by admin | Aug 21, 2018 | Stem Cell Therapy, Wharton's Jelly
Mesenchymal stem cells have been showing promise in the treatment of a variety of diseases and injuries. These cells are derived from different tissue types, and it appears that where the stem cells come from is indicative of how they function and how appropriate they are for use in different applications. Bone marrow-derived mesenchymal stem cells have been deeply studied and are often considered a go-to for stem cell research and clinical use.
However, there are several limitations that bone marrow-derived mesenchymal stem cells pose, particularly from a practicality standpoint, and thus, researchers have begun to try to understand how other types of stem cells may achieve similar or better results than those from the bone marrow. A recent review, published in Act Histochemical, compiled comprehensive data on the biological properties associated with a specific type of mesenchymal stem cell called Wharton’s Jelly-derived mesenchymal stem cells.
These stem cells, which come from the umbilical cord, are able to differentiate into mature cells that make up several different types of tissues and can even turn into non-mesenchymal cells, such as neurons, or brain cells. They are useful in that they spontaneously move to sites of injury or inflammation and may, therefore, be able to help restore tissue and normal functioning. They are also unlikely to instigate adverse immune system reactions.
While it is advantageous that bone marrow-derived mesenchymal stem cells have been studied extensively and therefore are associated with broad knowledge of therapeutic applicability, the cells are difficult to isolate and use. In contract, cells from the umbilical cord matrix, or Wharton’s jelly, are easy to isolate and also appear to be good candidates for therapeutic intervention. Future research should therefore look more closely at how Wharton’s jelly-derived mesenchymal stem cells can be used to treat disease and injury. As noted by the authors of this review, there are specifically dysfunctions of the central and peripheral nervous system that these stem cells may be able to address.
by admin | Aug 20, 2018 | Health Awareness
What is Magnesium?
Magnesium is a mineral required by the body to work efficiently. It aids the body in carrying out almost hundreds of different processes like controlling how our nerves and muscles function. Magnesium keeps the bones strong, maintains good heart health and also keeps the sugar levels in the blood under control. It also maintains the vitality of the body. It is present in various drinks and foods but if your body requires more of it then your doctor can also suggest you take supplements. In this article, we review the benefits and sources of magnesium.
How Much is Required?
Grown men under the age of 31 require 400 to 420 milligrams of magnesium daily. An adult woman requires around 310 milligrams of magnesium and if she is pregnant then another 40 grams is needed. Children can require anywhere from 30 to 410 mg depending on their gender and age. It is best to talk to their pediatrician to find out how much your child may require according to their need.
Are You Getting the Required Dose?
It is observed that two-thirds of the western world does not have the proper required intake of magnesium, this leads to a variety of health related issues like high blood pressure, diabetes and migraines. People who are older in ages tend to have a higher deficiency of magnesium than others because their bodies expel a large amount of magnesium than normal.
Can You Take Too Much Magnesium?
Healthy individuals can flush out any extra magnesium from the body through their kidneys but still, a very high intake of magnesium can lead to nausea and cramps. Taking magnesium as a supplement, it is best suggested to not take more than 350 mg per day. Be cautious when using antacids and laxatives that contain magnesium to avoid too much intake that may lead to sickness.
Benefits of Magnesium
Stronger Bones
Magnesium is required by the body to produce new bone cells, research also shows that magnesium protects the body against broken bones, bone loss, and osteoporosis. Studies have also revealed that women who have osteoporosis have a very low level of magnesium than normal.
Fights Inflammation
Inflammation is the reaction of the body’s immune system to heal the wounds and fight off viruses. But if the body is always under inflammation then this can lead to issues like diabetes, arthritis and heart diseases. Magnesium helps in the prevention of inflammation.
Protects the Heart
Magnesium aids in pumping the blood. The right amount of magnesium in the blood decreases the chance of a heart disease, stroke, and irregular heartbeat. Magnesium can also help maintain good cholesterol levels in the blood as well as relax the walls of the blood vessels to keep blood pressure under control.
Prevents Migraines
Magnesium can prevent blood vessels from tightening and lowers the pain chemicals in the brain. Low magnesium levels could make you more prone to getting migraines. A recommended dose of 400 to 500 mg of magnesium may help to keep migraines away. But consult with your physician to determine the right level for you.
Lowers Risks of Diabetes
Insulin is the hormone responsible for keeping the blood sugar levels under control. Magnesium aids insulin in working efficiently. Studies reveal that people who took the right amount of magnesium were least likely to develop diabetes or could improve symptoms of those with diabetes.
Food Sources of Magnesium
Nuts and Seeds
An ounce of cashews and almonds can give you almost 80 milligrams of magnesium. Other sources can include pecans, peanuts, flax seeds, pumpkins seeds and sunflower seeds. You can garnish a salad with these nuts and seeds, you will get a healthy amount of fats, antioxidants, and fiber that is heart healthy.
Whole Grains
Regarding nutrition, whole grains outweigh benefits than white bread. They are rich in fiber and magnesium. Just two slices of wheat bread can give you 45 milligrams of magnesium, half cup of oatmeal can give you 30 milligrams and half cup of brown rice contains around 40 milligrams of magnesium.
by admin | Aug 16, 2018 | Hyperbaric Oxygen Therapy, Bone Marrow, Stem Cell Research
Stem cells are generating so much excitement in research and clinical circles because they have the capacity to become many other types of cells. They also release a number of important molecules such as hormones, cytokines, and genetic material that can potentially be helpful for patients. Researchers have found that not only does hyperbaric oxygen therapy (HBOT) help in the circulation of stem cells but it also will help to mobilize stem cells from the bone marrow to the bloodstream further preparing the patient for stem cell therapy.
Bone marrow is a rich source of stem cells, but getting them usually requires an invasive procedure, i.e., placing a large bore needle into the middle of bone(s). Researchers have discovered, however, that hyperbaric oxygen treatment causes stem cells from the bone marrow to move into the bloodstream by specifically stimulating the body’s nitric oxide synthesis. Thus, instead of using a needle to extract stem cells from the bone marrow, patients can potentially increase their own bone marrow stem cells by undergoing hyperbaric oxygen treatment.
Stephen Thom, MD, Ph.D. and co-researchers at the University of Pennsylvania showed that a single hyperbaric oxygen treatment could double the number of bone marrow stem cells in the blood. This means that the hyperbaric oxygen was “mobilizing” the stem cells to move from the bone marrow into the bloodstream to allow them to move into areas of the body that benefit from them. Moreover, when study subjects underwent 20 treatments of hyperbaric oxygen therapy over a few weeks, the number of bone marrow stem cells in the blood increased significantly by eightfold. This astonishing finding has been confirmed in subsequent experiments.
The most important conclusion from this research is that hyperbaric oxygen therapy treatments can unlock the potential of a person’s own bone marrow stem cells without an invasive procedure. While many scientists assumed that the benefits of hyperbaric oxygen therapy were due to the high concentrations of oxygen infusing the blood, tissues, and cells, they now have research to support that these benefits may also be due to stem cell mobilization.
by admin | Aug 15, 2018 | Health Awareness, Heart Failure
Heart disease is one of the most prevalent heart condition that affects both genders, but there are certain heart conditions that affect only women and have different symptoms. For women, what are the signs to look for and what can they do to manage and be preventative.
Warning Signs
Many believe that during a heart attack one experiences severe chest pain, however, this may not be the case for all. Women usually have less obvious signs like shortness of breath, pain in the back, upper belly and jaw. Some may also feel light-headed, dizzy or nauseous.
Broken Heart Syndrome
The official term for this condition is stress-induced cardiomyopathy, and it’s more likely to happen to women as compared to men. It’s caused by an abrupt release of stress hormones, and it happens after very emotional events like divorce or a death in your family. A part of your heart gets bigger and can’t pump blood properly. This can cause intense chest pain, but with quick treatment, this can lead to a full recovery.
SCAD
This condition is called the spontaneous coronary artery dissection which occurs when one of the blood vessels of the heart tears. This can lead to a block or slowing down of the blood flow causing intense pain the chest along with many other symptoms. SCAD is a serious heart condition that requires immediate treatment. This happens more in women who have recently given birth.
Menopause
Menopause doesn’t cause heart disease, but the body changes a woman experiences may make her more likely to develop the condition. As the levels of estrogen in the body decrease, arteries become stiffer. After menopause, the belly fat, blood pressure and bad cholesterol levels increase so it is suggested to stay active to keep the heart healthy.
Inflammation
If you have a condition like lupus or arthritis that cause inflammation, then you have more risk to develop a heart disease. By managing inflammation and avoiding steroids, this can help prevent developing heart disease. It is suggested to consult with your doctor for the best way to protect your heart.
Diabetes
Your chances of developing heart disease is greater if you have diabetes. The sugar in the blood slows down the flow of oxygen and this can lead to a buildup of plaque in the arteries. Women who have diabetes are generally over weight with high cholesterol and blood pressure. Try to keep your sugar levels and weight under control with proper diet and exercise.
Depression
Suffering from depression can also increase your chances of having heart disease. It can cause you to stay inactive and neglect your health. The continuous stress and anxiety can have a bad impact on the heart. Talk to your doctor if you think you need help managing depression.
Being Thin Does Not Guarantee a Healthy Heart
Yes, women who are overweight are more likely to have a heart condition but being thin doesn’t eliminate you from the risks for high blood pressure and cholesterol.
Steps for Prevention:
Check Your Family Tree
If women in your immediate family, like your sister or mother, have had a heart condition before the age of 65 or if they’ve had a stroke, you may have a greater chance to have heart disease. It Is best to let your doctor know your family history so they can help you lower your chances.
Quit Smoking
Smoking can also increase the odds of the condition as well as your chances of a stroke by 25%. Smoking damages the blood vessels and increases blood pressure, which can lead to blood clots.
Watch Your Cholesterol
Cholesterol can build up in the arteries causing plaque to build up and harden and clog the arteries. By taking a routine blood test, you can be aware of your cholesterol levels. If your bad cholesterol levels are high, try making small changes like reducing sugar and fat intake while increasing more frequent exercise.
Manage a Healthy Weight
Eat fresh foods that are low in calories, fats and sodium. Take heart healthy cooking classes or watch online videos. Find activities that are fun and active, like going for a walk with a friend or taking a Zumba class.
Fitness Matters More After 40
Making small changes to your daily routine can significantly help. Even if you have never worked out, take the necessary steps to maintain your fitness after you hit your 40s. You can cut your chances of heart conditions by engaging in regular exercise.
Pregnancy Heart Protection
During pregnancy, the heart pumps more blood than usual. This can lead to excessive stress on the arteries and heart. Women who already experience valve issues should look out for signs like a fast heart rate, shortness of breath and infections during pregnancy. If you have high blood pressure be careful as it can lead to a condition called preeclampsia that can be of threat to both the mother and the baby.
by admin | Aug 14, 2018 | Bone Marrow, Stem Cell Research
Colitis is inflammation of the colon, also known as the large intestine. Several things can cause colitis such as infection, medication, ischemia, or chronic inflammatory bowel disease. Inflammatory bowel diseases that affect the colon, such as ulcerative colitis or Crohn’s disease, are particularly challenging for patients. It is a chronic disease that causes cramping pain, bloody diarrhea, weight loss, fatigue, and many other chronic, challenging symptoms.
Since ulcerative colitis does not occur naturally in animals, researchers sometimes use an experimental form of colitis to mimic the disease seen in humans. This experimental colitis serves as a model to investigate treatments for inflammatory bowel disease. Essentially, researchers create a situation in which mice develop a condition that looks very much like ulcerative colitis. They develop inflammation in the large intestine, along with signs of oxidative stress and cell death. Conversely, treatments for ulcerative colitis reduce or prevent inflammation, oxidative stress, and cell death in the colon of these experimental mice.
Researchers used this model of experimental colitis to study the effect of bone marrow stem cells as a treatment for colitis. More specifically, they tested the effects of a certain part of bone marrow stem cells called extracellular vesicles. Extracellular vesicles are small spheres that containing various beneficial substances. Stem cells release these vesicles into the body. A single stem cell can release hundreds of extracellular vesicles. In fact, it is the extracellular vesicles that are believed to contain many of the useful substances that are released by bone marrow stem cells such as proteins, lipids, and nucleic acids. These substances can precisely target sick and damaged cells in the body and repair them.
Impressively, when researchers used extracellular vesicles derived from bone marrow stem cells to treat animals with experimental colitis, they observed rather extraordinary results. These vesicles protected the intestines from colitis damage. Untreated animals had severely damaged intestines when viewed under a microscope, but animals treated with extracellular vesicles had nearly normal looking intestines. Treatment also substantially reduced levels of cytokines related to oxidative stress, such as IL-1β. Extracellular vesicles derived from bone marrow stem cells also apparently blocked the intestinal cells’ ability to undergo cell suicide (apoptosis).
Taken together, these results strongly suggest that mesenchymal stem cells from bone marrow, specifically the extracellular vesicles contained within them, can dramatically improve experimental colitis. While more research is needed, this study suggests that these stem cell products could one day be a useful treatment for inflammatory bowel diseases, such as ulcerative colitis and inflammatory bowel disease.
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