Adipose
Adipose-Derived Stem Cells: A Promising New Approach for Treating Secondary-Progressive Multiple Sclerosis
Multiple sclerosis (MS) is a chronic disease that affects the central nervous system, leading to a range of physical and cognitive impairments. There are different types of MS, with the most common being relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS). RRMS is primarily an inflammatory condition, while SPMS involves a progressive decline due to…
Administration of Adipose-Derived Mesenchymal Stem Cells via Intrathecal Injection for Traumatic Spinal Cord Injury
With over 290,000 people in the United States living with SCI and with roughly 17,000 new cases each year, spinal cord injury (SCI) is a serious condition that significantly impacts the lives of those affected. Considering the complexity associated with SCI, current treatments for SCI continue to focus mainly on managing symptoms and providing physical…
The Paracrine Activity and Differentiation Potential of Human Adipose-Derived Stem Cells Can Be Influenced by Age.
Stem cell therapy has been increasingly used as a therapeutic option in the treatment of numerous diseases, including many inflammatory and vascular diseases. The primary sources of stem cells are bone marrow (BM), dental tissue, adipose tissue, and umbilical cord blood; BM is considered the primary source of multipotent stem cells. While BM is an…
Phase 1 Clinical Trial Investigating the Use of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Traumatic Spinal Cord Injury
With more than 17,000 people in the US sustaining a spinal cord injury (SCI) each year and an estimated combined cost to healthcare and the workforce exceeding $40 billion, the condition has significant personal and socioeconomic implications. In addition, SCIs have limited pharmacological treatment options to support the regeneration of nerve damage. Considering the limited…
How Stem Cell Rejuvenation Leads to Healthier Aging
No one wants to grow old. That is apparent from the huge amounts of money people spend on anti-aging products and services each year. These products and services include everything from lotions to more invasive options like plastic surgery. However, healthier aging is possible without relying on invasive procedures. Stem cell rejuvenation, for example, offers…
Adipose Tissue-Derived Mesenchymal Stem Cells and Their Contribution to Tissue Regeneration
Mesenchymal stem cells (MSCs) isolated from a wide variety of tissues and organs have demonstrated immunomodulatory, anti-inflammatory, and regenerative properties that contribute to a host of regenerative and immunomodulatory activities, including tissue homeostasis and tissue repair. The most frequently studied and reported sources of MSCs are those collected from bone marrow and adipose tissue. In this…
Heterogeneity of Mesenchymal Stem Cells in Cartilage Regeneration
Articular cartilage, found on the surface of most musculoskeletal joints, distributes and transfers forces between bones and joints, provides a smooth surface for joint mobility, and plays an important role in human mobility. However, articular cartilage is also easily susceptible to damage, but difficult to repair itself on its own (primarily due to the fact…
Using Autologous Adipose-Derived Stem Cells and Platelet-Rich Plasma to Treat Symptomatic Knee Osteoarthritis
Osteoarthritis is the most common form of arthritis, affecting more than 900 million people around the world. Developing when the cartilage that protects your bones wears down, osteoarthritis (OA) most commonly affects the joints of the hand, hips, spine, and knees[1]. While current treatment for OA and related joint damage is focused primarily on managing…
Identifying the Therapeutic Significance of Mesenchymal Stem Cells
The immunosuppressive ability of mesenchymal stem cells (MSCs) coupled with their potential to serve important therapeutic roles in a wide range of immune disorders have resulted in a significant increase in the number of clinical studies examining the role of cellular therapy in a wide range of applications. Of particular interest is MSCs’ ability to…
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