by admin | Apr 21, 2023 | Stem Cell Therapy, Spinal Cord Injury, Stem Cell Research
The National Institute of Health estimates that nearly 250,000 people in the United States are currently living with a spinal cord injury (SCI). Most often a result of an accident, SCIs typically result in the loss of neurons and axonal damage resulting in the loss of function.
SCIs can be divided into two distinct phases, the initial physical injury and the secondary injury which typically occurs hours to days later. In most cases of SCI, damage to the axonal and tissue damage is caused by compression and/or contusion to the spinal cord. The secondary SCI injury occurs in the hours and days after the initial injury and is characterized by persistent inflammation, glial scar formation, demyelination of surrounding neurons, and death of cells. Over time, research has demonstrated that, in all aspects of secondary injury, the inflammatory response is the major cause and leads to widespread cell damage and lesion expansion.
Recent research has demonstrated that stem cells, including mesenchymal stem cells, neural stem/progenitor, and embryonic stem cells, possess anti-inflammatory properties and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation.
In this review, Cheng and He discuss the general features of macrophages in response to SCI, the phenotype, and function of macrophages in SCI, and the effects of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI.
Macrophages accumulate in and around an SCI and play a very important role in neuroinflammation. Considering that recent research demonstrates the different, but important, contributions M1 and M2 macrophages make toward repairing tissue damage, this process is thought to be a promising therapeutic treatment for controlling the inflammation occurring after initial SCI.
According to this review, there are both positive and negative effects of macrophages on tissue repair and regeneration after an SCI. Interestingly, some studies show that infiltrating macrophages has harmful effects, especially in the early stages of an SCI. On the other hand, studies also indicated that macrophages have beneficial effects on tissue repair. These results included findings indicating that activated macrophages could provide a beneficial microenvironment that is good for the regeneration of sensory axons.
While the exact reason for the opposite effects of macrophages on the pathological process of SCI is not yet known, it’s thought to be because of the different phenotypes of macrophages – M1 (classical activation) and M2 (alternative activation).
Additionally, studies have demonstrated that M2 macrophages are important for efficient remyelination after CNS injury, while M1 macrophages hinder neurogenesis and inhibit neurite outgrowth and induce growth cone collapse of cortical neurons.
Considering these findings, the authors point out that polarization of macrophages to M2 is beneficial – and often preferred to M1- to facilitate the recovery after SCI. These findings have also demonstrated stem cell therapy to hold tremendous potential for therapeutic uses in the treatment/recovery after a spinal cord injury.
There is accumulating evidence indicating that the current preference of M2 macrophages compared to M1 macrophages correlates with remission of SCI in cases receiving SCI interventions including anti-inflammatory therapies and stem cells. The authors of this review conclude that while the exact process by which stem cells regulate macrophage polarization has yet to be determined, stem cells can alter macrophage polarization and promote functional recovery postinjury.
Source: “Anti-inflammatory effect of stem cells against spinal cord injury via | JN.” 13 Feb. 2017, https://www.dovepress.com/anti-inflammatory-effect-of-stem-cells-against-spinal-cord-injury-via–peer-reviewed-fulltext-article-JN.
by admin | Apr 19, 2023 | Health Awareness
Exercise is important for good health because it offers a wide range of benefits for both physical and mental well-being. Here are some of the key reasons why exercise is crucial for good health:
Strengthens the Muscles and Bones
Exercise helps to build and maintain strong muscles and bones, which is important for overall physical health, especially as we age. When we exercise, our muscles are put under stress, which causes them to break down and rebuild stronger than before. This process is known as muscle hypertrophy, and it is how our muscles become stronger and more resilient over time.
Reduces the Risk of Chronic Diseases
Chronic diseases are long-term health conditions that often develop over time and are often caused by a combination of genetic, environmental, and lifestyle factors. Regular exercise can help to reduce the risk of many chronic diseases that may impact your heart health, immune system, mental health, weight, and cognitive function.
Improves Heart Health
Yes, exercise is great for heart health. Regular physical activity helps to strengthen the heart and cardiovascular system, reducing the risk of heart disease, stroke, and other cardiovascular problems. Exercise helps to make the heart pump stronger, lowers blood pressure, reduces inflammation, improves cholesterol levels, and improves circulation. Overall, regular exercise is a critical component of heart health, and it can help to reduce the risk of heart disease and other cardiovascular problems.
Boosts the Immune System
The immune system is the body’s defense against infections and diseases, and it plays a crucial role in keeping us healthy. Exercise can boost the immune system by helping to improve circulation, reduce inflammation, increase antibody production, increase white blood cell counts, and reduce stress.
Improves Mental Health
Exercise has been shown to improve mood, reduce stress and anxiety, and boost overall well-being. Some ways that exercise can improve mental health is by releasing endorphins which are natural chemicals in the body that can improve mood and reduce pain. It can reduce levels of the stress hormone cortisol, which can have a positive impact on mental health. It also helps improve sleep which is crucial for maintaining good mental health.
Further, it can boost self-esteem which can have a positive impact on overall well-being. And finally, it can reduce symptoms of depression and anxiety. It is important to note that exercise is not a substitute for professional mental health treatment, but it can be an effective complement to therapy or medication.
Helps with Weight Management
Regular physical activity can help to burn calories, increase metabolism, and maintain a healthy weight. With exercise, you can burn calories, increase metabolism, preserve muscle mass, reduce appetite, and improve insulin sensitivity.
Enhances Brain Function
Regular physical activity has been shown to have numerous benefits for brain health, including improved cognitive function, memory, and mood. It can increase blood flow to the brain, delivering more oxygen and nutrients that are necessary for optimal brain function. It helps to boost neuroplasticity, which is the brain’s ability to adapt and change in response to new experiences and information.
Cognitive functions can be improved, including attention, memory, and processing speed. And exercise has been shown to increase the production of BDNF, which is a protein that promotes the growth and survival of neurons in the brain.
Overall, exercise is a critical component of a healthy lifestyle, and the benefits of physical activity extend far beyond just physical health, but it is important to find a balance and engage in moderate exercise that is appropriate for your fitness level and health status. Talk to your healthcare provider to determine the exercise plan best for you.
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by Stemedix | Apr 17, 2023 | Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). It occurs when the immune system mistakenly attacks and damages the protective covering of nerve fibers, called myelin, in the brain and spinal cord. A very commonly asked question is ” How does Multiple Sclerosis affect the body? “. Keep reading to learn more!
The myelin sheath is a protective covering that surrounds nerve fibers in the central nervous system (CNS). It is made up of a fatty substance called myelin, which is produced by specialized cells called oligodendrocytes in the CNS. The myelin sheath acts as an insulator and helps to speed up the transmission of electrical impulses along the nerve fibers.
The myelin sheath is important for the proper functioning of the nervous system. When it is damaged, nerve impulses can slow down or disrupt communication between the brain and other parts of the body, leading to a wide range of neurological symptoms.
In MS, when the myelin sheath is damaged, it can cause a wide range of symptoms. The severity and frequency of symptoms can vary widely between individuals with MS. Some of the most common symptoms of MS include:
- Muscle weakness and stiffness: MS can cause weakness and stiffness in the muscles, which can affect mobility and balance.
- Numbness and tingling: MS can cause numbness and tingling in the limbs, face, and other parts of the body.
- Vision problems: MS can affect the optic nerve, which can cause blurred or double vision, loss of vision, or pain behind the eyes.
- Fatigue: MS can cause extreme tiredness and lack of energy, even after minimal physical or mental activity.
- Cognitive problems: MS can affect cognitive functions such as memory, concentration, and problem-solving.
- Bladder and bowel problems: MS can cause problems with bladder and bowel function, such as incontinence or constipation.
- Emotional changes: MS can cause mood swings, depression, and anxiety.
The symptoms of MS can be unpredictable and can vary in severity over time. Treatment can help manage symptoms and slow the progression of the disease, but there is currently no cure for MS.
What Treatments or Therapies Help Multiple Sclerosis?
The exact cause of MS is not known, but it is thought to be a combination of genetic and environmental factors. There is currently no cure for MS, but treatments are available that can help manage symptoms, slow the progression of the disease, and improve quality of life.
The choice of treatment depends on the type and severity of MS, as well as the individual’s symptoms and overall health. Some options include:
Disease-modifying therapies (DMTs): These are medications that are used to slow down the progression of MS, reduce the frequency and severity of relapses, and help preserve cognitive function. There are several different types of DMTs available, including injectable medications, oral medications, and infusion therapies. As a medication, DMTs may cause side effects, which can vary depending on the medication. Common side effects include flu-like symptoms, injection site reactions, and gastrointestinal problems.
Overall, the decision to use DMTs should be made in consultation with a healthcare provider, taking into account the individual’s specific needs, goals, and potential risks and benefits.
Symptom management: MS can cause a wide range of symptoms, and there are several medications and therapies that can help manage these symptoms. For example, medications can be used to reduce muscle spasms, pain, and bladder and bowel problems. Physical therapy, occupational therapy, and speech therapy can also be helpful in managing symptoms.
Lifestyle changes: Certain lifestyle changes, such as regular exercise, a healthy diet, and stress management techniques, can help improve overall health and reduce the risk of MS relapses.
Exercise: Exercise can be an important part of managing multiple sclerosis (MS), as it can help improve strength, balance, flexibility, and overall quality of life. However, the best exercise for MS can vary depending on the individual’s symptoms and overall health. Some examples are aerobic exercise, strength training, yoga or tai chi, and water based exercise.
Diet: There is no one-size-fits-all diet for multiple sclerosis (MS), and the best diet for MS may vary depending on the individual’s symptoms and overall health. However, research suggests that a healthy, balanced diet can help improve overall health and well-being for people with MS. Here are some general principles of a healthy diet that may be beneficial for people with MS:
- Focus on whole foods: A diet rich in whole, nutrient-dense foods can help provide the vitamins, minerals, and antioxidants needed for optimal health. This includes fresh fruits and vegetables, whole grains, lean proteins, and healthy fats.
- Avoid processed foods: Processed foods, such as packaged snacks and sugary drinks, are often high in sugar, salt, and unhealthy fats. These foods can contribute to inflammation and may worsen MS symptoms.
- Consider an anti-inflammatory diet: Inflammation is thought to play a role in the development and progression of MS. Eating an anti-inflammatory diet, which includes foods such as fatty fish, nuts, seeds, and olive oil, may help reduce inflammation in the body.
- Supplement as needed: Some people with MS may have specific nutrient deficiencies, such as vitamin D or vitamin B12. In these cases, supplementation may be necessary to meet the body’s needs.
- Stay hydrated: Drinking plenty of water can help keep the body hydrated and may help reduce MS-related symptoms such as fatigue and constipation.
Stress Management: Stress is a common trigger for MS symptoms, so it is important for people with MS to learn stress management techniques to help them manage their condition. Here are some stress management techniques that may be helpful for people with MS. Some include meditation, breathing exercises, yoga, cognitive-behavioral therapy (CBT), and regular exercise.
Rehabilitation: Rehabilitation programs can help individuals with MS maintain or improve their physical and cognitive abilities. They can also help to manage symptoms, promote independence, and improve mental health. These programs may include physical therapy, occupational therapy, and speech therapy.
Alternative therapies: Some people with MS find that alternative therapies can be helpful in managing their symptoms and improving their quality of life. Here are some alternative therapies that some people with MS may find helpful:
- Acupuncture: Acupuncture involves the insertion of thin needles into specific points on the body. Some studies suggest that acupuncture may help relieve pain, fatigue, and other MS-related symptoms.
- Massage therapy: Massage therapy involves the manipulation of soft tissues to promote relaxation and relieve muscle tension. Some people with MS may find massage therapy helpful in reducing muscle spasms and improving overall relaxation.
- Mind-body therapies: Mind-body therapies, such as yoga, tai chi, and meditation, can help improve flexibility, balance, and relaxation. These practices may also help reduce stress and improve mood.
- Herbal remedies: Some herbal remedies, such as turmeric, ginkgo biloba, and omega-3 fatty acids, may have anti-inflammatory properties that could potentially help reduce inflammation in the body.
- It is important for individuals with MS to talk to their healthcare provider before starting any new alternative therapy, as some therapies may not be appropriate for certain symptoms or health conditions.
Regenerative Medicine for Multiple Sclerosis
Regenerative medicine, also known as stem cell therapy, is a rapidly evolving area of research and has shown promise in the treatment of multiple sclerosis (MS). Stem cells are unspecialized cells that have the potential to develop into many different types of cells to help repair damaged tissues or cells and reduce inflammation.
Mesenchymal stem cell (MSC) therapy is a type of regenerative medicine that uses stem cells derived from various tissues, including bone marrow, adipose tissue, and umbilical cord tissue, to treat a variety of conditions, including multiple sclerosis (MS).
Several clinical trials have investigated the use of MSC therapy in MS, and some have shown promising results. MSCs have anti-inflammatory and immunomodulatory properties, which may be beneficial in the treatment of MS. MSCs can also promote the regeneration of damaged tissue, which may help improve symptoms.
One small clinical trial published in 2018 showed that treatment with MSCs improved clinical outcomes and reduced inflammation in individuals with MS. Another study published in 2019 showed that MSCs derived from umbilical cord tissue reduced inflammation and improved motor function. As with any medical treatment, the decision to undergo MSC therapy for MS should be an informed decision and with a provider that has experience and has a positive reputation. Would you like to speak with a professional to help answer the question ” How does Multiple Sclerosis affect the body? “. Contact a care coordinator today at Stemedix to learn more!