Human umbilical cord Wharton’s Jelly derived mesenchymal stem cells (WJ-MSCs) are reported as the most potent cell source of MSCs, however, they remain understudied in comparison to other autologous sources of MSCs. Mehling et al.’s study aimed to evaluate the safety of WJ-MSC therapy for a range of conditions and administration routines, including intravenous, intrathecal,…
What is Multiple Sclerosis? Multiple Sclerosis (MS) is a chronic and potentially disabling autoimmune disease that affects the central nervous system (CNS). The central nervous system comprises the brain and the spinal cord, which are responsible for transmitting signals between the body and the brain to control various bodily functions. In MS, the immune system…
Because of its ability to simultaneously activate multiple mechanisms, including paracrine, trophic, immunomodulatory, and differentiation, researchers consider mesenchymal stem cells to be an effective option for stem cell therapy. After years of active research, bone marrow-derived MSCs (BM-MSCs) have been a prevalent source for MSC-based studies. There is also active research using MSCs from a…
What is Post Stroke and How is it Diagnosed? "Post-stroke" or "post-stroke period" refers to the period of time following a stroke. A stroke occurs when there is a sudden disruption of blood flow to a part of the brain, leading to brain cell damage and, potentially, the death of brain tissue. The severity and…
According to the CDC, an estimated 3.1 million adults (1.3%) in the United States have been diagnosed with inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis. Characterized by abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition, CD is thought to be the result of swelling and inflammation of the tissue…
Researchers continue to tout the potential of mesenchymal stem cells (MSCs) as an evolving approach for the repair of damaged tissue or lost cells. Specifically, the ability of MSCs to differentiate and secrete beneficial factors and vesicles is believed to play the most influential role in the regeneration of injured tissues and cells affected by…
What is Kidney Disease? Kidney disease, also known as renal disease or nephropathy, refers to a condition in which the kidneys are damaged or unable to function properly. The kidneys play a crucial role in filtering waste products, excess fluid, and toxins from the blood, while also maintaining the body's electrolyte balance and producing important…
Osteoarthritis (OA) is the most common and widespread form of arthritis, affecting an estimated 655 million people worldwide. Occurring as a result of cartilage degeneration, OA is a progressive degenerative disorder that most commonly affects the joints of the hands, hips, knees, and spine. Although OA can affect anyone, it is most commonly observed in…
Transverse myelitis is a neurological condition characterized by inflammation of the spinal cord. It occurs when the immune system mistakenly attacks the spinal cord, damaging the nerve fibers and causing various neurological symptoms. The inflammation in transverse myelitis disrupts the normal functioning of the spinal cord, affecting the transmission of nerve signals between the brain…
Mesenchymal stem cells (MSCs) isolated from a wide variety of tissues and organs have demonstrated immunomodulatory, anti-inflammatory, and regenerative properties that contribute to a host of regenerative and immunomodulatory activities, including tissue homeostasis and tissue repair. The most frequently studied and reported sources of MSCs are those collected from bone marrow and adipose tissue. In this…
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