2024 – Autologous P63⁺ Lung Progenitor Cells Trial
Title: Autologous Transplantation of P63⁺ Lung Progenitor Cells for COPD Therapy
Journal: Stem Cell Research & Therapy – PubMed Link
Summary:
A Phase I trial in China treated 17 COPD patients with their own lung stem/progenitor cells.
After 24 weeks, participants had improved lung function, better oxygen exchange, and greater exercise capacity (30-meter gain in 6-minute walk).
Two patients showed signs of tissue repair on CT scans. No serious side effects occurred, confirming good tolerability.
2022 – Systematic Review and Meta-Analysis of COPD Cell Therapies
Title: Stem Cell-Based Regenerative Therapy and Derived Products in COPD
Journal: Cells (MDPI) – Full Text
Summary:
Researchers pooled data from multiple COPD cell therapy trials. Treated patients walked ~50 meters farther on 6-minute tests and showed a trend toward better lung capacity (FEV₁).
While not a cure, the review found meaningful improvements in stamina and symptom control, supporting further study of MSC-based approaches.
2020 – Umbilical Cord MSC Pilot Study
Title: Allogeneic Umbilical Cord-Derived MSC Transplantation for Treating COPD: A Pilot Clinical Study
Journal: Stem Cell Research & Therapy – Full Text
Summary:
Twenty COPD patients received umbilical cord-derived MSC infusions. Treatment was safe and well tolerated, leading to less breathlessness, fewer flare-ups, and improved quality of life.
Researchers concluded that stem cell therapy may help reduce inflammation and stabilize symptoms in moderate to severe COPD.