Erectile Dysfunction

Regenerative medicine for erectile dysfunction, platelet-rich plasma (PRP) therapy, and low-intensity extracorporeal shockwave therapy are being studied as distinct approaches for selected people with ED. Researchers are evaluating different products, delivery methods, treatment schedules, and outcomes related to erectile function, vascular measures, and quality of life.

What Researchers Are Studying

• Be delivered safely and feasibly in carefully selected patients
• Influence local tissue signaling, blood-flow measures, or other biological processes
• Be further evaluated for effects on erectile-function scores and other patient-reported outcomes
• Help identify which approaches and patient groups warrant continued clinical research

PRP, cell-based products, and shockwave therapy are distinct approaches. Their evidence, intended use, risks, and treatment protocols differ.

Note: Stem cell and PRP therapies for erectile dysfunction are investigational and are not FDA-approved for this use. Research findings do not guarantee individual results.

How Regenerative Medicine for Erectile Dysfunction Is Being Studied

Researchers are studying cell-based approaches, PRP, and low-intensity shockwave therapy in selected people with ED. Studies assess safety, erectile-function scores, erection-hardness measures, blood-flow measures, sexual satisfaction, and quality of life. This work is helping identify the approaches and patient groups that warrant continued clinical study. Stem cell treatment for erectile dysfunction remains investigational.

2025: Low-Intensity Shockwave Therapy Meta-Analysis Reported Improved Erectile-Function Scores

Efficacy of Extracorporeal Shock Waves Therapy for Erectile Dysfunction Treatment: A Systematic Review and Meta-Analysis — Read Study

This systematic review and meta-analysis evaluated 15 studies of extracorporeal shockwave therapy for erectile dysfunction, including organic ED and ED after nerve-sparing radical prostatectomy. The pooled analysis found improved erectile-function scores in the shockwave-treatment group compared with controls, with a mean difference of 2.96 points. The review also described findings related to erectile efficacy and sexual satisfaction, providing encouraging clinical support for continued investigation of low-intensity shockwave therapy as a noninvasive approach for erectile dysfunction.

2021: Wharton’s Jelly-Derived MSC Injections Reported Erectile-Function and Blood-Flow Improvements in Diabetic ED

Safety and Efficacy of 2 Intracavernous Injections of Allogeneic Wharton’s Jelly-Derived Mesenchymal Stem Cells in Diabetic Patients With Erectile Dysfunction: Phase I/II Clinical Trial — Read Study

This phase I/II clinical trial included 22 men with diabetes and refractory erectile dysfunction who received two intracavernosal injections of allogeneic Wharton’s Jelly-derived MSCs. The procedure was well tolerated, with minimal transient redness or bruising and no patient-reported serious adverse effects. The investigators reported improvements from baseline in IIEF-5, erection-hardness, and Doppler blood-flow measures during follow-up, providing encouraging support for continued study of this MSC approach in diabetic erectile dysfunction.

2021: PRP Injections Reported Improved Erectile-Function Scores in a Randomized Trial

Platelet-Rich Plasma Improves Erectile Function: A Double-Blind Randomized Placebo-Controlled Trial — Read Study

This double-blind, randomized, placebo-controlled trial evaluated two PRP injections, given one month apart, in 60 men with mild-to-moderate erectile dysfunction. At six months, the study reported that 69% of participants in the PRP group achieved a meaningful improvement in erectile-function scores, compared with 27% of participants in the placebo group, with no adverse events reported. These randomized findings provide encouraging early clinical support for continued research on PRP for erectile dysfunction.

For people with persistent erectile dysfunction, regenerative medicine for erectile dysfunction and other investigational approaches may be topics to discuss with a healthcare provider. A consultation can help review symptoms, medical history, medications, cardiovascular and metabolic risk factors, relevant laboratory results, and treatment goals. You may also wish to learn more about hormone optimization therapy and PRP therapy, since the evidence for a particular approach may differ by diagnosis, treatment method, and outcome measured.

At Stemedix, we take a patient-centered approach to regenerative medicine, informed by emerging clinical research. Our team reviews your health history, current treatment plan, and goals to help determine whether an investigational regenerative approach may be appropriate to explore.

This information is for educational purposes only and does not constitute medical advice.
Stem cell, PRP, and shockwave therapies for erectile dysfunction are investigational and are not FDA-approved for this use. Research findings do not guarantee individual results.
Always consult a qualified healthcare professional before making treatment decisions.

1. Ergun O. et al. Low-Intensity Shockwave Therapy for Erectile Dysfunction. Cochrane Database of Systematic Reviews., 2025. PubMed
2. Al Demour S. et al. Stem Cell Therapy in Diabetic Men With Erectile Dysfunction: A 24-Month Follow-Up of Safety and Efficacy. Basic and Clinical Andrology., 2024. PubMed
3. de Amorim LGCR. et al. Efficacy of Platelet-Rich Therapies Versus Placebo in the Treatment of Erectile Dysfunction. Journal of Sexual Medicine., 2026. PubMed

U.S. Food and Drug Administration. Important Patient and Consumer Information About Regenerative Medicine Therapies. FDA