CoQ10, Creatine, and Neuroprotection: What is the Link?

Coenzyme Q10 (CoQ10) is an antioxidant occurring naturally in the body. It is critical to the growth and maintenance of cells and is found to be lower in individuals with conditions such as Parkinson’s disease and Huntington’s disease. Research shows that taking CoQ10 supplements in combination with creatine may benefit individuals with these neurodegenerative conditions – but why?

CoQ10 & Creatine

Both CoQ10 and creatine are commonly found in meat and seafood. The body produces creatine naturally as well, in the kidneys, liver, and pancreas. It is an amino acid located in the brain and muscles, where it is used for energy. Together, both CoQ10 and creatine have neuroprotective effects. When taken in conjunction, they have been shown to improve motor performance and reduce DNA oxidative damage. They work by protecting against dopamine depletion and reducing lipid peroxidation, or the cellular damage caused by free radicals. CoQ10 and creatine have also been shown to reduce the volume of lesions found on the striatum, a part of the brain responsible for many aspects of cognition, including motor and action planning and decision making. In conditions like Parkinson’s disease, this area of the brain is compromised, resulting in symptoms such as tremors and slow movement. With Huntington’s disease, the degeneration of brain cells in this area causes progressive dementia.

How Should I Take CoQ10 & Creatine?

While CoQ10 and creatine can be ingested through food, they are found in minimal amounts in nutritional sources. Thus, eating more meat or seafood alone is unlikely to help you produce more of the antioxidant and amino acid. With that said, findings suggest that they can be taken as supplements as a form of combination therapy to treat neurodegenerative diseases. Moderate daily doses of CoQ10 (500-800 mg) in contrast with high doses (2,700 mg) in particular have been shown to yield mild to moderate improvements in symptoms like fatigue and muscle tone. Creatine has been shown to provide benefits for patients suffering from muscle-related pain. Before taking either CoQ10 or creatine, it is important for patients to discuss proper dosages and potential symptoms with their physicians for their ensured safety.