the help of medications, lifestyle adjustments, and emerging experimental therapies. One such alternative treatment that may help manage MS symptoms is stem cell therapy. This approach has the ability, through the science of mesenchymal stem cells, to restore damaged myelin sheaths and prevent further progression.
Stem cell therapy has shown promising results in research and will continue to undergo extensive studies in the coming years. Patients may want to explore more to see if it is something that they may have a potential benefit from this alternative therapy. If you are interested in learning more contact a care coordinator today!
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