by admin | Aug 8, 2019 | Health Awareness
For quite some time now, scientists and medical experts have known that gut bacteria and the immune system appear to be closely intertwined. Until very recently, however, the precise mechanisms behind this connection have been unclear. In late May, researchers revealed groundbreaking findings observed in animal studies which suggest how the intestines may help regulate our overall health.
The Role of the Lower GI Tract
In mammals, the intestinal system allows healthy nutrients to pass through its walls, while at the same time blocking harmful bacteria from spreading throughout the body. In particular, the lower gastrointestinal (GI) tract is where most of these activities take place: food is processed until it becomes fundamental nutrients, which then pass through the intestinal wall to the bloodstream and to our vital organs. But the question of how the intestinal wall prevents the harmful bacteria from escaping with these nutrients has puzzled researchers.
Now, researchers from Rockefeller University in New York City think they may have an answer. Their study findings show that in mice, a sophisticated intestinal system has been observed. Specifically, certain areas of the GI tract are more likely to elicit an immune system response than others when encountering pathogens. While the intestines look similar, closer inspection reveals a complex intestinal immune system with a unique, organized structure.
Key Differences Throughout the GI System
Interestingly, researchers found that lymph nodes in mice’s large intestines would detect and combat harmful bacteria such as salmonella, whereas small intestines seemed to primarily carry out nutrient absorption and delivery to the bloodstream. According to the researchers, the ability to pinpoint the areas in the intestines which produce the most powerful immune system response could help medical experts create more targeted therapies for GI conditions. They also suspect that the findings could make oral vaccines, which have previously failed to produce an ample immune response, a possibility in the future.
While there is clearly still much to glean from microbiome research, we do know that maintaining healthy gut bacteria can have numerous benefits for our bodies. From eating a diet rich in plant-based food sources to taking supplements as recommended or approved by your doctor, there are many ways you can work towards maintaining a healthy balance of gut flora.
by admin | Jul 31, 2019 | Health Awareness
B vitamins have a powerful impact on the body, contributing to a broad range of processes that help us function every day. The eight B vitamins aid in converting food into fuel to support the metabolism. They’re also vital to blood cell development, brain and liver function, eyesight, and maintaining vibrant skin and nails. Yet, of the eight B vitamins, there’s one standout contender which has an especially important job: vitamin B6.
The Power of Vitamin B6
Also known as pyridoxine, vitamin B6 is essential for nervous system health and brain development. It is used in the production of hemoglobin, the critical protein which helps transport oxygen throughout the body via blood. It also supports a healthy immune system.
While B6 is critical for brain development in children, it’s also needed to support brain health at every age. The vitamin supports the production of key hormones, including serotonin. This neurotransmitter contributes to feelings of happiness and wellbeing, but its complex biological function extends far beyond mood regulation. In fact, serotonin also modulates cognition, memory, and various physiological processes.
Vitamin B6 also helps the body produce melatonin, the hormone that corresponds with daylight and helps us maintain healthy sleep patterns. Melatonin production declines naturally with age, and emerging research is exploring the connection between the hormone and reduced cognitive function in people with dementia.
To that end, researchers are also studying the impact of B vitamins on aging brains. Some studies suggest a combination of B6, B12, and folate could minimize age-related memory loss and cognitive decline, while also reducing the risk of Alzheimer’s.
How Much B6 Do You Need?
Recommended daily values for B6 change with age and you should always consult with your physician before adding any supplements to your daily regimen. While children need relatively little (just 0.5 mg for children aged 1 to 3, for example), men and women aged 19 to 50 should aim for 1.3 mg per day. For men aged 51 and over, 1.7 mg is recommended, while women of the same ages should stick to 1.5 mg. With that said, vitamin B6 is water soluble, meaning that any excess amount you take in that the body cannot use will exit as waste. Thus, unlike fat-soluble vitamins which are absorbed by the body when taken in excess, B6 and other water-soluble vitamins pose very little threat of toxicity.
What Are Some Good Sources of B6?
Some people with chronic diseases, including Crohn’s disease, celiac disease, and ulcerative colitis could be at risk of vitamin deficiencies and should speak with their healthcare providers about alternate means of ensuring ample nutrition. Most other people who eat a healthy, varied diet with plenty of whole foods are likely to take in adequate amounts of B6.
Yet, it’s not always easy to maintain optimal eating habits with every meal, which is why it may be a good idea to pay close attention to your B6 intake. Meat, poultry, and fish are rich in B6, so people following plant-based diets could be more likely to get lower amounts of B6. Chickpeas, nuts, beans, bananas, and potatoes also contain the vitamin, however.
If you’re concerned about your vitamin B6 intake, you might consider discussing supplements with your doctor. B6 is available in both multivitamins and as a standalone supplement. Taking a daily vitamin can help fill in any nutritional gaps in your diet, and as further research is conducted, it may also be confirmed that increasing the intake of this powerful vitamin could benefit populations with cognitive or health concerns.
by admin | Jul 29, 2019 | Exosomes, Mesenchymal Stem Cells
Periodontal disease, better known as gum disease, is very common. About half of all adults have chronic gum disease, and as many as 15% had severe periodontal disease. In periodontal disease, the gums become red and inflamed. The tissues that connect the tooth to the bone, such as the periodontal ligament, are damaged or destroyed. Chronic periodontal disease can even invade and destroy jaw bone. Making matters worse, as the gums recede, they can collect bacteria in spaces called periodontal pockets. Over time, these periodontal pockets can become dental abscesses. As the gums become more and more diseased, the affected tooth or teeth may fall out.
The treatment for periodontal disease varies depending on its severity. Good oral hygiene including regular brushing and flossing can reverse mild periodontitis. A dentist can deeply clean, probe and disrupt periodontal pockets. In more severe cases, topical antiseptics or oral antibiotics may be required. Less often, a dental surgeon must remove diseased areas of gum and bone.
Periodontitis usually chronic and causes significant ongoing inflammation. Thus, the gums take a long time to heal. In many cases, periodontal disease can be difficult to treat.
Fortunately, dental researchers have been exploring ways to use mesenchymal stem cells to help the healing process. More specifically, they have been using the exosomes released by mesenchymal stem cells. Exosomes are small packets of proteins, RNA, and other molecules that help promote growth and tissue regeneration. Since exosomes are not cells, they are much easier to collect, store, transport, and administer to patients. Most importantly, exosomes appear to contain all of the things that make stem cells so powerful in regenerative medicine.
In a 2019 study, Dr. Chew and colleagues used exosomes collected from mesenchymal stem cells to treat rats with periodontal disease. The researchers noticed that animals treated with exosomes healed much faster than untreated animals. Exosomes taken from mesenchymal stem cells promoted periodontal tissue regeneration helped grow new bone and regrew periodontal ligaments. The researchers also found that exosomes were able to recruit new cells to replace the damaged ones.
This scientific research is an exciting breakthrough in the fields of dentistry and periodontics. Chew and co-authors have shown that mesenchymal stem cell exosomes could enhance periodontal tissue regeneration without any adverse effects. The scientists go on to state that these findings will serve as the basis for future “cell-free” exosome treatments for periodontal disease. This is certainly good news for the more than 150 million Americans with periodontitis.
Reference: Chew, JRJ. et al. (2019). Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration. Acta Biomaterialia. 2019 Apr 15;89:252-264.
by admin | Jul 25, 2019 | Age Management, Mesenchymal Stem Cells, Stem Cell Research
Aging skin goes through a number of predictable changes. Skin loses collagen and other proteins as it ages, making the skin appear dull, saggy, discolored, and wrinkly. Many of these changes are due to the sun, as it bombards the skin with harmful ultraviolet (UV) radiation. When the skin is exposed to the sun’s UV radiation, it produces reactive oxygen species and leads to oxidative stress. The result is of these oxygen radicals is thickened, damaged, photo-aged skin. Unfortunately, the cells that could help replenish and rejuvenate the skin—epidermal progenitor cells—may also be damaged by UV radiation. Indeed, as we age, we produce fewer and fewer of these helpful cells. Thus, the skin is left defenseless.
Researchers are looking for ways to fight back against the ravaging effects of age and sun damage on human skin. Some have reasoned that if the skin lacks epidermal progenitor cells during aging, why not try to protect or restore those cells? Consequently, some scientists have studied the effects of injecting stem cells directly into the skin (with promising results). However, many patients would like to have the same skin rejuvenation effect without painful injections. Scientists are learning that the beneficial effects of stem cells come mostly from the things that they secrete rather than the stem cells themselves. This means that doctors could potentially take the fluid that a stem cell secretes and use that liquid as a treatment, rather than injecting whole stem cells into a patient’s skin. Indeed, this is the approach that researchers recently pursued and published.
Researchers began their research by collecting epidermal progenitor cells taken from mesenchymal stem cells. These epidermal progenitor cells are the stem cells that give rise to skin. Epidermal progenitor cells also produce substances that help support natural, youthful skin growth and development. The researchers allowed these epidermal progenitor cells to produce and release substances into the surrounding solution. They then collected that solution and used it in subsequent experiments.
In the first set of experiments, researchers showed that the cell-free fluid derived from stem cells could protect skin cells from oxidative stress caused by hydrogen peroxide. Indeed, something (or things) released by the stem cells prevented skin cells from undergoing the types of changes they would endure during sun damage. In fact, the treatment apparently caused the skin to increase its own natural defenses by producing more antioxidant enzymes and increasing the creation of new collagen.
Encouraged by these results, the researchers then conducted a clinical study of 25 people between the ages of 29 and 69. They took the same cell-free fluid derived from stem cells and applied it topically to the skin of volunteers twice a day for four weeks. The treatment significantly reduced skin depressions and wrinkles. Treatment also noticeably improved the texture of the skin.
Given the apparent safety and efficacy of this cell-free treatment, researchers are likely to continue to test these treatments in larger clinical trials. The results are exciting because they offer the possibility of a topical stem cell treatment without directly injecting stem cells themselves. Indeed, patients may someday be able to use cell-free stem cell skin rejuvenation treatments at home.
Reference: Sohn, SJ. et al. (2018). Anti-aging Properties of Conditioned Media of Epidermal Progenitor Cells Derived from Mesenchymal Stem Cells. Dermatology and Therapy. 2018 Jun;8(2):229-244.
by admin | Jul 23, 2019 | Health Awareness
Bone broth appears to be popping up everywhere these days. Hailed for its powerful nutritious properties among communities of health-conscious individuals, the stock can be made right at home and may provide a wealth of health benefits. Although research behind its benefits is still ongoing, millennia of broth drinkers can’t be wrong. Discover what the broth is made of and how it could benefit you below.
What is Bone Broth?
The history of bone broth extends all the way back to prehistoric times when hunter-gatherers would use animal parts they couldn’t otherwise consume into a drinkable broth. The diverse solution can be made from virtually any animal, and you don’t even need a recipe: just mix together water, vinegar, and bones in a large pot. If you do prefer to follow a formula for your first try, there are many recipes available online.
What Are the Benefits of Bone Broth?
The health drink is rich in the protein collagen, which, when cooked, becomes gelatin. The gelatin provides critical amino acids, but in addition, the animal bones themselves are loaded with key nutrients such as calcium, potassium, magnesium, and phosphorus. Marrow is also replete with vitamins A, and K2, along with zinc, iron, and omega-3 fatty acids. Many individuals – even those who eat well – have gaps in their diets, so adding bone broth can help address them.
Beyond bone broth’s rich vitamin and mineral concentration, it is also believed to have a number of key benefits. Some evidence shows that bone broth:
- Boosts digestive health. The solution is highly digestible and also promotes the digestion of other foods, as gelatin binds to water in the digestive tract to move food through. Moreover, it’s suspected that the gelatin can help intestinal wall permeability, known as leaky gut syndrome.
- Helps you achieve cosmetic goals. By improving connective tissues, it’s suspected that the broth could reduce the appearance of cellulite, improve hair and nail strength, and re-mineralize teeth.
- Improves joint health. Animal bones are products which, under normal circumstances, are inedible. Yet, they’re rich in collagen, which can be formed into gelatin that the body can use to strengthen its own connective tissues. Thus, drinking bone broth may improve joint health, especially in individuals with conditions like osteoarthritis.
- Reduces inflammation. Amino acids glycine and arginine found naturally in bone broth, are known for fighting inflammation. Chronic inflammation is suspected to play a key role in many serious conditions, including Alzheimer’s disease, heart disease, diabetes, and certain types of cancer, among other illnesses.
- Kickstarts weight loss. Although bone broth is typically low-calorie, it’s also very satiating. Thanks to the gelatin, you’ll likely feel full long after drinking the broth, even though you’ve only consumed a few calories. It’s also been shown to reduce fat and increase muscle strength.
- Improves sleep quality. Finally, the glycine present in bone broth may also aid in sleep regulation. Thus, anyone who has difficulty falling or staying asleep may wish to incorporate broth into their nightly routine, as it won’t leave you feeling groggy or have any of the other side effects associated with sleeping pills.
What is the Bone Broth Diet?
You may have heard about bone broth diets designed to help you lose weight and boost overall health. While you certainly don’t have to be quite this prescriptive to incorporate bone broth into your diet, some individuals enjoy having a plan laid out for them. The diet incorporates periods of intermittent fasting to boost metabolism, it’s a good idea to speak with your doctor before engaging in any fasts. People with blood sugar concerns or any similar health issues may need to avoid fasts. With that said, the benefits of bone broth described above can still be realized by simply drinking the mixture regularly alongside a healthy diet.
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