Human Mesenchymal Stem Cells (hMSCs) are the non-hematopoietic, multipotent stem cells with the capacity to differentiate into mesodermal lineages such as osteocytes, adipocytes, and chondrocytes as well ectodermal (neurocytes) and endodermal lineages (hepatocytes).
Until recently, when the immunomodulation properties of MSCs were proven to be clinically relevant, the use of these stem cells was met with skepticism and doubt by a large portion of the scientific community.
However, since that time, MSCs have demonstrated tremendous potential for allogeneic use in a number of applications, including cell replacement, and tissue regeneration, and for use in the therapeutic treatment of immune- and inflammation-mediated diseases. In fact, in many cases, the use of MSCs has been so successful that they appear to demonstrate more efficacy than what has been observed previously in traditional regenerative medicine.
Among the many benefits making MSCs so interesting for this application is their capacity for both multilineage differentiation and immunomodulation. Obtaining a better understanding of these capacities has opened new doors in regenerative medicine and demonstrated that these somatic progenitor cells are highly versatile for a wide range of therapeutic applications.
Additionally, the authors of this review point to research indicating the capacity of MSCs to home to the site of injury and/or inflammation, making them more attractive for use in clinical application. In this review, Wang et al. focus on this non-traditional clinical use of tissue-specific stem cells and highlight important findings and trends in this exciting area of stem cell therapy.
At the time this review was published, there were over 500 MSCs-related studies registered with the NIH Clinical Trial Database. Interestingly, nearly half of these trials involve attempts to better understand the use of MSCs in treating immune- and inflammation-mediated diseases – an indication of the recent shift in focus when determining effective therapeutic applications of MSCs.
In reviewing these clinical trials, Wang et al. found that the most common immune-/inflammation-mediated indications in MSC clinical trials were for graft-versus-host disease (GVHD), osteoarthritis (OA), obstructive airway disease, multiple sclerosis (MS), and solid organ transplant rejection.
Clinical trials involving MSCs, and specifically HSCs, in GVHD have indicated that while there may be indications of immunosuppressant therapy, immune rejection in the form of GVHD is still a major cause of morbidity and mortality, occurring in 30 ~ 40 % of allogeneic HSC transplantations.
Despite a number of clinical trials indicating significant efficacy in the use of MSCs for GVHD treatment, the authors point out that these findings were not observed consistently throughout all trials. Significant differences in these studies appeared to be related to differences in adult and pediatric applications, a specific type of HSC that was transplanted, and the type of MSCs that were utilized. There also appears to be a disparity in the results obtained from similar studies conducted in Europe and North America. Considering this, there are a number of studies involving MSCs and GVHD still ongoing.
These findings led the authors to conclude that despite the strong potential of MSCs as therapeutic agents for GVHD, detailed tailoring of the patient population and stringent MSC processing criteria are necessary to deliver consistent and reproducible results.
Despite the mixed findings for use of MSCs in the treatment of GVHD, trials reviewed for other immune/inflammation-mediated diseases, including MS, inflammatory bowel disease, OA, RA, and inflammatory airway and pulmonary diseases demonstrated positive results pertaining to the safety of MSC therapy when used in this application.
Specifically, Wang et al. point out that although there have been positive results observed in preclinical animal studies, these results have not translated to clinical efficacy. In considering this, the authors suggest a focus on better clarifying pathophysiological details and subsets within disease entities to better tailor MSC therapy and standardization of in vitro culture protocols with stringent criteria for testing of functional parameters as two important steps to improve our understanding on the mechanistic properties of MSC immunomodulation.
Despite these recommendations, the authors conclude that the current results and developments of these clinical trials demonstrate that the tremendous potential of MSC therapy in a wide range of areas, including the treatment of immune/inflammation-mediated diseases, can be expected in the near future to achieve clinical relevance. Source: “Human mesenchymal stem cells (MSCs) for treatment towards ….” 4 Nov. 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095977/.
Multiple system atrophy (MSA) is a rare, degenerative adult-onset neurological disorder that affects your body’s involuntary functions, including blood pressure, breathing, bladder function, and motor control. MSA also demonstrates several symptoms similar to those accompanying Parkinson’s disease, including slow movement, stiff muscles, and loss of balance[1].
Considering the rapid and fatal progression of MSA, there are not currently any long-term drug treatments known to produce therapeutic benefits against the condition. The typical neuropathological hallmarks of MSA are bone marrow destruction and cell loss in the striatonigral region of the brain that results in dopamine deficiency significant enough to result in behavioral abnormalities.
Since mesenchymal stem cells (MSCs) have demonstrated the ability to self-renew and differentiate within a wide variety of tissues, Park et al., in this study, aimed to assess whether the transplantation of human-derived MSCs could have beneficial effects in a double-toxin-induced MSA rat model. Additionally, the authors assessed the signaling-based mechanisms underlying the neuroprotective effects of MSCs.
Specifically, as part of this study, Park et al. studied the effects of MSCs in 60 rats randomly allocated to one of six groups – a control group, a double-toxin group, two groups receiving MSC intra-arterial (IA) injections, and two groups receiving MSC transplantation via intrathecal (IT) injection after double-toxin induction.
After receiving treatment each group of rats underwent a variety of tests, including the Rotarod test, gait test, and grip strength test. Additionally, the brain tissue of the rats was collected, preserved, and evaluated to assess notable differences.
At the conclusion of this study, the authors found clear evidence of the protective effects of MSCs on double-toxin-induced MSA. The study also demonstrated that transplantation of MSCs prevented neuronal cell death and improved behavioral disorders caused by double-toxin-induced MSA, specifically by reducing dopaminergic neurodegeneration and neuroinflammation.
Additionally, Park et al.’s study demonstrated a higher expression of polyamine modulating factor-binding protein 1 and a lower expression of 3-hydroxymethyl-3-methylglutaryl-COA lyase (HMGCL) after MSC transplantation.
Park et al. also point out that further investigation is required to better understand the exact mechanism of neuron-specific knockdown in vivo animal and clinical trials.
The authors of this study conclude that treating MSA with bone-marrow-derived MSCs protects against neuronal loss by reducing polyamine- and cholesterol-induced neural damage and may represent a promising new therapeutic treatment option for MSA.
For decades, autoimmune diseases such as Lupus, Rheumatoid Arthritis, and chronic obstructive pulmonary disease (COPD) have posed a major challenge to researchers and healthcare providers. While medical interventions have evolved tremendously in the last few decades, these serious conditions remain notoriously difficult to treat. Here we talk about Stem Cell for Autoimmune Diseases, Specifically Mesenchymal stem cells!
Fortunately, mesenchymal stem cells may be a potentially effective treatment option for many patients suffering from various autoimmune conditions. While the efficacy of this intervention varies depending on unique patient factors, individuals who have had little to no success with traditional interventions may find it useful to consider MSC therapy.
What Are MSCs?
Mesenchymal stem cells are a special type of cell that can transform into other types of cells. MSCs can become specialized cells such as those that form muscular tissue, cartilage, and many others. MSCs can be harvested from many different locations, including bone marrow, adipose (fat) tissue, and the Wharton’s Jelly within umbilical cords.
Once harvested, MSCs can be administered to help manage various conditions and their symptoms. MSCs are typically administered through a systemic application into the blood system. However, they can also be directly administered to have a more targeted impact on a specific area depending on the patient’s case.
Can MSCs Be Used to Treat Autoimmune Diseases?
While MSCs are still being studied, research has indicated that MSCs can be an effective intervention for many different autoimmune conditions, including COPD.
Specifically, mesenchymal stem cells have been effective at treating chronic inflammation, which is a common symptom in many autoimmune patients.
However, every case and patient is unique. Therefore, treatment decisions should be made with the guidance of a licensed medical professional. An experienced care provider can thoroughly review your medical history and condition to help you select the best treatment plan for your needs.
Potential Benefits of Stem Cell for Autoimmune Diseases MSCs
Mesenchymal stem cells have the unique potential to reduce inflammation in individuals suffering from an autoimmune disease, such as Lupus or Rheumatoid Arthritis. There is a correlation between a reduction in inflammation and improvements in other disease symptoms. However, the strength of this correlation is still being researched.
With that being said, MSCs may reduce the severity of many common autoimmune symptoms, including pain and fatigue.
Although research is still in progress, mesenchymal stem cell therapy has shown promise for patients looking for an alternative option. With new advancements in medical tools and therapeutic methodologies, patients who suffer from autoimmune disorders may soon have more options for relief than ever before. If you are interested in learning more about Stem Cell for Autoimmune Diseases, contact us today and speak with a care coordinator!
Managing diabetes and its related complications can be challenging, particularly when nerve damage and chronic pain become part of daily life. At Stemedix, we provide access to advanced regenerative approaches that focus on supporting the body’s natural repair mechanisms. Stem cell treatment for diabetes offers a potential way to address issues like nerve injury, inflammation, and tissue damage. By working with you and reviewing your existing medical records, we can develop a tailored plan that aligns with your health profile.
Stem cell solutions for diabetes are being studied for their ability to support insulin-producing cells, reduce inflammatory activity, and promote repair in affected tissues. While these therapies are still considered experimental, they represent a carefully monitored option for patients looking for alternative ways to manage complications such as diabetic neuropathy, impaired circulation, and chronic wounds. With us, you receive guidance through every step of the treatment process.
Understanding Diabetes-Related Nerve and Tissue Damage
Diabetes affects more than just blood sugar levels. Over time, elevated glucose can damage nerves and tissues, creating complications that impact daily life and mobility.
How High Blood Sugar Affects the Nervous System
High blood sugar can damage nerves and small blood vessels. Nerve cells are highly sensitive to changes in glucose levels. Persistently high blood sugar can impair the way nerves send signals, slowing repair and causing discomfort. Patients often experience numbness, tingling, or burning sensations in their hands and feet. Research shows that nearly 50% of individuals with diabetes develop some form of neuropathy over time. High glucose also affects microvessels that supply nerves with oxygen and nutrients. Reduced blood flow can worsen nerve injury and delay natural repair processes.
Common Diabetic Complications Linked to Nerve Injury
Diabetic neuropathy can result in pain, numbness, and organ-related issues. Nerve damage may affect multiple parts of the body:
Peripheral neuropathy: Commonly affects the hands and feet, causing tingling, burning, or loss of sensation.
Autonomic neuropathy: Can disrupt digestion, heart rate, or blood pressure regulation.
Slow wound healing: Reduced sensation and circulation increase the risk of infections and ulcers.
Studies show that patients with peripheral neuropathy are likely to experience foot ulcers compared to those without neuropathy. Chronic nerve injury also increases the likelihood of mobility limitations and decreased daily activity.
What Stem Cell Therapy Means in Diabetes Care
Stem cell therapy is being explored as a way to support the body’s natural repair processes in diabetes. These therapies focus on targeting damaged tissues and supporting overall cellular function.
Stem Cell Therapy for Diabetes – Key Concepts
Stem cell therapy for diabetesintroduces regenerative cells to support tissue health. These cells act by releasing molecules that can assist in repairing nerves, reducing inflammation, and supporting metabolic activity. They do not work alone but interact with your existing cells to create a more supportive environment for tissue repair. This approach is not intended to replace your organs or primary medical care but may complement your current management strategies for diabetes-related complications.
How These Cells Behave in the Body
Stem cells adapt to their environment and communicate with surrounding tissues. They respond to signals from nearby cells and release bioactive factors that influence repair and regeneration. Instead of directly replacing damaged tissues, they provide support to your existing cells, helping improve function in areas affected by diabetic complications.
Stem Cell Solutions for Diabetes: Areas Being Studied
Beta-cell Support and Insulin Regulation
Stem cell solutions for diabetes may support insulin-producing beta cells. This can help maintain blood sugar balance by supporting the cells responsible for producing insulin. Supporting beta-cell function may help reduce the strain on your pancreas over time.
Inflammation Control
Stem cells secrete molecules that reduce inflammation. Chronic inflammation can worsen nerve and tissue damage in diabetes. By modulating inflammatory activity, these cells may help reduce ongoing cellular stress in affected areas.
Tissue Restoration
Stem cells may promote repair of nerves and blood vessels. This can improve function in tissues that have been affected by diabetes-related damage. By supporting both nerve and vascular health, stem cell therapy may help improve mobility, sensation, and overall tissue integrity.
Stemedix provides guidance for patients exploring stem cell therapy for diabetes, reviewing medical records, and helping create personalized therapy plans based on your needs.
Stem Cell Therapy for Diabetic Neuropathy
Diabetic neuropathy can impact daily life in many ways. Nerve damage may cause pain, numbness, or difficulty with coordination, which can make simple tasks challenging.
Why Neuropathy Is a Focus Area
Diabetic neuropathy is common and affects mobility and comfort. Pain, numbness, and reduced sensation make it a primary focus for stem cell therapy for diabetic neuropathy. Addressing nerve injury can help you regain movement and reduce discomfort. Targeted regenerative therapies focus on supporting damaged nerves and surrounding tissues, giving your body the resources it may need to function more effectively.
Biological Actions Being Investigated
Nerve Protection
Stem cells may support the integrity of damaged nerves. These cells interact with local tissues to encourage repair, which may help prevent further degeneration and maintain nerve signaling. Supporting nerve health can lead to improvements in sensation and reduce the impact of neuropathy on daily life.
Vascular Support
Stem cells may improve circulation in small blood vessels. Healthy blood flow helps maintain tissue function and supplies nutrients needed for nerve repair. Improved circulation may also help reduce discomfort and swelling associated with nerve damage.
Reduced Inflammatory Activity
Stem cells release factors that modulate immune activity. Reducing inflammation may slow further nerve injury and support a more favorable environment for tissue repair. Less inflammation can help improve overall nerve function and comfort.
Patient-Reported Outcomes Seen in Clinical Settings
Patients report improvements in energy, nerve discomfort, and daily activity. Some common experiences include:
Reduced tingling or burning sensations in hands and feet
Improved walking, balance, and coordination
Enhanced ability to perform daily activities
Emerging Applications for Other Diabetes-Related Complications
Diabetes affects more than just blood sugar levels. You may notice its impact on circulation, kidney function, and joint or muscle health, which can make daily activities more difficult. Stem cell therapies are being studied for their potential to support these areas.
Wound Healing and Circulation Support
Stem cell treatment for diabetes may support chronic wound repair. Slow-healing wounds are common in people with diabetes. Stem cells release molecules that can encourage tissue repair and improve blood flow. This may reduce the risk of infections and help maintain skin integrity.
Supports repair of small skin injuries and ulcers
Improves circulation in areas affected by poor blood flow
Promotes tissue regeneration through cellular signaling
Kidney Stress and Tissue Injury
Stem cells may help support kidney tissue affected by diabetes. Diabetes can place stress on kidney structures, leading to inflammation and gradual tissue damage. Stem cells can release factors that may help reduce inflammation and encourage repair of affected areas.
Supports kidney tissue integrity
Modulates inflammatory activity in kidney cells
May help reduce progression of tissue damage
Joint and Muscle Pain Linked to Diabetic Changes
Stem cells may support joint and muscle health. Many patients notice stiffness, soreness, or reduced mobility due to changes in muscle and connective tissues. Stem cell therapy may aid in controlling inflammation and supporting tissue recovery, which can help improve comfort and movement.
Reduces inflammatory activity in muscles and joints
Supports repair of connective tissues
Can improve day-to-day mobility and comfort
Why Many Patients Seek Help From Stemedix
Patients exploring regenerative medicine want a clear, patient-focused approach. This section highlights the support and guidance you receive throughout the process.
Regenerative Medicine Expertise
Stemedix focuses exclusively on regenerative medicine therapies. Our team applies research-backed methods to design treatments tailored to your specific condition. Every plan looks at your medical history, current test results, and personal needs to provide care that is precise and organized. You can expect a treatment path that is structured and guided by specialists familiar with the latest developments in stem cell applications for diabetes and related complications.
Board-Certified Providers
All therapies are approved by specialized, board-certified physicians. Each provider reviews your existing medical records and lab results to determine the most suitable therapy options. Our focus is on supporting your health through carefully considered regenerative approaches rather than offering new diagnoses.
Step-by-Step Coordination and Travel Assistance
Patients receive dedicated guidance throughout their journey. Care coordinators schedule appointments, help manage ground transportation, and assist with mobility aids such as wheelchairs or walkers if needed. This support allows you to focus on the treatment itself rather than logistical challenges.
Conditions Already Diagnosed by Each Patient’s Own Doctor
Stemedix treats pre-diagnosed conditions. The therapies offered are based solely on information provided by your own physician. Your treatment plan is built around existing medical records, ensuring that the therapy complements the care you are already receiving.
Take the Next Step with Stemedix
If you are exploring stem cell treatment for diabetes or related complications, Stemedix can guide you through the process. Our team works with you to review medical records, discuss potential therapy plans, and provide support every step of the way. To learn more or request information, contact us at (727) 456-8968 or email yourjourney@stemedix.com. Our staff is ready to answer your questions and help you begin the process of personalized regenerative care.
Medical Review: Dr. Gerald Mastaw, MD – Board-Certified Physician Last Updated: October 2025
What Is Degenerative Disc Disease?
Degenerative Disc Disease (DDD) occurs when the spinal discs, the soft, cushion-like pads between vertebrae, begin to lose hydration, elasticity, and height. As discs deteriorate, they absorb less shock, which can lead to pain, stiffness, and nerve irritation if nearby nerves are compressed.
Common Symptoms
Persistent or recurring neck or lower back pain
Discomfort that worsens with bending, lifting, or prolonged sitting
Stiffness after activity or upon waking
Tingling, numbness, or weakness in arms or legs if nerves are affected
Age is the most common cause, but injury, repetitive strain, genetics, smoking, and excess body weight can accelerate disc wear.
Conventional Treatment Approaches
Most patients start with conservative therapy focused on relieving pain and improving mobility.
Common Treatments
Physical therapy: improves flexibility, posture, and spinal support
Anti-inflammatory medications or short-term muscle relaxants
Heat, ice, or gentle stretching to ease discomfort
Epidural steroid injections for nerve-related pain
For more advanced cases, procedures like radiofrequency ablation, spinal decompression, or surgery (e.g., disc replacement or spinal fusion) may be considered.
While these treatments reduce symptoms, they do not restore disc structure or reverse degeneration.
Regenerative Medicine for Disc Health
Regenerative medicine aims to engage the body’s natural healing processes rather than simply masking pain.
Among the most studied approaches are umbilical cord tissue-derived mesenchymal stem cells (UCT-MSCs) and platelet-rich plasma (PRP) therapy.
How Regenerative Therapies Work
Stem cells release growth factors that can calm inflammation and support tissue regeneration.
PRP concentrates the body’s own platelets and growth factors to stimulate repair directly at the injury site.
Together, these methods may help reduce chronic pain, enhance mobility, and support long-term spinal function when paired with physical therapy and lifestyle adjustments.
Important: Stem cell and PRP therapies for degenerative disc disease are still considered experimental and are not FDA-approved. Ongoing clinical studies are assessing their safety, durability, and regenerative potential.
Recent Clinical Studies on Regenerative Treatments for Degenerative Disc Disease
2025 – Systematic Review of PRP for Discogenic Pain
Title:Stem Cells Therapy as a Treatment for Discogenic Low Back Pain: A Systematic Review Journal:International Journal of Spine Surgery – Read Study Summary: A randomized controlled trial compared PRP releasate (growth factors from a patient’s blood) versus steroid injections for discogenic back pain. Both groups improved initially, but PRP provided longer-lasting relief — with pain, disability, and quality-of-life improvements sustained for over 60 weeks. No safety issues were reported, and the study concluded PRP is a safe and effective alternative for long-term pain control compared to steroids.
2023 – Umbilical Cord MSC Injections for DDD Pain
Title:Pain Relief After Allogeneic Stem Cell Disc Therapy Journal:Pain Physician – PubMed Summary: Thirty-three patients with DDD received umbilical cord tissue-derived MSC injections (approximately 5 million cells per disc). At 2 years, patients experienced a 6.5-point reduction in pain scores and 38-point improvement in disability scores, with over 90% rating their results as good or excellent. No adverse reactions were observed. The study found MSC therapy significantly reduced chronic back pain and improved function.
Title:Allogeneic Mesenchymal Precursor Cells for Chronic Low Back Pain from DDD: A 36-Month Randomized Controlled Study Journal:Stem Cell Research & Therapy – PubMed Summary: In this 100-patient trial, participants received a single intradiscal injection of mesenchymal precursor cells (6 or 18 million) or placebo. At 3 years, MSC-treated patients maintained significant pain reduction and functional improvement compared to placebo. MRI scans showed stable disc appearance with no serious immune or safety issues. Researchers concluded intradiscal MSC therapy is a safe, durable, minimally invasive option for moderate DDD.
Could Regenerative Therapy Be Right for You?
You may be a candidate for regenerative therapy if you:
Have chronic back or neck pain from degenerative discs that hasn’t improved with conservative care
Prefer non-surgical approaches focused on repair rather than symptom masking
Seek to preserve spinal function and reduce long-term pain
At Stemedix, we emphasize education, safety, and scientific transparency. Our team offers personalized consultations to review your medical history, imaging, and goals to determine whether regenerative therapy could be an appropriate next step.
Medical Disclaimer
This page is for educational purposes only and does not constitute medical advice. Stem cell and PRP therapies for degenerative disc disease are not FDA-approved, and individual outcomes may vary. Always consult your physician or spine specialist before pursuing any treatment.
References
Sato T. et al. Stem Cells Therapy as a Treatment for Discogenic Low Back Pain: A Systematic Review.Int. J. Spine Surg., 2025. Full Text
Kim D. et al. Pain Relief After Allogeneic Stem Cell Disc Therapy.Pain Physician, 2023. PubMed
Mesoblast Trial Group. Allogeneic Mesenchymal Precursor Cells for Chronic Low Back Pain from DDD.Stem Cell Res Ther., 2020. PubMed
This website and its contents are not intended to treat, cure, diagnose, or prevent any disease. Stemedix, Inc. shall not be held liable for the medical claims made by patient testimonials or videos. They are not to be viewed as a guarantee for each individual. The efficacy for some products presented have not been confirmed by the Food and Drug Administration (FDA).
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