Men’s Wellness & Hormone Optimization
Medical Review: Dr. Gerald Mastaw, MD – Board-Certified Physician
Last Updated: October 2025
Understanding Men’s Health and Hormone Balance
Men’s health and vitality rely on a delicate balance of hormones, circulation, and cellular function.
As testosterone levels naturally decline, often starting in the 30s, many men notice changes in energy, mood, strength, metabolism, and sexual performance.
Common Signs of Hormonal Imbalance or Low Testosterone (Low T):
- Fatigue or decreased stamina
- Reduced libido or erectile difficulties
- Loss of muscle mass or strength
- Increased body fat, especially around the midsection
- Mood changes, anxiety, or brain fog
- Sleep disruption or poor recovery after exercise
Lifestyle, chronic stress, sleep patterns, and environmental toxins can all impact hormone production and metabolism.
Regenerative and hormone optimization therapies aim to restore balance naturally, improving both short-term function and long-term vitality.
Conventional Approaches to Men’s Health
Traditional medical care often focuses on treating symptoms or testosterone deficiency alone.
Common Options Include:
- Prescription testosterone replacement therapy (TRT): creams, injections, or pellets
- Medications for erectile dysfunction: sildenafil (Viagra), tadalafil (Cialis)
- Psychological counseling: for mood or stress-related contributors
- Lifestyle changes: nutrition, exercise, and sleep optimization
These treatments can be effective but may not fully address the root causes, such as vascular health, cellular energy, or hormone conversion imbalances (e.g., testosterone converting to estrogen).
Regenerative Medicine for Men’s Vitality
At Stemedix, regenerative medicine takes a restorative and preventive approach, helping men maintain peak health at every stage of life.
We focus on improving hormonal balance, cellular function, and overall vitality using evidence-supported biologic and metabolic therapies.
Therapies May Include:
- Bioidentical Hormone Replacement Therapy (BHRT): Restores natural testosterone levels to support energy, focus, libido, and metabolism.
- Umbilical Cord Tissue–Derived Stem Cells (UCT-MSCs): Studied for their ability to reduce inflammation, improve circulation, and promote tissue regeneration, particularly in vascular-related conditions.
- Platelet-Rich Plasma (PRP) Therapy: Used for sexual wellness (such as penile rejuvenation therapy) and to enhance blood flow and tissue response.
- Peptide Therapies and IV Infusions: Support muscle recovery, fat metabolism, sleep quality, and immune resilience.
Important:
Stem cell and PRP-based therapies for sexual or hormone optimization are investigational and not FDA-approved.
Research continues to show encouraging outcomes in male sexual wellness, metabolic health, and hormone support.
Recent Clinical Research in Regenerative Men’s Health
2024 – MSC Therapy for Erectile Function and Hormonal Support
Title: Umbilical Cord-Derived MSC Therapy in Men with Erectile Dysfunction and Low Testosterone: Phase I/II Trial
Journal: Frontiers in Endocrinology – Full Text
Summary:
Men receiving two intracavernous UC-MSC injections experienced increased testosterone levels, improved erection hardness scores, and enhanced penile blood flow by ultrasound.
No major adverse effects were reported, suggesting UC-MSC therapy may improve both sexual function and hormonal balance.
2023 – Platelet-Rich Plasma for Erectile Function
Title: Platelet-Rich Plasma Improves Erectile Function: A Randomized Placebo-Controlled Clinical Trial
Journal: Urology – PubMed
Summary:
Sixty men with mild-to-moderate erectile dysfunction received two PRP injections one month apart.
At 6 months, 69% reported meaningful improvement in erectile function scores, compared with 27% in the placebo group.
The study concluded PRP is a safe, minimally invasive option for men seeking natural improvement in erectile function.
2022 – Testosterone and Aging Meta-Analysis
Title: Benefits and Safety of Testosterone Therapy in Aging Men: Updated Meta-Analysis of Randomized Trials
Journal: Journal of Clinical Endocrinology & Metabolism – Full Text
Summary:
Across 35 studies, testosterone replacement led to improved lean muscle mass, bone density, libido, and mood without major safety concerns when monitored appropriately.
Researchers emphasized individualized therapy and consistent follow-up to optimize results and minimize risks.
Is Hormone or Regenerative Therapy Right for You?
You may be a good candidate if you:
- Have symptoms of low testosterone or hormonal imbalance
- Experience fatigue, low motivation, or cognitive decline
- Want to improve sexual wellness, energy, or muscle recovery
- Prefer a personalized, non-surgical approach that combines regenerative and metabolic optimization
At Stemedix, our goal is to restore function, vitality, and confidence naturally.
We begin with comprehensive lab testing, body composition analysis, and lifestyle review to tailor your treatment plan and track progress over time.
Medical Disclaimer
This page is for educational purposes only and does not constitute medical advice.
Stem cell, PRP, and hormone optimization therapies are not FDA-approved for anti-aging or sexual enhancement, and individual results may vary.
Always consult a licensed healthcare provider before beginning treatment.
References
- Khalifeh A. et al. Allogeneic Wharton’s Jelly-Derived MSC Therapy for Erectile Dysfunction. Front Endocrinol., 2024. PubMed
- Pachis K. et al. Platelet-Rich Plasma Improves Erectile Function: A Randomized Trial. Urology., 2023. PubMed
- Snyder P. et al. Testosterone Therapy in Aging Men: Updated Meta-Analysis. J Clin Endocrinol Metab., 2022. Full Text
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