Review of How Intranasal Delivery Helps Treat Neurodegenerative Disease

Review of How Intranasal Delivery Helps Treat Neurodegenerative Disease

A recent review published in BMC Neuroscience synthesizes research related to intranasal delivery and describes comprehensively how the method targets therapeutic agents to the central nervous system to treat neurodegenerative disease. Perhaps the most critical aspect of intranasal delivery is that it bypasses the blood-brain barrier, a barrier that limits the ability of other therapeutic approaches to successfully impact the brain and spinal cord.

According to the researchers, other advantages of intranasal delivery include its non-invasive nature and its rapid action. Intranasal delivery causes less pain and distress than other procedures, such as brain surgery, that are used to intervene in central nervous system activity when the blood-brain barrier cannot be penetrated with other available techniques. Further, intranasal delivery delivers drugs to the central nervous system in just minutes.

Given that intranasal administration is a relatively new approach, much research must be conducted to confirm which therapies can be effectively delivered to the central nervous system with this approach, as well as which diseases can be successfully treated with the method. Basic science research has provided promising data for the use of intranasal administration to reverse neurodegeneration and to rescue memory in Alzheimer’s disease.  Specific molecules have also been shown to protect the brain against stroke, as well as to stimulate the formation of new brain cells.

Research in Alzheimer’s patients and those with mild cognitive impairment has shown that intranasal insulin can improve memory and attention. Intranasal insulin has also been shown to enhance memory and mood in normal adults who do not suffer from clinical neurodegeneration. As more studies are performed on intranasal administration, it is likely that new uses of the technique will arise. Molecules, for instance, that have not yet been tested could become promising candidates for treating neurological disorders, and interventions for diseases that have not yet been adequately explored in terms of the relevance of intranasal administration may be developed.

Learn more about Alzheimer’s disease treatment here.

Reference

Hanson, LR, & Frey, WH. (2008). Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neuroscience, 9(3), 55-59.

Bone Marrow Derived Stem Cells Show Promise for Treating Osteoarthritis

Bone Marrow Derived Stem Cells Show Promise for Treating Osteoarthritis

In a review published in Stem Cell Research & Therapy, Gupta et al. describe the latest advances in the use of bone marrow derived stem cells to treat osteoarthritis. These cells are promising because of their ability to treat the degeneration of cartilage that occurs in the disease. When connective tissue degenerates, natural regeneration is highly limited because there is not a strong presence of vasculature within that tissue. Thus, interventions to deal with the effects of osteoarthritis are needed.

Historically, non-stem cell treatments have been used in attempts to treat cartilage degeneration. Physical therapy, pharmaceuticals, and surgical interventions have all been largely employed. For mild cases of osteoarthritis, combinations of physical therapy and pharmaceuticals have been used to manage pain and minimize inflammation. Unfortunately, because the disease is progressive, this type of approach is only effective in the short-term.

Eventually, steroids or hyaluronic acid are generally used to treat osteoarthritis. The impact of these more aggressive treatments, however, is debated and does not appear to be consistent across patient populations. Once osteoarthritis reaches the advanced stage, joint replacement is the only option for relief.

The use of cell-based therapies to treat osteoarthritis is not a new idea. Cultured autologous chondrocytes have been shown to successfully treat cartilage degeneration for over 15 years. The downsides to this approach are that it is invasive, the positive effects are likely temporary, and there has not been sufficient research conducted to fully understand how well the technique works and how to optimize it.

Bone marrow derived stem cells have the potential to carry the same success rate as the cell-based therapies that have long been used to treat osteoarthritis while also overcoming the limitations of those therapies. There are several advantages of the application of bone marrow derived stem cells in the treatment of cartilage degeneration.

First, these particular cells can be easily isolated. Second, they can significantly expand in culture before being used therapeutically. Third, they have modulatory properties that enable them to reduce inflammation, which is a critical factor in cartilage degeneration. Finally, they secrete factors that have the potential to both prevent further degeneration and facilitate regeneration.

Given the number of reasons that bone derived stem cells should theoretically improve upon current methods for treating the cartilage degeneration that occurs in osteoarthritis, more research will likely be conducted to decipher whether these cells do indeed provide benefits that other treatment options do not. In the case that these cells continue to appear promising for osteoarthritis treatment, research will likely also aim at determining the best protocols for using these cells to ensure the best outcomes for osteoarthritis patients.

 

To find out more about the new alternative way to manage the symptoms of Osteoarthritis, click here.

 

Reference:

Gupta, PK, Das, AK, Chullikana, A, & Majumdar, A. (2012). Mesenchymal stem cells for cartilage repair in osteoarthritis. Stem Cell Research & Therapy, 3, 25-34.

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